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Advantage II Flea Treatment for Large Cats Over 9 lbs

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6 treatments
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Advantage II Flea Treatment for Cats Over 9 lbs is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. Advantage II for cats contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen)
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing over 9 pounds. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

  1. Advantage II Use & Care Instructions


Cat Weight Advantage II
2 - 5 lbs Kitten
5 - 9 lbs Small Cat
Over 9 lbs Large Cat

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Customer Reviews

736 reviews 736 Reviews 4.7 out of 5 Stars

96% Recommend

96% of reviewersrecommend this product

4.7 / 5
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  • Just give it a try!

    By on

    I was a little skeptic having used this once when my cats flea problem wasn't so bad so I couldn't really see a difference and decided not to give her the full three treatments. Since I stopped, the flea problem got worst and she started to bald with her constant biting and licking - the tip of her tail having lost all its hair. Decided to get the 4 pack this time and by the time she was due for her second treatment I noticed her tail was no longer bald! Which means the fleas are dying and this stuff actually works as long as you give it the chance to!

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  • So Easy it is Sinful

    By on

    This is a great flea control method that I can get at my Vet's office and/or almost all pet stores. Buying it from Chewy allowed me to save a great deal of money and it arrived at my front door in perfect condition. Using Chewy.com is really so easy it seems wrong. I wish everything in life was this easy and this professional! I will never buy pet products anywhere else!

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  • Flea Treatment did not work

    By on

    This treatment was administered as directed but it did not work this time. After a couple of weeks we are still seeing fleas on the cats. Not sure if it is a bad batch or there is an immunity issue going on. We purchased for large and small cats and also for a large dog. All are still miserable, including us. This is quite expensive when you're treating a total of 7 cats and 1 dog, and then to have them still biting and scratching.

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  • Unsure about this product

    By on

    I researched which flea medication to use on my cat due to his age and health condition. Advantage II was rated the best for taking care of fleas without having negative interactions with his condition. It's been over a week since I gave him the ADV II and he's still scratching, just like he did with the Frontline. It seems like I wasted my money, but I'm willing to give it time and see what happens after next month's dose. Either way, the product doesn't seem to work as described.

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  • Eh it was ok

    By on

    I bought the cat version AND the dog version of Advantage II and treated my indoor cat and my dogs. All saw relief within 2 days. Unfortunately, the treatment seemed to wear off about a week and a half early and when I treated them on month 2, the fleas just keep getting worse daily.

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  • No more bad reactions!

    By on

    My cats have had local sensitivities to other topical flea treatments in the past, so I was skeptical that this would work. I didn't want to spend tons of money for the vet prescribed medicine either, so I gave it a try. After treating all three of my cats with Advantage II, none of them had the reaction that had occurred before with other brands. And the fleas are gone in less than two weeks! Thanks for making a great product!

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  • Great for kitties with sensitive skin.

    By on

    We have 3 cats, one of which is super sensitive to most topical flea treatments. This was recommended by our vet as effective flea and tick prevention for his sensitive skin. It is extremely effective, even on our cat that weighs 20+ lbs, and does not cause any skin irritation.

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  • Definitely works

    By on

    It's been 1 week since I gave both my dog and cat a flea bath and then applied this product to both of them. We are still finding random fleas here and there through the house, but there are none on the animals. I have faith that if we keep using this we will soon be done with the fleas completely.

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  • great product

    By on

    although this is NOT an instant fix, but by being consistent and applying this every month, it does work. if you already have an infestation this will help to REDUCE but you need to wash everything, bedding and all. carpets, couch everything needs to be addressed. even though your pet may not be an outdoor animal, you yourself can bring them into your home. I know I've been there! a couple of times. get ahead of the flea season before the season. that has always been my trick. and just because it's winter and you don't see fleas, trust me they are still around. you have to be vigilant, persistant, and on top of it always. remember this is a monthly dose, do it monthly!

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  • Worked very well the first try!

    By on

    This product definitely worked really well the first time. My cat has had a history of fleas for awhile and this cleared it up! I was very shocked when the medicine was very liquid-y. The flea medication we used before was gel typed so this worked real well!

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