Simparica Trio


  • Proven to protect your dog against heartworm disease, ticks & fleas, and roundworms & hookworms in just one monthly dose.

  • Tasty chewable that you only need to give once a month: Demonstrated safe for puppies as young as 8 weeks old, weighing 2.8 lbs or more.

Heartworm disease can be fatal 3

  • Heartworm disease is a year-round threat.

  • Even with routine testing, it can take up to nine months to detect. 

Protects against more ticks 

  • Ticks are found year-round, in every part of the U.S.4

  • Simparica Trio starts working fast, and is approved to kill five types of ticks, while other chewable brands are only approved to kill four.5

Roundworms and hookworms can hurt your dog

  • Symptoms include stomach swelling, vomiting, diarrhea and dehydration.

  • Infected dogs can contaminate the home, putting other pets and people at risk. 

Simparica Trio

Simparica Trio from Zoetis Petcare provides flea, tick and heartworm prevention for dogs, plus targeted intestinal parasite control that lasts for an entire month. Now, you can get full-year protection against fleas and five kinds of ticks, total roundworm and hookworm control, and heartworm prevention with just one tasty, chewable dose a month.

Sarolaner, one of three active ingredients in Simparica Trio, attacks fleas and ticks when they bite your pup, killing them within 24 hours. This prevents flea reinfestation by destroying fleas before they can reproduce, and the month-long protection means any newly hatched fleas die as soon as they try to feed on your dog. It also keeps ticks from passing on dangerous diseases like Lyme by eliminating them before the infection can be transmitted. Simparica Trio kills Gulf Coast, Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from harming your pup. Moxidectin stops heartworm larvae from maturing and infecting your dog, while pyrantel treats and helps prevent hookworms and roundworms at the root.

Give your dog the once-a-month oral treatment that combines heartworm and flea prevention for dogs with unparalleled tick coverage and intestinal parasite control. Getting total protection against the pesky pests that plague your pup has never been easier.

What is Simparica Trio?

Simparica Trio is a tasty, once-a-month chewable tablet for parasite control in dogs. It contains a combination of three active ingredients—sarolaner, moxidectin and pyrantel—that work together to keep your dog free of fleas, ticks, heartworms and intestinal worms.

How does Simparica Trio work?

Sarolaner kills fleas and ticks when they feed on your dog’s blood. It starts to work immediately and usually kills within 24 hours of a bite. This helps to prevent ticks from passing on diseases like Lyme and also prevents flea infestations. Moxidectin, the heartworm prevention medicine in Simparica Trio, kills heartworms in the larval stage so they can’t mature and endanger your pup. Pyrantel kills hookworms and roundworms in active infections and kills off any newly-introduced ones to provide ongoing protection. It’s comprehensive parasite protection that lasts a whole month.

Is Simparica Trio safe?

The Simparica Trio combo treatment was approved by the FDA and demonstrated safe for puppies as young as 8 weeks and as small as 2.8 pounds. The three active ingredients in it have been in use for several years and are considered safe and effective for the conditions they treat. Consult with your veterinarian if Simparica Trio is a good option for your pup!