Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count

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About This Item

Details

  • Nutramax Laboratories Veterinary Sciences has been providing supplements for more than 30 years.
  • Only high-quality ingredients are used to ensure your four-legged friend is receiving a safe supplement.
  • Designed to support your pup’s liver with s-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione, a liver detoxifying agent.
  • Uses silybin for better absorption than the standardized milk thistle extract.
  • Support your furry friend’s liver—it’s responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.

Ingredient Information

Feeding Instructions

Instructions

Learn More About Nutramax From Our Team of Experts

Questions & Answers

21 Customer Questions

What is considered a large dog weight wise?

Originally posted and answered on chewy.com
Answer by Chewy • Dec 12, 2025
The tablets for large dogs is intended for dogs weighing 35 pounds or over.

Does this medication come in chewable form?

Originally posted and answered on chewy.com
Answer by Chewy • Jul 19, 2025
These tablets are meant to be given whole and can be swallowed whole or chewed, and it will not affect the efficacy of the product.

Is this tablet chewable?

Originally posted and answered on chewy.com
Answer by Chewy • May 14, 2025
These tablets are meant to be given whole and can be swallowed whole or chewed, and it will not affect the efficacy of the product.

Can the pill be swallowed instead of chewed?

Originally posted and answered on chewy.com
Answer by Chewy • Feb 18, 2025
These tablets are meant to be given whole and can be swallowed whole or chewed, and it will not affect the efficacy of the product.
Reviews
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4.6
Rated 4.6 out of 5 stars
1726 Ratings
Terms & Conditions

712 Customer Reviews

Rated 5 out of 5 stars
By Maplejay on Jan 5, 2026

Very effective

Our dog has been on these pills for about a year, and they have made a noticeable difference. Follow-up bloodwork from our veterinarian has shown the treatment to

Our dog has been on these pills for about a year, and they have made a noticeable difference. Follow-up bloodwork from our veterinarian has shown the treatment to be very effective in bringing our dog’s levels to where they should be.

Rated 5 out of 5 stars
By Laurie on Aug 8, 2025

Chewy Saved the Day!

When our vet advised Denamarin wasn't available, we were thrilled to find it readily available via Chewy. At a lower price point. Thanks so much Chewy!

When our vet advised Denamarin wasn't available, we were thrilled to find it readily available via Chewy. At a lower price point. Thanks so much Chewy!

Rated 5 out of 5 stars
By cindy on Jan 19, 2026
Originally posted on chewy.com

Liver supplement

My 15 year old dog seemed to be ready give out on me. He was not eating, he was very tired, and feeling weak. We took him to the vet to find out he had liver problems

My 15 year old dog seemed to be ready give out on me. He was not eating, he was very tired, and feeling weak. We took him to the vet to find out he had liver problems. We started giving him this supplement for the past month and he's like his old self again. So happy these worked! He's eating whole meals and acts like a puppy again when he runs into the neighborhood dogs.

Rated 5 out of 5 stars
By Michelle on Jan 14, 2026
Originally posted on chewy.com

Helping our daughter’s liver

Mya has had higher than normal liver counts that made all of us including her vet very concerned. Due to another medical problem, we were able to se how well this

Mya has had higher than normal liver counts that made all of us including her vet very concerned. Due to another medical problem, we were able to se how well this medication worked lowering her levels drastically! We are highly impressed!

Rated 4 out of 5 stars
By Christy on Jan 1, 2026
Originally posted on chewy.com

My pup took this right out of my hand!

My Vet recently told me to give this to my pup to see if it would lower her elevated ALP score. I can’t speak to that yet but I wanted to say that she eats it whole

My Vet recently told me to give this to my pup to see if it would lower her elevated ALP score. I can’t speak to that yet but I wanted to say that she eats it whole. No problems there. I give it to her an hour before breakfast. Will report back in once she is retested. Maybe the product gets its fifth star then.

Rated 4 out of 5 stars
By Amanda on Jan 5, 2026
Originally posted on chewy.com

Great product

This supplement assists my senior dog with liver failure. I feel like it’s given her more time with us. The only issue is I wish the chewable was offered instead

This supplement assists my senior dog with liver failure. I feel like it’s given her more time with us. The only issue is I wish the chewable was offered instead of the pill-we have a hard time getting her to take it-even wi try treats she picks it out but no issues with the chewable version.

Rated 1 out of 5 stars
By Christopher on Nov 26, 2025
Originally posted on chewy.com

Large Pill, Hard to Give

These pills are LARGE and supposed to be given on an empty stomach, which makes them very difficult to give. After only two days of having to force them down my

These pills are LARGE and supposed to be given on an empty stomach, which makes them very difficult to give. After only two days of having to force them down my dog's throat, I gave up. There's no way the manufacturer thought this through or even has dogs of their own. They're supposedly enteric coated, which means they shouldn't be chewed or broken up in any way, meaning the only way to give them is through force unless somehow you have a dog that will swallow anything.

Rated 3 out of 5 stars
By Katherine on Nov 5, 2025
Originally posted on chewy.com

Difficult to administer to my senior dog and made him nauseated

I fully realize Denamarin is the standard of care for dogs with elevated liver enzymes, and if pet owners can make it work for their dog, I'd definitely stick with

I fully realize Denamarin is the standard of care for dogs with elevated liver enzymes, and if pet owners can make it work for their dog, I'd definitely stick with it. But for my dog, since it's supposed to be given on an empty stomach, I had to cram a large pill down my senior boy's throat every morning, as he refused to eat the chewable version. Getting the pill down him got progressively more difficult, it got to the point where it was just a huge battle we both dreaded. Also, about half the time I got the pill into him, he'd vomit within a half an hour. It clearly was making him nauseated, as he started refusing his food as well. So I finally quit giving it to him and switched to a liver supplement without SAM-e, which can be given in a pill pocket with food. I'm guessing it's not as effective, but the Denamarin just wasn't going to work for him.

Rated 1 out of 5 stars
By Erika on Nov 18, 2025
Originally posted on chewy.com

Liver supplement

I purchased this for my senior dog after reading up on heartworms and high ALP. My senior girl was diagnosed heartworm positive and I’m doing the slow kill method

I purchased this for my senior dog after reading up on heartworms and high ALP. My senior girl was diagnosed heartworm positive and I’m doing the slow kill method since she’s 13.5 years old and was paralyzed a year ago from IVDD. The treatment would be too hard for her. I gave her these pills for 4 days and she vomited the next morning every single day. I discontinued them. Important to note that they go bad after 30 days once you open it too. It didn’t work for us but hopefully for others!

Rated 5 out of 5 stars
By Tami on Dec 12, 2025
Originally posted on chewy.com

I was skeptical but it works

This product was recommended by my vet because of elevated liver enzymes. This product is not inexpensive but the health of my dog is worth it and to my surprise

This product was recommended by my vet because of elevated liver enzymes. This product is not inexpensive but the health of my dog is worth it and to my surprise his last blood test all of this liver enzymes were back in range.