API General Cure Freshwater & Saltwater Aquarium Parasitic Fish Disease Treatment

Rated 3.8519 out of 5 stars


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$127.95Chewy Price
$229.98Chewy Price
$121.55Autoship Price
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Total Price: $391.93

About This Item


  • Formulated to help treat parasitic diseases.
  • Can help treat velvet, fish lice, hole-in-the-head disease, plus gill and skin flukes.
  • Works quickly to help heal your underwater buddies.
  • Available in 10 individual powdered packets or a 30-oz. bottle.
  • Will not color your aquarium water.

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Fish TypeBetta, Bottom Feeder, Cichlid...Marine Fish, Tropical FreshwaterMarine Fish, Tropical Freshwater
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Questions & Answers

30 Customer Questions

Will this kill internal parisites
Answer by ChewyJan 18, 2018
The General Cure treats for internal parasites.

Will this harm the snail in my tank? She’s a yellow mystery snail.
Answer by ChewyMay 05, 2018
This product will not harm snails.

Does this product adversely affect biological filtration?
Answer by ChewyJul 26, 2018
This treatment doesn't kill the biological filtration, however you do have to remove carbon or zeolite if you have it in your filter because it will absorb the medication.

I have Koi pond - is this product used as a preventative product for outside use,
Answer by ChewyJun 28, 2022
The API General Cure product will remove parasites from fish regardless of whether they are kept indoors or outdoors. Outdoor fish may need to be moved to a temporary quarantine tank for treatment, to assure proper dosing, if the exact water volume is not known or is too large for treatment. This product should not be used in unlined ponds and is not for fish intended for human consumption. You are able to re-treat with this product if needed, such as when new fish are introduced that may be harboring new parasites. For ponds that are too large or for fish that are un-catchable: we recommend use of API Pond Salt to reduce disease in ponds.

ReviewsWrite a Review

Rated 3.8519 out of 5 stars
27 Ratings
Would recommend to a friend

27 Customer Reviews

Rated 5 out of 5 stars
By Char on May 16, 2023

Not toxic, but unsure if effective

I purchased this product to treat my female betta, who suddenly presented with a dramatically swollen abdomen on the right side of her body. She became ill after I introduced ghost shrimp to the tank and 3 rounds of kanamycin didn’t help at all, so I decided to try this in case she’d picked up parasites. The packets of General Cure are easy to open and very conveniently dosed where 1 packet = 10 gallons. I did a 3-dose treatment course and while she still looks weirdly swollen she didn’t react badly to the medication at all. She’s in a filtered, planted, 5 gallon tank- just as background info. I obviously removed her carbon filter for the treatment and the General Cure didn’t turn my water a strange color, which was nice. My plants and snails don’t seem negatively affected, either. I can’t say how effective this product is, since she still looks swollen, but she might honestly just have something else wrong with her so I can’t fault the product for that. Overall this product is easy to use and caused no obvious toxicity, so I would recommend giving it a try.

Rated 3 out of 5 stars
By ryn2011 on Jul 14, 2022

Not Sure Really

This is supposed to help treat my fish and was recommended by another aquarist friend. Unfortunately, it did not help or hurt. I don't really have more input. It does cloud your water and you have to use a lot for larger tanks

Rated 5 out of 5 stars
By Becky on Feb 8, 2022

Seems to do the job for worming the fish

I use this if I suspect the goldfish are having issues with internal parasites. The symptoms have improved after treatment, so it seems to be effective.

Rated 5 out of 5 stars
By joanna on Mar 29, 2022

very good recommend for friends and family

good product and fest delivery i love chewy store to shop

Rated 5 out of 5 stars
By Jennifer on Aug 7, 2021

General cure

We searched everywhere drove hours to try and find General cure during it's shortage. I am very greatful it returned when it did (sad not sooner). With two doses I was able to save a krib suffering from Popeye. He barley has any Popeye left we will repeat a third dose to clear it up the rest of the way. He was one of the worse cases I had experienced and we didn't expect him to pull thru, thankfully on day 4 general cure got here. I also have a Angelfish with HITH I did treatment once of two days already and my water change... Definitely when we took pictures and compare them very big noticeable difference. Due to sensitivity, I was giving him a couple days and will be resuming another round again this week!

Rated 3 out of 5 stars
By Obiewan on Dec 2, 2021

Great Item

Great item to have on hand i ordered 6 and only recieved 3 though why i gave it a 3 star

Rated 5 out of 5 stars
By Ollie on Mar 28, 2021

General Cure

It really does work to clear up a sick fish. I use it when I have to quarantine a fish and generally it saves them with in one treatment. I highly recommend this as a go to if you are unsure of what is ailing your fish.

Rated 5 out of 5 stars
By star on Dec 31, 2020

Love this product

I just wish it came in smaller doses for smaller tanks. Even 5 gallon would help/ most hospital tanks are 5 gallon

Rated 1 out of 5 stars
By Lena on Jun 19, 2020

Do Not Use on Goldfish or Koi!

I bought some to use because I thought some of my new fish had internal parasites and maybe flukes. They didn’t get any better. By the second day of the treatment (used as prescribed) half of my fish were dead or dying. I’m throwing the rest of the package in the trash! It killed my Shebunkin in the first 8 hours!

Rated 1 out of 5 stars
By Daniel on Sep 28, 2020

Not sealed

Package arrived with a broken seal and powder in the shipping box