ADVANTAGE II Flea Spot Treatment for Cats, 5-9 lbs, & Ferrets, 12 Doses (12-mos. supply) -

Advantage II Flea Spot Treatment for Cats, 5-9 lbs, & Ferrets

By Advantage II
Rated 4.2459 out of 5 stars
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About This Item


  • Veterinarian-recommended treatment kills fleas cats 8 weeks or older and weighing 5-9 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 2, 4 or 6 treatments.

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Play Video: Learn More About Advantage II From Our Team of Experts
Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Cat

Experience the Benefits of Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended topical formula works to kill adult fleas as well as flea larvae and eggs, so your cat can focus on you. It only needs to be applied once a month and is for cats and kittens 8 weeks of age or older.

Why Choose Advantage II?

Advantage II is waterproof, fragrance-free and kills fleas directly through contact. That means pesky fleas dont have to bite to perish. It kills fleas within 12 hours of the first application and can protect against further infestation for up to a month. Best of all, with Advantage II, you can stop multiple flea life stages, to effectively break the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas. The first active ingredient kills adult fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Cat?

Whether your cat is a winter sunspot-stealer or a summer backyard explorer, an sunseeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your cat, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Cats of All Sizes


2-5 pounds


5-9 pounds


Over 9 pounds

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with effective flea prevention that lasts all month.
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Questions & Answers

33 Customer Questions

Since the fleas do not have to bite my cat to be killed do they have to crawl over the specific application site to be killed?
Answer by ChewySep 07, 2017
This product doesn't require fleas to bite for it to take effect but it must come into contact with the pest.

Is this safe for Nursing cats? If so will it also protect the newborn kittens from fleas?
Answer by ChewyJul 26, 2017
As with any product, it's best to consult your veterinarian before using this product on pregnant or nursing cats.

how many cc are in one application tube?
Answer by ChewyAug 04, 2018
Each application tube contains 0.4 cc.

Cat is about 9 lbs, which size?
Answer by ChewyMay 27, 2020
The Advantage II for Kittens is for use only on cats 8 weeks and older and weighing 2-5 lbs. The Advantage II for Small Cats is for use on cats weighing 5-9 lbs. The Advantage II for Large Cats is for use on cats weighing over 9 lbs. We recommend weighing your cat to determine which flea treatment is needed.

ReviewsWrite a Review

Rated 4.2459 out of 5 stars
1090 Reviews
Would recommend to a friend

1090 Customer Reviews

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Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By buckroth on Feb 19, 2023

Effective and Well Tolersted

This is my go-to product when the fleas threaten to take over. The house we rent previously had cats inside and out. The fleas initially were overwhelming our indoor cats. We finally had to dose our cats 7 days apart before settling into the monthly routine. All our cats barely register when we apply their monthly dose. I know that some cats will react strongly and even get sick, but in the 2 decsdes we've been rehoming stray and dumped cats, none of them have ever gotten sick from the application of this product. Some of our cats were dealong with other issues but still tolerated this product well. I can recommend it's worth a try if you're willing to stick to 3-4 monthly application schedule to break the flea life cycle.

Rated 1 out of 5 stars
By Shiloh on Mar 3, 2023

Did Not Work !

We do not have fleas anywhere else except on our cat and 10 days after treatment I am still finding full grown fleas actively crawling on and biting her. Also it gave her diarrhea which was not fun for anyone. I have used other products that were immediately effective. Someone thought I was just being cheap but no it actually worked best.

Rated 5 out of 5 stars
By Emma on Feb 5, 2023

Easy flea treatment

Please flea treat indoor animals! Especially if you live in an apartment complex that allows pets. better safe than sorry. We have lots of dogs walking around outside and some how a flea got on our indoor cat. Usually it is a fight to get Monkey to get her flea treatment. This one was easy to use. No bad smells. No hair loss. Dries quickly. Works very quickly too!

Rated 5 out of 5 stars
By augie on Feb 16, 2023

for the outdoor ferals

besides my own indoor cats, i'm taking care of two outdoor ferals. they let me pet them and i'm able to put the drops on without them even realizing it. they go into the woods where the deer are so i'm trying my best to protect them as much as possible from fleas and ticks.

Rated 1 out of 5 stars
By kitten on Dec 28, 2022

something changed

I saw somebody else mention a possible formula change, and I wanted to chime in and say this is also what I thought. I have been using this for about a year on my cat with no issues. Recently, I opened a new box and gave it to my cat and she had a bad reaction (drooling, lethargy, drowsiness, overall not acting herself) almost immediately after applying. I ended up having to bathe her with Dawn to get all the product off. I did not do much research on the topic, but even the vet could not see why this would happen suddenly when I have been using the same product for a year - the only explanation they could offer was a formula change. Just wanted to throw that out there as a caution to keep an eye on your cats after giving them this even if you've been using it for a while!

Rated 5 out of 5 stars
By Megan on Jan 24, 2023

Great Product!

I started using this on my cat almost a year ago, she had a bad flea allergy, scabs under her chin, on her ears, and various parts of her body from scratching so much. She was losing hair on her back. Started using this and now she has no scabs for the first time in her life, and her hair has grown back thicker than ever. This is a wonderful product I highly recommend!

Rated 3 out of 5 stars
By CAROL on Jan 3, 2023


Years ago, I used Advantage on all my dogs and cats and it was really great. I believe it was made by Bayer. I have put this on my 6 mos old kittens and within one week, they are scratching and digging again. They came with fleas and I am having a hard time getting rid of them. Never had this problem with all the dogs and cats I have had. Was going to contact your pharmacy to see what else I could use but when I tried that before, there were so many questions, etc. Ughh!

Rated 5 out of 5 stars
By Cath on Mar 11, 2023

Advantage ll flea, tick, and larvae drops

You definitely need meds that include flea egg and larvae We had Super Fleas lately The sudden weather changes have not helped Thanks Chewy

Rated 5 out of 5 stars
By JimU on Mar 3, 2023

Easy To Use

This was the first time we used a flea medication on our cat since we adopted her a year and a half ago. It went on easy, and she is doing fine.

Rated 5 out of 5 stars
By Chris on Mar 14, 2023

Good Product

Good product that helps my cat to be away from bugs. I can finally take my cat out as she always wanted to do so.