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Advantage II Flea Treatment for Kittens 2-5 lbs, 4 treatments

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Advantage II Flea Treatment for Kittens is a convenient monthly topical flea medicine for cats and kittens 8 weeks of age and older. It contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your cat to die. One convenient application of Advantage II cat flea treatment keeps working for 1 month.

Key Benefits

  • Contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen)
  • Kills all flea life stages including eggs, larvae, pupae, and adult flea
  • Controls existing fleas and flea eggs and prevents future flea infestations
  • Works through contact, so fleas don’t have to bite to die
  • Provides waterproof protection


For use only on cats 8 weeks and older and weighing 2 to 5 pounds. Keep out of reach of children. Always read the entire product label before using this product.

Active Ingredients

  • Imidacloprid 9.1%
  • Pyripoxyfen 0.46%

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  • Brand
  • Lifestage
  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet’s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your cat’s eyes, or allow your cat to ingest this product. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not allow the product to run off.
  • Discard empty tube.
  • Under normal conditions this product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II provides ovicidal, as well as additional larvicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


Cat Weight Advantage II
2 to 5 pounds Kitten
5 to 9 pounds Small Cat
over 9 pounds Large Cat

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Customer Reviews

69 reviews 69 Reviews 4.7 out of 5 Stars
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97% Recommend

97% of reviewersrecommend this product

4.7 / 5
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  • Works great

    By on

    I tried a cheaper brand (I have several rescue cats). But fleas came back and a few cats started losing fur. Put Advantage II on all of them 4/1. Fleas are gone and fur is growing back. Everybody is happy.

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  • Great product

    By on

    This is the best flea medicine we have ever used. My husband and I rescue cats and have 46 inside cats (we have built large sheds in our back yard to accommodate them). We use this product on them and we never have a flea problem. In fact it is so good we do not have to use it monthly as recommended.

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  • Lifesaver

    By on

    A few weeks ago someone dropped off a baby kitten in the middle of the road so long story short she's now at our house. Guessing at her age & weight I was very hesitant about flea/tick products but after reading the reviews I felt more confident. This product worked almost immediately. I highly recommend.

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  • Glad there is something for kittens!

    By on Top 500 Contributor

    Recently took in a dumped kitten. He was covered with fleas, we have 2 other cats and a dog protected with collars but the kitten didn't meet weight or age requirements. After several baths he still had a lot of fleas, called the vet who told me to get this product. Has worked like a charm.....in just a couple of days no more fleas! If you have one that falls between weight requirements on the package this seems to be a good choice.

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  • Hard to find

    By on

    Not easy to find the Advantage Kitten 2. Chewy had it and at a great price

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  • Cat treatment

    By on

    Good price for the advantage11 for the cats and kitten

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  • Works!

    By on

    Our kittens had bad fleas. Shampoing would only give temporary relief. Advantage II works good. Kittens felt better. It didn't kill all the fleas, but about 85% fleas, eggs and larvae gone.

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  • Worked fast & well.

    By on

    Having 4 small cats that had picked up fleas that were getting out of control, we were relieved to find one with such high recommendations. When 1st applied to the year old, I was concerned. She tossed & turned rubbing all over. It did its job well.

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  • So nice for young kitties!!

    By on

    Thank you for making it affordable and easy!! Prompt delivery and affordable prices!! I just took in3 kittens, gets costly! I really appreciate your prices and constant deals!! Keep them coming.

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  • For use on my rabbit.

    By on

    This is one of the few flea treatments that can be used on a rabbit. It works fairly well.

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