Advantage II Flea Spot Treatment for Cats, over 9 lbs

By Advantage II
Rated 4.3503 out of 5 stars
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply) slide 1 of 12
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Advantage II Flea Spot Treatment for Cats, over 9 lbs, 6 Doses (6-mos. supply) slide 1 of 12

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About This Item

  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing over 9 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 2, 4 or 6 treatments.
Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Top IngredientsActive Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients: Spinetoram 11.2% Other Ingredients: 88.8%Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.Active Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.
Small Pet TypeN/AN/AN/AFerretN/A

Questions & Answers

33 Customer Questions

How many treatments in box?
Answer by ChewyJun 03, 2021
This product is available in single doses, 2, 4 or 6 dose treatment boxes.

Do the fleas haveto bite my cat to die or do they die on contact
Answer by ChewyDec 06, 2021
This treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required.

Since the product is applied to your cats neck, what about the fleas on the cats belly will they move to the neck?
Answer by ChewySep 19, 2017
The active ingredients of Advantage II work to attack the fleas, no matter where they're located on your cat.

Do I have to treat for fleas all year, I live in TN?
Answer by ChewyAug 26, 2017
One convenient application of Advantage II cat flea treatment keeps working for 1 month. If your cat still has fleas after the 1 month, we'd recommend treatment for another month until the fleas are gone.

ReviewsWrite a Review

Rated 4.3503 out of 5 stars
2281 Reviews
Would recommend to a friend

2281 Customer Reviews

Rated 1 out of 5 stars
By JoyM on Apr 9, 2022

Doesn't work

used advantage before and wasn't happy with it. But was told it was better now. Wrong. My 3 INDOOR cats show fleas within 2 weeks of use. I have shampooed and deep cleaned everything and don't believe I have any eggs hiding. I have an indoor outdoor dog that is on Vectra and she doesn't have fleas. (vet checked). I will switch to Vectra for my cats too.

Rated 1 out of 5 stars
By Petey on May 11, 2022

Does not kill fleas

I have bought this Advantage II for the last time. Have used it several times and it just does not work. It is a total waste of money. Very expensive for the small drop of treatment in a tube and then for it not to work.

Rated 2 out of 5 stars
By Shelldear on May 11, 2022

Still have fleas

I have put this on my cat for 2 doses and I still have fleas in the house. They are not as bad as they were a few weeks ago but I have also had to get a flea spray for the carpets to try to get them under control. Ugh!

Rated 5 out of 5 stars
By Maxie on Apr 27, 2022

Flea Treatment for Adult Cats

I have been using Advantage II on my two cats for 15 years. I am happy to say there has never been a flea found in my house. My cats are thrilled I know to not have to scratch all the time. I will use this product as long as I own cats.

Rated 3 out of 5 stars
By MsTeenaT on Apr 14, 2022

Not long lasting

This has worked very well from the time of application until about two weeks. It says it lasts for up to a month which is misleading if you plan on purchasing once a month. It actually lasts for up to two weeks. Very disappointed and will be trying something else that lasts longer.

Rated 5 out of 5 stars
By Saeki on Mar 29, 2022

it worked for me

I have a senior cat and she has always had sensitive skin. I have used other top of the line flea drops but in the end would irritate her skin. I decided to try this one mainly because it was just for fleas, the other drops would kill ticks and lice etc and Maybe the chemicals where just to harsh. Well she is a inside cat, and I don’t live in tick country so I just wanted flea control. Well I applied it, put a white cloth down in her bed, the next day there was a lot of dead fleas and she’s not having a bad reaction. Win win for me and her.

Rated 5 out of 5 stars
By Runt on Apr 27, 2022

Wow, amazing!

I was buying a cheaper flea med that sent my male cat crazy for at least 45 minutes. I switched to Advantage and he hardly reacted at all. Yet it is working to rid both of my cats from fleas - yay!!

Rated 3 out of 5 stars
By yumyum on Apr 26, 2022

kk outdoor cat

Easy to apply. Found that didn't absorb quickly. Sat on fur for several days even though applied to skin. Found engorged tick on neck several week after application.

Rated 5 out of 5 stars
By LynnZ on Apr 1, 2022

Great product

I’ve been using Advantage II since it first was introduced & recommended by our vet. The fur kids don’t like having it applied and will be avoiding me for a few days after, but we all like the results - ie NO fleas.

Rated 5 out of 5 stars
By Georgie on Apr 12, 2022

Flea control without a vet visit

Advantage still works for us. Saved us an expensive trip to the vet for a prescription for the latest flea-resistant formulation. Chewy is efficient in quick delivery as usual