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Advantage II Flea Treatment for Small Cats 5 lbs to 9 lbs & Ferrets

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Advantage II Flea Treatment for Cats 5 lbs to 9 lbs & Ferrets is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. It can also be used for ferrets 10 weeks and older and weighing 1 lb or greater. Advantage II for cats & Ferrets contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Safe to use on ferrets 1 lb or greater
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing 5 - 9 lbs. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

  1. Advantage II Use & Care Instructions


Cat Weight Advantage II
2 - 5 lbs Kitten
5 - 9 lbs Small Cat
Over 9 lbs Large Cat

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Customer Reviews

304 reviews 304 Reviews 4.7 out of 5 Stars
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94% Recommend

94% of reviewersrecommend this product

4.7 / 5
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    By on

    First thing you need to know - if you have a lot of fleas it's going to take some time. You don't just have adult fleas, you have eggs and larvae that were there before you started the treatment. It's going to take about ten days before the life cycle of the flea is completely broken. You will notice an immediate reduction in scratching. You will need to vacuum, clean bedding, and so on. You can make a good flea repellent with essential oils of lavender, lemongrass, and eucalyptus in water. Spray it on everything, including yourself to keep the little bloodsuckers off until the life cycle is broken.

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  • Good for tiny cats

    By on

    My husband and I really struggled to find flea medicine that would accomodate our tiny cat (6lbs) as we found that a lot of flea medicine started at 7lb or 8lb. I asked my vet and they said advantage was a safe brand so we're extremely happy. We haven't seen any fleas on our pets or in the house.

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  • Still have fleas

    By on

    I gave this to my 2 indoor cats who got a few fleas from my dog(who hasnt had fleas in a while now) and both of them still have fleas less than half a month later. Maybe the one I got was a dud, but I'm not happy with this product so far..

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  • Best of the Best

    By on

    This company is so friendly and you can depend on them for excellent prices and supper good shipping. I am so glad I have found this company as I cannot shop any more and this is a service sent from heaven. :)

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  • Flea infestation last year

    By on

    As usual Chewy delivers fast and free. Have four outdoor Barn cats, and last year the fleas were the worst I have ever seen. We used advantage 2 on all the cats already. So far none of them seem to have fleas. Of course summer has just begun and only time will tell. Either way Chewy had the best prices and got it to me quickly. Thanks

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  • Awesome product

    By on

    This worked great for my cats. Gonna try the k9 stuff for the dog since this worked better than frontline did. Also, we received the product way sooner than expected.

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  • Works on larger indoor cats, too

    By on

    I have 9 indoor cats, and have to cut "cat expenses" where needed. I have tried numerous flea medications (including collars) and, for the dollar, this stuff, in my opinion, gives the best flea protection- even on our pair of 15 LB fluffy cats.

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  • Works well

    By on

    We haven't found any ticks or fleas so far, seems like it has done a good job. I know it doesn't really matter, but the packaging is nice too, everything is easy to open. It also comes with stickers to put on a calendar to help keep track of dates.

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  • Ineffective

    By on

    I have several cats. When i purchase flea prevention i need it to work! I put it on my cats immediately.! It's been over a week and I'm combing live fleas off of them! WHY? It's expensive and SHOULD WORK!

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  • No prescription flea stuff...get what ya pay for

    By on

    Hadn't used this flea treatment for years...can't afford Revolution any more. Cats still scratching.

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