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Advantage II Flea Treatment for Kittens 2-5 lbs, 4 treatments

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Advantage II Flea Treatment for Kittens is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. It contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen)
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing 2 - 5 lbs. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


Cat Weight Advantage II
2 to 5 pounds Kitten
5 to 9 pounds Small Cat
over 9 pounds Large Cat

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Customer Reviews

87 reviews 87 Reviews 4.7 out of 5 Stars

96% Recommend

96% of reviewersrecommend this product

4.7 / 5
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  • great product

    By on

    We rescued three kittens who were approx 4 months old. They were covered with fleas so I knew I needed a fast acting product. I ordered from Chewy's, received it in two days and applied it to all three kittens. There were no side effects, easy to apply and within six hours all three were crashed out on the pillow sleeping soundly. I would recommend this flea treatment to anyone.

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  • Fleas be DEAD!!

    By on

    It's the BEST... I highly recommend it and Chewy has the BEST pricing. We have five cats and we've been using the product for several years. We've NEVER seen a single flea. Our cats do go out in our garden (i.e. very control involvement) several times a month but for the most part they are indoor cats.

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  • Worked great

    By on

    I found my kitty (her name) a couple months ago. She was a stray kitten with no mom and no other known siblings. She had a billion fleas. All stuck to her throat and chin. Her first bath Drew lots of blood. I was having trouble finding something for her age and ..... Well cheap. But I decided to go all out and buy this. It worked so perfectly we where free from fleas for a couple of weeks. My two dogs got fleas from the outside so the fleas are still around but they aren't bugging her anymore. So happy and grateful for this product and for this app! :'( I wish I had this app sooner. Recently started using it for cat supplies tbh

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  • Advantage WORKS!

    By on

    I got this after I discovered that the two kittens that we are fostering had fleas. We used the advantage to treat them as well as our other Critters and within 48 hours our animals and the kittens we are fostering were flea free!

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  • Great product!

    By on

    Works great. I washed my kittens with flea shampoo and applied the advantage treatment. I also used adams home flea spray. With combination of these products over a few days i noticed the fleas were gone. My kittens didnt have any reaction to the products. Im very happy with the results and would highly recommend this it. Its affordable and it actually works.

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  • Does anything really work?

    By on

    While this product reduced the amount of fleas on their heads, it just moved the fleas to to their legs and tails. It was better than nothing, but far from a perfect solution.

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  • Used on a healthy, one year old ferret.

    By on

    My ferret was scratching like crazy and we saw he had fleas. Gave him a bath and the next night applied this advantage ii kittens 2-5 lbs to him. It worked great and he was feeling better and scratching soooo much less. I am very pleased and I will be using this product to address ferret fleas in the future. :)

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  • Good Stuff!!!

    By on

    I'm very pleased with this product and also Very Pleased with chewy.com. They deliver quickly and provide good stuff!!! Highly recommend!!!!

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  • Fleas-1 Kitten-0

    By on

    My kitten still has fleas although not quite as many. I hope it goes better after the 2nd application.

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  • Twin Kittens Flea Free

    By on

    My two new kittens were covered in fleas! Within less than a day of administering Advantage II the fleas were gone. There are no fleas on my kittens or in my home! Great product highly recommend!

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