Advantage II Flea Treatment for Dogs, 21-55 lbs

By Advantage II
Rated 4.2236 out of 5 stars

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$47.98Chewy Price
$45.58Autoship Price
(Save an extra 5%)

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FREE 1-3 day delivery

Frequently Bought Together

Vet's Best Indoor Flea & Tick Home Spray Refill for Dogs, 32-oz bottle
Rated 3.8568 out of 5 stars
$15.40Chewy Price
Total Price: $122.87

About This Item


  • Flea protection for dogs weighing 21 to 55 pounds, at least 7 weeks old.
  • Easy-to-apply monthly topical treatment.
  • Delivers total flea protection and kills adult fleas, flea larvae and flea eggs through contact.
  • Starts killing fleas the same day and keeps working for 30 days.
  • Fragrance-free formula is waterproof after 24 hours of application.

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Learn More About Advantage II From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About Advantage II Dog

About Advantage II Dog

Help stop the misery of biting fleas with Advantage II. This vet-recommended, monthly topical formula works to kill adult fleas as well as flea larvae, eggs and lice, so your pup is ready for fun. Plus, it's for dogs and puppies 7 weeks of age or older. Help your pal get the effective protection he needs by experiencing Advantage II.

Why Choose Advantage II?

Advantage II is fragrance-free, odorless, waterproof after 24 hours of application and kills fleas directly through contact. That means pesky fleas don't have to bite to perish. With just one application, you can prevent further flea infestations for up to 4 weeks and can even help prevent, control and treat lice infestations. With Advantage II, you can stop multiple flea life stages, effectively breaking the flea life cycle.

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas in their tracks. The first active ingredient kills fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right Choice for Your Dog?

Whether your dog is a winter snow hound or a summer backyard explorer, an indoor sun seeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your dog, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Every Size Dog


3-10 pounds


11-20 pounds


21-55 pounds


55 pounds and over

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with protection they need.
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Top IngredientsActive Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients : Imidacloprid 9.10% , Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%.Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%...Active Ingredients: Imidacloprid 8.80%, Permethrin 44.00%, Pyriproxyfen 0.44%....
LifestagePuppy, Adult, SeniorPuppy, Adult, SeniorAdultPuppy, Adult, SeniorAdult
Breed SizeSmall Breeds, Medium BreedsExtra Small BreedsLarge Breeds, Giant BreedsSmall Breeds, Medium BreedsLarge Breeds, Giant Breeds

Questions & Answers

9 Customer Questions

Is it possible to apply half the tube, then the other half at a later day, say a week after?
Answer by ChewyFeb 18, 2023
For best results, it is recommended that you apply the entire contents of the tube evenly on the top of the back from the shoulder to the base of the tail.

How long will this product protect my dogs if they are swimmers???
Answer by ChewyApr 03, 2018
This product is waterproof and swimming will not have any effect on it.

What are the inactive ingredients?
Answer by ChewyJun 08, 2023
This treatment has 94% based alcohol as an inactive ingredient.

will advantage II kill or repel mosquitoes?
Answer by ChewySep 08, 2022
This treatment does not repel mosquitoes.

ReviewsWrite a Review

Rated 4.2236 out of 5 stars
237 Ratings
Would recommend to a friend

237 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By MrMega on Jul 7, 2023

Only one that works for us

This is the only one that works for us (we live in the country). Everything else is like a squirt of water on our dog. Super fast shipping from Chewy is always a big plus, too!

Rated 1 out of 5 stars
By Gina on Aug 26, 2023

This product did not work on my dog. He is still scratching and itchy

Rated 5 out of 5 stars
By Popabear on Apr 20, 2023

Wrong product

Thought I ordered Flea and Tick , but received flea only. Will what I have also kill ticks ? If not, can I return what You I have and get flea and tick ? If so you have my credit card. Ship what I need and I will send back the other in the box you send. Probably need a RA. Thank you.

Rated 5 out of 5 stars
By Cloie on Apr 5, 2023

Cheaper than in-store prices!

I've been having such a hard time finding this product on shelves in stores near me, and when they have it the right dosage for my dog costs almost $60. I've used this brand on my dog since she was a puppy (after she was old enough to use this product) and it has worked for us so well, and the application is super easy as well!

Rated 4 out of 5 stars
By Cheryl on Apr 15, 2023

Flea meds for dog

I needed this quickly. I haven't done a price comparison yet, but I got it fast. Thanks Chewy

Rated 5 out of 5 stars
By Julieko on Apr 20, 2023

Good Product

My vet recommended this product over the other one I had ordered. It works better!

Rated 5 out of 5 stars
By Anna on Jun 15, 2023

Great Service

Got it quick and my dogs are Happy Now..:)

Rated 5 out of 5 stars
By Becky on Jun 23, 2023

The collars were great. Thank u.

Rated 1 out of 5 stars