API Stress Zyme Freshwater & Saltwater Aquarium Cleaning Solution, 32-oz bottle

Rated 5 out of 5 stars

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About This Item


  • Solution to reduce maintenance and improve the natural aquarium cycle.
  • Contains over 300 million live bacteria per teaspoonful to consume sludge and organic debris.
  • Works to keep gravel, decorations and glass clean.
  • Improves water quality and acts as an active biological filter.
  • Weekly use will help maintain a healthy aquarium.

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Play Video: Learn More About API From Our Team of Experts
Learn More About API From Our Team of Experts

Frequently Bought Together

API Algaefix Algae Control Aquarium Solution, 16-oz bottle
Rated 3.5263 out of 5 stars
$16.99Chewy Price
Total Price: $61.12

About API Water Conditioners

It’s Smart To Be Proactive!

The best way to keep your aquarium clean is to maintain good water quality. This will help keep your fish strong and vibrant and prevent disease. Water conditioners and test kits from API can help you keep your aquarium water safe and healthy.

How Do I Maintain a Healthy Environment?

It is important to test your aquarium water weekly to ensure it stays healthy for your fish.  In addition, a bi-weekly partial water change of no more than 25% will help reduce toxic buildup, remove debris the filter missed, and replenish the oxygen available to your fish.

Feed Twice Daily and Test Water Weekly

Feed your fish twice a day, check their water temperature, and observe them to make sure they are active. You should also test water quality weekly for optimal safety. For fish to thrive, their water must closely match that of their natural environment—poor water quality can cause stress, illness and even fish loss. The 6 important parameters for healthy aquarium water are ammonia, nitrite, nitrate, pH and water hardness (GH & KH). All of these can vary over time and are invisible to the eye.

Change Water and Restore the Ecosystem

In a closed aquarium environment, there are no natural rivers or streams to carry away debris and other waste materials. That is why you should replace 25% of your aquarium water every two weeks, making sure to add water conditioner to your tap water to make it safe for your fish. You should also change your filter media and clean your gravel monthly. Adding beneficial nitrifying bacteria with API Quick Start when you do will help restore your aquarium’s fragile ecosystem and avoid disruption.

What Do API Products Do and When Do I Use Them?

API Test Kits

Use test kits weekly to monitor water quality parameters, which can vary over time and impact the health of your fish.

API Stress Zyme

Using this every week will help keep your aquarium clean and your gravel and ornaments sludge-free.

API Algaefix

Use weekly to control algae growth and keep aquarium glass, ornaments and plants clean.

API Stress Coat

Use every 2 weeks during water changes to make tap water safe, and when adding fish, or when fish are injured.

About API

The team at API has a passion for fish and understands the rewards and relaxation fishkeeping can bring. For almost 60 years, they have developed premium products with a focus on proven and effective results. API offers a range of testing kits, water conditioners and nutritionally superior fish foods. They are dedicated to making a better underwater world for the benefit of fish and those who keep them.

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Fish TypeBetta, Bottom Feeder, Cichlid...Marine Fish, Marine InvertebrateMarine Fish, Marine InvertebrateBetta, Bottom Feeder, Cichlid, Discus, Goldfish, Tropical FreshwaterMarine Fish, Marine Invertebrate
Aquarium TypeSaltwater, FreshwaterSaltwaterSaltwaterFreshwaterSaltwater

Questions & Answers

2 Customer Questions

My daughter has gold fish and two water turtles. Their tanks re always cloudy. What can she use to keep them from getting cloudy even after changing water. She used bottled water but the tanks still get cloudy.
Answer by ChewyMay 19, 2020
For water clarity we recommend the API Accu-Clear Freshwater Aquarium Clarifier.

Does this work good for sand aquariums?
Answer by ChewyJun 19, 2019
This solution works to keep gravel, decorations and glass clean.

ReviewsWrite a Review

Rated 5 out of 5 stars
2 Ratings
Would recommend to a friend

2 Customer Reviews

Rated 5 out of 5 stars
By Carol on Dec 5, 2023

Fish and Cat Bowl

Stress Zyme Plus is the best, can't add new water without it. My cat loves the change of height for his food dish

Rated 5 out of 5 stars
By bernie on Mar 29, 2020

stress zyme

Best stuff to keep your aquarium clean and fish healthy. With a 50 gal tank of gold fish, we use a lot of this stuff and this is the most economical size And of course, CHEWY is the place, most economical to order from