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Advantage II Flea Treatment for Large Cats Over 9 lbs

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Advantage II Flea Treatment for Cats Over 9 lbs is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. Advantage II for cats contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen)
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing over 9 lbs. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

  1. Advantage II Use & Care Instructions


Cat Weight Advantage II
2 - 5 lbs Kitten
5 - 9 lbs Small Cat
Over 9 lbs Large Cat

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Customer Reviews

821 reviews 821 Reviews 4.7 out of 5 Stars

96% Recommend

96% of reviewersrecommend this product

4.7 / 5
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  • We saved SO much money!

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    As I wrote on my review for Advantage II for dogs, we experienced our first flea problem in 22 years. I was terrified of treating the cats, because I'd heard horror stories. But when our vet recommended Advantage II I felt more confident. The prices at the vet and our local stores were scary expensive - and we have three cats, that need to be treated for three months. I discovered Chewy had the best prices of all. The pleasant surprise was getting the order in two days! The fleas are almost gone, our cats and dog are perfectly fine and everybody's happy.

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  • Works fast and quickly.

    By on

    I put this on all three of my cats, had to be tricky about it because they are cats, but it worked! After 1 day I didn't see a flea and so far, 2 weeks later, still flea free. I've tried other products in the past and they only temporarily reduced the problem, after a few days they were back. Wish I tried Advantage sooner. I got the Advantix for my dog and that worked great also.

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  • Works so far

    By on

    I have 3 indoor cats. Because I do a lot of work outside in the yard, occasionally a flea will hitch a ride back in. The first two times I treated them with Advantage II and it took care of the problem, but I made the mistake of only treating for a couple months then stopping. Eventually it happened again. So now, going on 2 years, I've been treating them every month with this product and have had no more flea issues. Don't know how it works on outdoor cats, but for my purpose it works great. Also, Chewy has awesomely fast delivery, just throwing that out there.

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  • Works Magic

    By on

    Super impressed with how quick and effective this product was at killing fleas. My poor cats had a little outbreak (not surprising, since my husband let them outside...). As soon as we noticed we ordered Advantage II, had it overnighted, and applied it as soon as it arrived. Within 16hrs the cats stopped scratching, and after we brushed them to death, we found no further evidence of flea dirt. Yay! It was also super easy to apply.

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  • Finally!!!

    By on

    Thank goodness I've finally found a flea product that actually works, and fast!! Have tried probably everything else out there and nothing worked. Now that all of my 6 inside cats are 9lbs or more, I decided to try Advantage II. Success at last! Thank goodness for Chewy too, as I received my order the next day. Applied it as soon as I got home from work and by the next morning the constant licking and scratching had stopped and my cats were lying around peacefully. I've still been using a flea comb on them a couple times a day to doublecheck and the fleas are gone, the cats are happy and so am I.

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  • cat flea infestation

    By on

    Advantage II flea treatment for large cats worked like a charm and completely eliminated all fleas on my 2 indoor cats the first night I applied the treatment. These are long-haired cats, Maine Coons. A month later they remain flea-free, but I plan to give them one more treatment for good measure. I had been using Frontline for the past year with no success, so this Advantage II is a very good product.

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  • Fleas Be Gone

    By on

    Product worked great on my three very large cats who caught fleas for the first time in their lives at the vet's office when one of them stayed the day after dental surgery. My cats are 16 and 17 lbs. and within a few days no signs of fleas or flea dirt.

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  • Disappointed

    By on

    Product started working in about 5 days, after 10 days.. nothing..my cats are indoors always, no outside pets at all. I bought this hoping it would help with the fleas on my daughters cats also. Same results. Now I'm on the search for another product.. anybody have any suggestions?

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  • Great prices for Advantage 2

    By on

    Best price, most efficient/friendly customer service. Order delivered in one day. Had been using useless Frontline Gold/recommended, sold by vet. Poor kitties scratched/had fleas- like crazy-Advantage works much better for us. Thank you!

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  • Works great!

    By on

    I have been using a number of flea treatment products on my 7 indoor kitties for awhile, with very limited success. My vet suggested Advantage. I ordered both the large cat and small cat versions (I have one 4-month old kitten). It has worked wonderfully on all my cats! Needless to say I am very happy with Advantage.

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