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Advantage II Flea Treatment for Large Cats Over 9 lbs

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Advantage II Flea Treatment for Cats Over 9 lbs is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. Advantage II for cats contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen)
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing over 9 pounds. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


Cat Weight Advantage II
2 to 5 pounds Kitten
5 to 9 pounds Small Cat
over 9 pounds Large Cat

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Customer Reviews

Advantage II Flea Treatment for Large Cats Over 9 lbs is rated 4.7 out of 5 by 534.
Rated 5 out of 5 by from Works wonderfully Advantage is the only flee preventative I use! A few years ago flees got in the house we are not quit sure how since non of my cats go out side! I have 7 cats, in a weeks time our basement which is also our bedroom we couldn't go down in they were so bad. To add to the problem I have 2 Cockatoo's calling an exterminator was out. We used a powder and vacuumed everything. I bought the other brand and it didn't touch the problem. I called Bayer, their customer service person was wonderful. Bayer will refund all money spent on their product if it doesn't work. That is their guarantee. I did as she told me I applied it to all of my cats and did a follow up in 2 weeks the flees were gone. FYI it is safe to apply this product with in 2 week of the first application to kill the flees in your home if you have the same problem I did. Large parrots. After that we have not had flees at all. I highly recommend this for any cat owner that has indoor only or inside/outside cats.
Date published: 2016-10-03
Rated 5 out of 5 by from It works. I had heard that these "over the counter" flea meds were no longer effective. I put it on both of my cats, who had visible evidence of fleas (saw flea droppings on my bathroom floor and toilet). I tried combing the fleas off but realized over a short period of time I was going to have to use a product. Since the first application of Advantage, I have not seen any more "evidence" of fleas. I haven't tried combing them again, but I am trusting all the fleas are on their way out. I used Advantage years ago when it was dispensed by my vet and was always satisfied. Chewy.com is my new go to pet store. Their prices are SIGNIFICANTLY less than other stores. This particular product was $20 less, other cat food I purchased was at least $20 less in total. They had an awesome $15 coupon for new customers too. And I was able to sign up, at a discount, for monthly delivery of products...which will always be over $50 so shipping will be free. And the two day promised delivery...it's true!!! This is an honest review, I was not in any way compensated for these comments. Very pleased with this company and look forward to doing future business with them.
Date published: 2016-12-26
Rated 5 out of 5 by from Great website company Really no Kitty wants to have this stuff put on them but it needs to be done at times. So all Kitties would review this "as yuck get it off me" LOL as for me as a customer i highly recommend this product but most of i recommend this website company i have seen their prices beat so many others in large leaps and bounds very quick with shipping and so easy to deal with along numerous aspects. once again "great company thanks for being here for all us animal lovers"
Date published: 2017-02-26
Rated 5 out of 5 by from Best effective Flea Control Product on the market. I have used Advantage, on my cats ever since the product first came out. Flea powders were not effective and also "trailed" throughout areas they frequented. Flea Collars caused Raw Areas around the necks of my cats. This product is the safest, most efficient product I have ever used. CHEWY. COM processed and delivered my order promptly, courtesly and efficiently.
Date published: 2017-01-27
Rated 5 out of 5 by from Cats: 1, Fleas: 0 We've always had good luck with Advantage. Recently we went back to trying the flea collars -- it might as well have been a cologne as the fleas continued to party like it was 1999 (I swear I could even hear Prince singing away late at night.) Broke down and bought the good stuff -- which we should have done so originally. No more scratching and no more fleas. The cats seem happier with not having to itch themselves every two minutes and I'm happier knowing the cats feel better . . . not to mention it's always nice to be able to watch TV without being joined by one or two fleas who also want to catch the game on the TV.
Date published: 2016-09-26
Rated 3 out of 5 by from Ok start When my indoor cats got a nasty case of fleas out of nowhere, this stuff worked great for about a week or so. With vacuuming the scratching stopped but resumed about 2 weeks later. I started applying a household spray for all stages of flea life cycle after it was clear the flea drops weren't enough. Things are more under control from using the pesticide spray than this stuff. Advantage II is good for getting cats immediate, temporary relief from itching but you shouldn't expect more. Best bet: apply flea control, vacuum AT LEAST 1x daily and, most importantly, treat the house and pet bedding with spray that deals with eggs, larvae and adults. Be prepared to deworm too.
Date published: 2017-02-10
Rated 5 out of 5 by from BYE BYE FLEAS I almost never write reviews but this product deserves one. My indoor cat got a nasty case of fleas. I decided to give advantage II a try. It arrived the next day so I parted the cat's fur as instructed and applied the product. The day after I applied the advantage II, I combed out just a few live fleas and a lot of dead ones. Day two after I applied it, I combed and combed but the only "live" flea I could find was just barely alive. My cat is back to enjoying log naps without being startled awake by flea bites.
Date published: 2017-02-18
Rated 5 out of 5 by from Fabulous product I have 4 indoor cats and 2 dogs. I have been fighting a medium flea infestation since October (it is now January). Within 2 hours of application of Advantage, fleas were jumping off my cats. I vacuumed several times the first 24 hours and then put table salt on my floors before bed and have vacuumed daily for 3 days, I can say I am 95% flea free. Advantage for cats is the best. ( I used something else for my dogs.) I am thrilled beyond words.
Date published: 2017-01-25
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