Adequan Equine Injectable for Horses 100mg/mL, 5-mL Single Dose Vial

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Adequan is an FDA-approved injectable medication prescribed for the treatment of equine non-infectious degenerative joint disease (DJD), specifically in the carpal and hock joints (the equivalent of the ankle bone in humans). DJD can cause joint pain and inflammation, which can often lead to horse lameness. Lameness occurs when the horse overcompensates for the affected area, resulting in abnormal movements. Adequan can help reduce the damaging process of DJD, help reverse the loss of cartilage and encourage healthy joint function and associated lameness.


Adequan (polysulfated glycosaminoglycan) is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.

Possible Side Effects

There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.

Drug & Food Interactions

Talk to your veterinarian about any other drugs your horse is taking before starting this medication.


Studies have not been conducted to establish safety in breeding horses. Do not use in animals intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  1. Prescribing Information

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  • Item Number
  • For Use With
  • Dosage Measure
    Use according to your veterinarian's instructions.
  • Common Brand Name(s)
  • Generic Name
    Polysulfated Glycosaminoglycan
  • Health Condition
    Joint Pain/Arthritis, Muscle Lameness
  • Drug Type

Polysulfated Glycosaminoglycan

Recommended Dosage

Administer 1 intramuscular injection (500 mg) every 4 days for 7 treatments. Consult with your veterinarian regarding any questions on dosing.

Storage Instructions

Store at controlled room temperatures between 68° - 77°F; excursions permitted to 59° - 86°F.


What is the FDA approved dosing regimen for Adequan?

Confirmed by findings from a Dose Titration Study, the recommended dosage1 of Adequan is 500 mg every 4 days for 28 days intramuscularly (for a total of 7 injections).

Why is Adequan administered every 4 days?

Concentrations of Adequan at or near therapeutic levels were detected in the cartilage of all eight horses 96 hours post-injection.

Are there “prophylactic” or “maintenance” dosing regimens for Adequan?

No, upon an initial diagnosis of Degenerative Joint Disease, treatment recommendations are to initiate 500 mg every 4 days for 28 days intramuscularly. The series may be repeated as needed upon recurrence of the clinical signs of Degenerative Joint Disease and associated lameness of the carpal and hock joints.

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  • 5 out of 5 stars

    Approved by my vet to use on my senior lab/border collie mix

    By on

    I use this on my 14 year old lab/border collie mix. She has pretty severe arthritis, I'm only three shots in to the initial dose stacking phase and I'm positive she's already getting a little relief. It doesn't take her quite as long to get up from laying down and she seems a little more hyper than usual. I can't wait to see how she feels when she gets a few more doses in her over the next few couple weeks.

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  • 5 out of 5 stars

    100% Satisfied

    By on

    My purchase of Adequan from Chewy went smoothly, and arrived quickly after the veterinarian signed the prescription. Adequan worked as it should for my horse, and now he's back to his old self again and is feeling great! It was terribly difficult to find this product anywhere else, but thanks to Chewy, I was able to get my horse the joint support he needs. Thanks Chewy!

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  • 5 out of 5 stars

    Chewy made it easy

    By on

    My DVM prescribed Adequan IM for my dog for arthritis. This is marketed for horses but appeared to be exactly the same as the canine-labeled. I let Chewy contact my vet and they approved it so I'm now giving the injections. And the meds arrived so quickly it was amazing. I love Chewy's fast, reliable service. Also, their phone support is amazing when I've made a boo-boo order. As for the Adequan, two weeks into it the jury's out...

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  • 5 out of 5 stars

    Highly recommended

    By on

    Since my 11 year Akita has been taking Adequan we've seen a huge difference after the 3 shot she starting feeling so much better.

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