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Advantage II Flea Treatment for Small Cats 5 lbs to 9 lbs & Ferrets

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Advantage II Flea Treatment for Cats 5 lbs to 9 lbs & Ferrets is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. It can also be used for ferrets 10 weeks and older and weighing 1 lb or greater. Advantage II for cats & Ferrets contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Safe to use on ferrets 1 pound or greater
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing 5 to 9 pounds. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


Cat Weight Advantage II
2 to 5 pounds Kitten
5 to 9 pounds Small Cat
over 9 pounds Large Cat

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Customer Reviews

Advantage II Flea Treatment for Small Cats 5 lbs to 9 lbs & Ferrets is rated 4.7 out of 5 by 264.
Rated 5 out of 5 by from works right away, no side effects observed I started letting my cats outside. It wasn't long until they brought some critters in with them. I didn't use any product to prevent fleas as I wasn't sure how I felt about putting insecticide in my cats bodies. Very naïve! This product is easy to apply and I have not noticed any side effects. It started working right away (dead fleas on the bedspread the following morning). If you are buying this to treat fleas (not just prevention) you may need to apply more than once a month for a few months, not because the product doesn't work but because you'll have to battle the full life cycle of the pests which can make a home anywhere in your home. I noticed new fleas after the first three weeks of application (they were still dying but were hatching somewhere!). I have since applied two doses spaced two weeks apart which is safe according to the label (can apply again after seven days). My cats did not display any adverse side effects. I definitely recommend this product.
Date published: 2017-01-22
Rated 5 out of 5 by from Works great! Applied Advantage on the back of my cat's neck as directed. Was pleased that it doesn't give off a very strong smell unless you stick it right up next to your nose (easier to sneak it onto my cat haha). As with any flea medication, my cat was not pleased once she felt the liquid on her skin but I was easily able to apply the whole dose. You're definitely going to want to let it dry though before touching your cat because it's rather greasy to the touch. Within the next few hours the fleas dropped dead onto her blanket. She has had no adverse reaction from the product either so it's a win-win! Will definitely restock once I run out in a few months.
Date published: 2017-01-19
Rated 5 out of 5 by from The Best I recently got a cat from the SPCA. Unfortunately, she brought along a couple of friends of the flea variety. I had some Frontline that I had used one time on my previous cat (RIP) when I realized she wouldn't let me try to comb her - and it did NOTHING! I went online and did a search to see if there was something comparable to the K9 Advantix that I use on my dog - and thought I would give this a try! The cat flea treatment is as good and the flea and tick treatment I use for my dog. Now - if they could only find a way for me to apply it without getting her mad at me!
Date published: 2016-12-29
Rated 5 out of 5 by from Works Tried cheaper brands and they don't work , this does I am very happy with my purchase and so is my cat,
Date published: 2017-02-07
Rated 5 out of 5 by from Fast working Delivered within 2 days. Recently took in stray kitten,who had fleas and eggs. I applied this and started working within a few hours. i could see dead fleas clinging to her fur. Also applied it to my 3 other cats,to prevent the fleas spreading
Date published: 2017-01-19
Rated 5 out of 5 by from Cost of Product I always use this product and highly recommend the product. I thought that perhaps by purchasing it through Chewy, that I might get a better price for the item.
Date published: 2016-12-28
Rated 5 out of 5 by from A great price You can buy this product anywhere...but thus was the best price I found. This company delivers super fast too! This was my first purchase and I'm pleased!
Date published: 2017-02-06
Rated 5 out of 5 by from Pricey but worth it! I ordered this 4 days ago and it was delivered to my door this morning. I applied it to my 2 flea infested cats, left the house for a few hours, and when I came back there were no living fleas in sight. I saw a couple of dead fleas on their chins. They aren't scratching as much. The cats seem to be quite happy with their new found relief! More playful and social than usual. I am very satisfied with Advantage II. My cats had no negative reactions to this product. Just try to apply it very high on your cat's neck to avoid them licking it off. Also, if you have multiple cats, separate them so they don't groom each other. By the end of the day, the medicine will be completely absorbed and dry. There are no weird smells. I will also be applying the dog version of this brand to my pit mix tomorrow (after she gets cleaned and her natural oils come back). I'll write a review on that as well.
Date published: 2016-10-30
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