Advantage II Flea Treatment for Large Dogs 21-55 lbs

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6 treatments
  • 4 treatments
  • 6 treatments
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Help protect your furry friend from parasitic pests and the potentially harmful diseases they can transmit with Advantage II Flea Treatment for Large Dogs. This highly-effective, veterinarian-recommended treatment is specifically formulated to kill all life stages of fleas on contact with no painful biting required. With three-way protection that kills the eggs, larvae and adults, it breaks the flea life-cycle to help prevent re-infestation of both your house and hound. The waterproof formula for dogs 7 weeks or older and weighing between 21 and 55 pounds continues working for up to four weeks, even after bathing or swimming.

Key Benefits
  • Veterinarian-recommended treatment kills all life stages of fleas on puppies and dogs 7 weeks or older and weighing 21-55 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing or swimming.
  • Convenient, monthly topical application contains imidacloprid and pyriproxyfen; available in packs of 4 or 6 treatments.

For use only on dogs and puppies 7 weeks and older and weighing 21 - 55 lbs. DO NOT USE ON CATS. Keep out of reach of children. If your dog is on medication, consult your veterinarian before using this or any other product. Do not get this product in your dog's eyes or allow your dog to ingest this product.

New look, same great formula! This product has recently undergone a packaging change. Customers may receive old packaging during this transition.

Active Ingredients

  • Imidacloprid 9.10%
  • Pyriproxyfen 0.46%

See all items by Advantage II

  • Item Number
  • Brand

    Advantage II

  • Brand


  • Breed Size

    Small Breeds, Medium Breeds

  • Lifestage

    Adult, Puppy, Senior

  • Made in



How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet‘s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dogs should be standing for easy application. Apply the entire contents of the tube evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog‘s eyes or allow your dog to ingest this product.
  • Discard empty tube.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is attained, return to a monthly retreatment schedule.
Dog Weight Advantage II
3 - 10 lbs Small Dog
11 - 20 lbs Medium Dog
21 - 55 lbs Large Dog
Over 55 lbs Extra Large Dog

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage II.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II adds larvicidal and ovicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


About Advantage II Dog

Experience the Benefits of Advantage II

Experience the Benefits of
Advantage II

Help stop the misery of biting fleas with Advantage II. This vet-recommended, monthly topical formula works to kill adult fleas as well as flea larvae, eggs and lice, so your pup is ready for fun. Plus, it's for dogs and puppies 7 weeks of age or older. Help your pal get the effective protection he needs by experiencing Advantage II.

Why Choose Advantage II?

Advantage II is fragrance-free, odorless, waterproof after 24 hours of application and kills fleas directly through contact. That means pesky fleas don't have to bite to perish. With just one application, you can prevent further flea infestations for up to 4 weeks and can even help prevent, control and treat lice infestations. With Advantage II, you can stop multiple flea life stages, effectively breaking the flea life cycle.

Help Break the Flea Life Cycle

Help Break the Flea Life Cycle

Immature fleas in a pet's environment consist of around 95% of an infestation and can be nearly invisible to the naked eye. That's why Advantage II has two active ingredients that work to stop fleas in their tracks. The first active ingredient kills fleas by targeting their nervous system, while the second works as an insect growth regulator that kills flea eggs and larvae.

Is Advantage II the Right
Choice for Your Dog?

Whether your dog is a winter snow hound or a summer backyard explorer, an indoor sun seeker or an outdoor enthusiast, choose Advantage II to help keep fleas from interrupting his favorite activities year-round. If you want to return the love to your dog, take care of him with flea prevention that works to kill the fleas you see and the ones you don't.

Advantage II for Every Size Dog

Advantage II Flea Treatment for Small Dogs

Advantage II Flea
Treatment for Small Dogs

3-10 pounds

Advantage II Flea Treatment for Medium Dogs

Advantage II Flea
Treatment for Medium Dogs

11-20 pounds

Advantage II Flea Treatment for Large Dogs

Advantage II Flea
Treatment for Large Dogs

21-55 pounds

Advantage II Flea Treatment for Large Cats

Advantage II Flea Treatment
for Extra Large Dogs

55 pounds and over

About Advantage II

Advantage II is manufactured by Bayer, a leading name in the healthcare industry for over 150 years. Advantage II is a veterinarian-recommended monthly flea treatment for your pet that kills fleas through contact. Targeting fleas, flea larvae and flea eggs, Advantage II is an effective treatment designed to provide dogs and cats with protection they need.

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About Advantage II
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