Advantage Multi Topical Solution for Cats, 9.1-18 lbs, 6 treatments

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Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Advantage Multi for Cats is a broad-spectrum topical solution prescribed by veterinarians to provide pet parents with a convenient monthly application to help alleviate symptoms caused by pesky parasites. This easy-to-use solution works to kill adult fleas, treat and control ear mites, roundworm and hookworms—it may also help to prevent heartworm disease in some cats.


Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria Immitis in cats and ferrets 2 pounds or over. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. 

Possible Side Effects

Contact your veterinarian if your pet experiences pruritus/scratching, scabbing, redness, wounds and inflammation at the treatment site; lethargy; and chemical odor. 

Drug & Food Interactions

Talk to your veterinarian about any other drugs your dog is taking before starting this medication.


Do not dispense dose applicator tubes without complete safety and administration information. Avoid oral ingestion. Cats may experience hypersalivation, tremors, vomiting and decreased appetite if Advantage Multi for Cats is inadvertently administered orally or through grooming/licking of the application site. The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats. The effectiveness of Advantage Multi for Cats against heartworm infections (D. immitis) after bathing has not been evaluated in cats. Use of this product in geriatric pets with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.

  1. Prescribing Information

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  • Item Number
  • Common Brand Name(s)
    Advantage Multi
  • Dosage Measure
    30 days
  • Generic Name
    Imidacloprid, Moxidectin
  • For Use With
  • Brand
  • Breed Size
    Medium Breeds
  • Product Form
  • Strength
    80 mg Imidacloprid and 8 mg Moxidectin
  • Health Condition
    Heartworms, Fleas, Roundworms, Hookworms, Ear Mites
  • Drug Type

Active ingredients: 80 mg Imidacloprid (10%), 8 mg Moxidectin (1%)

Recommended Dosage

The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration.

Storage Instructions

Store at room temperature between 39° - 77°F.


How often can I use Advantage Multi for Cats?

Use monthly (every 30 days), year-round, to kill fleas; treat flea infestations; treat and control ear mites, hookworms and roundworms; and prevent heartworm disease.

When should I put Advantage Multi for Cats on my cat?

You should apply Advantage Multi for Cats monthly (every 30 days), all year-round.

How do I apply Advantage Multi for Cats?

Do not apply to irritated skin.

  • Remove one dose applicator tube from the package.
  • While holding the tube in an upright position, remove the cap from the tube.
  • Turn the cap over and push the other end of the cap onto the tip of the tube.
  • Twist the cap to break the seal and then remove cap from the tube.
  • Part the hair on the back of the cat's neck at the base of the head, until the skin is visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift the tube away from skin before releasing pressure on the tube.

Do not get this product in the cat's mouth or eyes or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming.

How old does my cat have to be to use Advantage Multi for Cats?

Advantage Multi for Cats can be used on cats at least 9 weeks old, weighing at least 2 pounds. The small cat size (5.1-9 lbs.) can be used for ferrets that weigh at least 2 pounds.

Does Advantage Multi for Cats expire?

Advantage Multi for Cats does have an expiration date that can be found on the bottom edge of the package. Advantage Multi for Cats should not be used past its expiration date.

Does Advantage Multi for Cats kill ticks?

No. Advantage Multi for Cats helps provide broad-spectrum protection against fleas, ear mites, roundworms, hookworms and heartworms. If you are concerned about ticks, Bayer has effective products that treat and prevent tick infestations.

How does Advantage Multi for Cats work to kill fleas?

Advantage Multi for Cats is applied to the pet's skin. The active ingredient spreads over your cat's body to kill fleas through contact so they do not have to bite your cat to die.

What if I miss an Advantage Multi for Cats heartworm treatment?

Life happens. If you forget or miss a dose, simply treat your cat immediately. Advantage Multi for Cats is heartworm prevention that forgives if you forget. It kills newly acquired heartworm larvae (baby worms) throughout the month to prevent further infection. After a single dose, if you forget and go more than 30 days in between treatments, just treat immediately and resume your monthly schedule.

38 Reviews 38 Reviews 4.8 out of 5 Stars

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97% of reviewersrecommend this product

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38 Reviews

Showing 1-10 of 38 Reviews

  • 5 out of 5 stars

    Perfect flea protection

    By on

    Since I’m a crazy cat lady and have 3 rescues and now 2 orphans I’m bottle feeding and will probably keep the last thing I need is fleas. This product has always come thru for me and the kitteos. No fleas here so I’m happy and so are they.

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  • 5 out of 5 stars

    Love the savings!

    By on

    We have 5 cats in our household so flea and parasite prevention gets quite expensive. Buying Advantage Multi from Chewy is saving us a considerable amount.

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  • 5 out of 5 stars

    Tropical solution for my cat

    By on

    I love this advantage Multi for my cat Max I have been giving him this for probably 6 or 7 years now. It works great for him and I don’t have to worry about fleas, ticks, and etc.

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  • 5 out of 5 stars

    Advantage multi

    By on

    This product works really well on my cat. Haven't seen a flea since I've been using it which has been about three years. Ticks have been rare also. Her exams for internal parasites has always been negative.

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  • 5 out of 5 stars

    Great product.

    By on

    This product is an effective improvement over other versions and really helps to provide protection for my pets, especially since we live in the south where, because of the weather, we have an extended "flea period."

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  • 5 out of 5 stars

    Advantage Multi is the Best!

    By on

    I've used Advantage Multi for my 8 year old cat year after year with positive results. It protects him all summer long from the five pest listed~ most importantly to me "Heartworms". It's easy to order prescription medication from Chewy Pharmacy just by supplying your vet's contact information and Chewy does ALL the rest!

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  • 5 out of 5 stars

    Amazing product!

    By on

    I love advantage multi and have been using it on my cat for years. He used to get ear mites so frequently and I didn't know what to do. My vet prescribed advantage multi and we have never looked back. Cheney's customer service just made me love the product more!! I highly recommend.

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  • 5 out of 5 stars

    Best ever product

    By on

    This product not only protects against fleas, but many other bad things that attack cats. My cat is bothered by ear mites and he has not had an attack since I have been using the Advantage Multi. Great product!!

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  • 5 out of 5 stars

    Filling cats perscription

    By on

    Chewy called my vet and got the script and a few days later we were all set

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  • 5 out of 5 stars

    No itching from fleas

    By on

    Product does what it claims. Easy to use. My cat enjoys the freedom of being able to go outside. I like knowing she will not bring in fleas or ticks.

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