Heartworm disease can be fatal, and it only takes one bite from an infected mosquito3
Heartworm disease is a year-round threat.
Even with routine testing, it can take up to nine months to detect.
Protects against more ticks
Ticks are found year-round, in every part of the U.S.4
Simparica Trio starts working fast, and is approved to kill five types of ticks, while other chewable brands are only approved to kill four.5
Roundworms and hookworms can hurt your dog
Symptoms include stomach swelling, vomiting, diarrhea and dehydration.
Infected dogs can contaminate the home, putting other pets and people at risk.
Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.
Possible Side Effects
The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.
Drug & Food Interactions
There are no known contraindications for the use of SIMPARICA TRIO.
Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.
1. Lone Star tick (Amblyomma americanum), Gulf Coast tick (Amblyomma maculatum), American dog tick (Dermacentor variabilis), black-legged or deer tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus)
2. Roundworms (Toxocara canis and Toxacaris leonina) & hookworms (Ancylostoma caninum and Uncinaria stenocephala)
3. AHS Canine Guidelines 2018. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2018-AHS-Canine-Guidelines-181114.pdf?1542248135.
4. Centers for Disease Control and Prevention. Geographic distribution of ticks that bite humans. http://www.cdc.gov/ticks/geographic_distribution.html. Updated June 1, 2015. Accessed March 19, 2019.
5. How ticks spread disease. Centers for Disease Control and Prevention website. https://www.cdc.gov/ticks/life_cycle_and_hosts.html. Updated January 10, 2019. Accessed March 19, 2019.