Advantage II Flea Treatment for Dogs, over 25 kg, 4 doses

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About This Item

Details

  • This easy-to-apply topical treatment can be used monthly for year-round protection.
  • Paw-fect for dogs weighing over 25 kilograms.
  • Treats lice and kills fleas through contact—no biting required!
  • Breaks the flea life cycle to help treat and control flea infestations in the home.
  • Safe for dogs and puppies ages seven weeks and older.

Ingredients

Questions & Answers

14 Customer Questions

Will this work on dogs that are 100 pounds?

Originally posted and answered on chewy.com
Answer by Chewy • Oct 20, 2025
Yes, this product is intended to work for dogs over 55 pounds.

Is this product safe to have cats around once it is dried/absorbed by the dog? Or does it continue to possibly pose a risk after that for cats

Originally posted and answered on chewy.com
Answer by FranchescaM • Oct 13, 2024
It is safe for cats to interact with treated dogs as long as 24 hours have passed and the area has fully dried. If accidental ingestion by a cat happens, contact your veterinarian.

If I have cats in my house, is it safe to use this on my dogs?

Originally posted and answered on chewy.com
Answer by IyanzaC • Apr 17, 2022
It is important to keep cats away from treated dogs for up to 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.

How many mL's in one dose for 55 pounds and over?

Originally posted and answered on chewy.com
Answer by DonicaA • Jul 16, 2021
Each Advantage II Flea Treatment tube for dogs over 55 pounds, contains 4 milliliters.
Reviews
Write a Review
4.5
Rated 4.5 out of 5 stars
1026 Ratings
Terms & Conditions

511 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By JOANNE on Jan 14, 2026
Originally posted on chewy.com

Not Working At All!

For some reason, this gets better reviews than Frontline. I have been battling fleas for over a year. Yes, I am doing everything I am supposed to. I can’t afford

For some reason, this gets better reviews than Frontline. I have been battling fleas for over a year. Yes, I am doing everything I am supposed to. I can’t afford to give prescription flea meds to 6 cats. However I did use them for 3 months with no results. I should have stuck with the Frontline, as it actually works pretty well for 3 weeks. Not sure when this nightmare will end!

Rated 1 out of 5 stars
By Sondra on Dec 6, 2025
Originally posted on chewy.com

Better than clay, but not good.

Tried this litter to compare to corn litter. Corn litter wins on all accounts. This has urine smell, corn litter no smell. This litter price per bag is lower than

Tried this litter to compare to corn litter. Corn litter wins on all accounts. This has urine smell, corn litter no smell. This litter price per bag is lower than corn litter however corn litter clumps in hard golf size balls and this litter clumps into a softball size glob that breaks apart and sticks to box. Because it uses more litter it is not cheaper than corn litter. I bought 2 bags tried one and returned the other. Only going to use corn litter.

Rated 5 out of 5 stars
By GINA on Nov 6, 2025
Originally posted on chewy.com

Does just what it claims

This brand works on my dog keeps the fleas off a little longer than a month. Now that being said I purchased some on eBay... didn't work as well... purchase more

This brand works on my dog keeps the fleas off a little longer than a month. Now that being said I purchased some on eBay... didn't work as well... purchase more on eBay turns out it was water...yes water. No smell and no taste. Water ! So if you have experienced issues with advantage...The problem isn't the advantage brand the problem is you're getting knockouts that's not real Advantage. You absolutely MUST buy from a reputable place and I do recommend chewy. ADVANTAGE IS ABSOLUTELY FANTASTIC.

Rated 1 out of 5 stars
By Paul on Oct 2, 2025
Originally posted on chewy.com

Unimpressed

We have generally always used Frontline Gold for our dogs, in the battle to control fleas (3 dogs, indoor / outdoor lifestyle). We usually only use during seasonal

We have generally always used Frontline Gold for our dogs, in the battle to control fleas (3 dogs, indoor / outdoor lifestyle). We usually only use during seasonal periods as I'm not a proponent of pumping my dogs with drugs of any kind. But one of our dogs is 13 and I decided to try something new, that may be a little more gentle on his system, given some of his health conditions. Advantage II has actually created more problems. Over the past 2 months, we continue to find fleas on our dogs, my wife and I are getting bitten--where we used to have control over these disgusting little pests, it's now completely out of control. A literal infestation broke out as this Advantage was useless. For now, it's back to daily vacuuming and constant cleaning of dog bedding until we can get our boys back on Frontline and get this back under control. Moral of the story--if you have a med that is working, just stay on it. I do not recommend Advantage II!

Rated 1 out of 5 stars
By Darrell on Nov 2, 2025
Originally posted on chewy.com

Expensive Waste of Money

Was hoping more from this product. We rarely ever have a flea problem. Ever. When we did, we ordered this product and administered to our three dogs. Didn't even

Was hoping more from this product. We rarely ever have a flea problem. Ever. When we did, we ordered this product and administered to our three dogs. Didn't even put a dent in the flea issues. Thanks frontline for taking our money.

Rated 1 out of 5 stars
By Carol on Oct 27, 2025
Originally posted on chewy.com

Dogs still have fleas!

Advantage was actually recommended by my vet’s office. My dogs did not have one day of relief. I’m so upset and tired of fighting fleas. My dogs are just miserable

Advantage was actually recommended by my vet’s office. My dogs did not have one day of relief. I’m so upset and tired of fighting fleas. My dogs are just miserable. And this means another trip to the vet’s office.

Rated 5 out of 5 stars
By Virginia on Dec 15, 2025
Originally posted on chewy.com

Flea med

This was an error, but I have a friend in need and regifted to them. I usually buy just feline products from Chewy

This was an error, but I have a friend in need and regifted to them. I usually buy just feline products from Chewy

Rated 1 out of 5 stars
By Cynthia on Sep 22, 2025
Originally posted on chewy.com

Product didn't work

The Advantage II nor the Advantix worked at all this time. I don't know why or what happened to their formula, but my dogs have fleas now! Plus now in the house!!!!

The Advantage II nor the Advantix worked at all this time. I don't know why or what happened to their formula, but my dogs have fleas now! Plus now in the house!!!! I'm NOT a happy camper whatsoever!! Thankfully, I'm getting refunds on both! Now to fix the problems....ugh!

Rated 5 out of 5 stars
By Kathy on Dec 14, 2025
Originally posted on chewy.com

It took awhile but eventually helped

He was infested for the first time in 5 years but the feral cats have flea s and that's how he got them.

He was infested for the first time in 5 years but the feral cats have flea s and that's how he got them.

Rated 5 out of 5 stars
By Cristen on Jan 16, 2026
Originally posted on chewy.com

Works fast.

Works fast. Split large dose between animals, according to weight.

Works fast. Split large dose between animals, according to weight.