Bio Spot Active Care Flea & Tick Spot On for Dogs, 61-150 lbs, 3 treatments

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Bio Spot Active Care Flea & Tick Spot On for Dogs ensures continuing long-term protection for your pet. Bio Spot Active Care topical gel kills adult fleas and ticks and contains an insect growth regulator to kill flea eggs and larvae for up to 30 days. Included applicator helps keep the liquid off your hands, makes it easier to part your dog's fur, gets liquid down to your dog's skin and is easy to load and apply.

Key Benefits

  • Includes Bio Spot Smart Shield Applicator which helps keep the liquid off your hands, makes it easier to part your dog's fur and gets liquid down to their skin
  • For use on dogs and puppies 12 weeks of age or older that are 61-150 pounds
  • Kills fleas, flea eggs, flea larvae and deer ticks for up to 1 month. Also kills mosquitoes that may transmit disease and virus
  • Fast-drying formula contains a coat conditioner for a non-sticky application, and works with the biology of your dog by spreading through the oils of their skin
  • Formulated with an Insect Growth Regulator (IGR) to break the flea-life cycle

Additional Details

DO NOT USE ON CATS. Keep cats away from treats dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian. Do not allow children to apply this product. Do not use more than one tube per dog/puppy and do not treat more than once per month. Do not allow your dog/puppy to ingest this product. Do not bathe your dog 48 hours prior to application.

Active Ingredients

  • Etofenprox 50.00%
  • Piperonyl Butoxide 9.10%
  • N-octyl bicycloheptene dicarboximide 0.91%
  • Pyriproxyfen 0.45%
  • (S)-Methoprene 0.23%

For Bio Spot Defense Refill, Click here.

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  • Item Number
  • Breed Size
    Large Breeds, Giant Breeds
  • Lifestage
    Adult, All Stages


  • OPEN: Use finger scoop to lift open green door.
  • LOAD: To load, place tube white side up into the open Smart Shield applicator with front of tube placed under tab on door. Ensure that tube fits securely in the Smart Shield applicator.
  • CLOSE: Gently close the green door and the tube will snap open.
  • APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog’s/puppy’s skin. Press circle on green door once at each of four or five evenly placed spots, for large or extra-large dogs (or at each of two to three evenly placed spots for medium or small dogs) between the shoulder and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog’s/puppy’s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy 12-24 hours after treatment will help to distribute the material over the skin.
  • DISPOSE: When finished, hold the Smart Shield® applicator over trash. To dispose of empty tube, open green door and drop empty tube into trash or offer for recycling if available. Close applicator device door and store in original package.
  • RETREAT: Do not reapply product for 30 days. Do not treat more than once per month.

The 3-Step Solution to Pest Prevention

Bio Spot follows the philosophy that pest-free is the way to be—and that's why they offer full coverage for your dog, your home and even your yard. Arming you with everything it takes to keep fleas, ticks and other pests away, Bio Spot is proactive care made easy. In fact, many of their products contain the Infest Stop ingredient, which safely kills flea eggs and larvae before they ever develop into breeding adults.

The 3-Step Solution to Pest Prevention
Protect Your Dog

Protect Your Dog

Pull out every stop against fleas, ticks and even mosquitoes with Bio Spot's variety of treatment and prevention options. Including spot-on applications, collars, sprays and shampoos, Bio Spot has a solution that fits every need and lifestyle. And the best part? They all offer continuous, long-lasting protection to stop the life cycle in its tracks.

Defend Your Home

Pests don't just live on your dog—they live in your home too. And with that in mind, Bio Spot offers defense on the home front. Including a spray that reaches just about everywhere, and a carpet and upholstery powder that controls re-infestation for up to a year, Bio Spot keeps uninvited guests from getting comfortable.

Defend Your Home
Guard Your Yard

Guard Your Yard

The final step in the process, the Bio Spot yard and garden spray takes care of pests at their source. Great for your lawn, trees, shrubs and flowers, the spray is easy to use by attaching to a hose and covering up to 5,000 square feet in no time flat.

About Bio Spot

Bio Spot aims to care for your pet from nose to tail. They know that cats and dogs deliver unconditional love, and that pet parents want to give them the best in return. That's why all Bio Spot products are created to proactively care for their health and well-being—because a healthy and active pet is a happy pet. And happy pets make happy homes.

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About Bio Spot

Customer Reviews

49 reviews 49 Reviews 3.5 out of 5 Stars

71% Recommend

71% of reviewersrecommend this product

3.5 / 5

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  • Bio Spot flea and tick for dogs

    By on

    I have been using this product for over 15 years and it works great. I love the price too, because we have 6 rescued dogs and buying a product like Bio Spot can be very costly. I have tried other spot on flea and tick products that cost a lot more, but Bio Spot flea and tick spot on for dogs works really great!!!

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  • Ineffective for fleas

    By on

    When my dog started scratching I thought it must be allergies or dry skin... It never occurred to me it could be fleas as I kept him treated with this product. Now we've spent a ton of money trying to get fleas out of our couch and home and my pup has been banished from the carpeted rooms until we're sure we've conquered the nasty little critters. I spent the money on this product so we wouldn't have this situation. Not happy.

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  • I had high hopes

    By on

    Time for flea treatment, she was showing signs of fleas, we walk in woods. Gave flea treatment, next day she had six fleas on her, killed them and waited, found four on her and one is her ear flap. I'm done, I was more interested in the mosquito part. That did nothing too! very disappointed

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  • Not satified

    By on

    Applied to each of my 4 dogs. After one week they still have fleas. Would not buy this product again. I have like products from this company before so thought is was safe to try, but I am quite disappointed with the results of this. Very unaffective.

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  • My Bio Spot review

    By on

    Never has disappointed been using it for several years on the East Coast and the West. Fingers crossed knocking on wood I've never had fleas!

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  • My Dog had a reaction

    By on

    It was my first time using this treatment and my dog Ali had a bad reaction to this treatment and I have to sat I will never buy it again.

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  • Bio Spot for Dogs

    By on

    I have been using this for years with great success. I have never seen one flea or tick on any of my dogs. I have never had any allergic or bad reaction to this. Half the price and works great

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  • I have used this for years

    By on

    I used these with my last dog and worked great now I am using it on my new boy and it is working just as well for him. My last dog was a 100lbs and my current dog is 70lbs. We live in small rule town so lots of open space to run and lots of chances to pick up unwanted bugs so reliable protection is important.

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  • Great Product

    By on

    I think I've seen one flea between three dogs since ive pit this product on. The only downfall, my dogs have a grease line for approx 1-2 after application. I just have to be careful not to touch it, otherwise great product!

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  • Bio spot flea & tick

    By on

    Great flea & tick control. The fact that it covers mosquitos is a huge bonus. I have been using it for years with no reactions to any of the dogs it was used on. So glad to find Chewy!

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