Virbac Knockout E.S. Area Treatment Spray, 16-oz can

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Virbac Knockout E.S. Area Treatment Spray is the inverted aerosol house spray containing pyrethrins and permethrin to kill active flea and tick infestations. Also, contains pyriproxyfen (NYLAR Insect Growth Regulator) to prevent flea infestations from developing for up to 7 months. One 16 oz can covers 2,100 square feet. Knockout E.S. Area Treatment Spray provides rapid relief from active flea and tick infestations. Contains the highest levels of environmental adulticides in an aerosol for maximum effectiveness and quick killing of fleas and ticks. Prevents reinfestation of fleas by stopping immature fleas from developing into the adult biting stage. Reaches fleas hidden in carpets, rugs, drapes, upholstery, pet bedding, and floor cracks for greater effectiveness. No mess. Leaves no unpleasant odor or sticky mess and, when used as directed, does not stain furnishings.

Key Benefits

  • Rapidly kills active flea and tick infestations with active ingredients pyrethrins, permethrin, and pyriproxyfen (an Insect Growth Regulator)
  • Prevents flea infestations from developing for up to 7 months by stopping immature fleas from developing into the adult biting stage
  • Reaches fleas hidden in carpets, rugs, drapes, upholstery, pet bedding, and floor cracks for greater effectiveness
  • Leaves no unpleasant odor or sticky mess, and does not stain furnishing when used as directed
  • Covers and treats 2,100 square feet


Keep out of reach of children.

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    United States


Use one 16 oz bottle of Knockout E. S. Area Treatment for an area up to 2,100 sq. ft. Carpeted areas may be vacuumed before treatment and after treatment has dried. Treat infested areas or areas which could be infested; these include rugs, carpets, upholstered furniture, pet beds, and pet resting areas. Hold can at arm's length and direct spray toward the area to be treated. Use a sweeping motion to apply product and back away from treated area while holding the can 36 inches away from the surface being treated. Areas of 80-100 sq ft can be treated in approximately 10 seconds with Knockout E. S. Area Treatment. When treating upholstered furniture, treat under cushions and areas where flea development occurs. Cover aquariums and fish bowls and remove birds from area prior to treating. Treated areas should be vacated during application. Pets should be treated with a registered product for flea and tick control in conjunction with this product.

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Customer Reviews

Virbac Knockout E.S. Area Treatment Spray is rated 4.5 out of 5 by 49.
Rated 5 out of 5 by from Finally found something that works!! I have three cats,and we have been fighting their fleas for 6 MONTHS!!! They have all been on internal meds (the kind where you put a liquid on the neck and it gets absorbed). I had used a "flea bomb" in their room, washed bedding and vacuumed until I dropped...then I got a recommendation for KNOCKOUT and the results have been amazing. Bought 2 cans "just in case" but only needed one. And it was $10 less expensive than buying it at the vets!
Date published: 2017-02-08
Rated 5 out of 5 by from My big hope My dog and her bed came home with seemingly resistant fleas, from a boarding kennel over labor day week.a nightmare. After washing EVERYTHING washable in my home, clipping cocker really short, flea bathing her, putting advance on her and two cats, vacuuming every surface daily and still finding live fleas, I have sprayed ALL surfaces with this recommended vet and dog trainer. It can/does enter small cracks and spaces, upholstery crevices, under furniture, rugs, every surface possible. It will inhibit development of eggs and larvae into adult fleas for 7 months. Since both cats and dog are showing a few live fleas, they are getting capstar daily as I continue with daily vacuuming. This has been a two week ordeal thus far. Since spraying I am definitely finding fewer live fleas...none yesterday....and less flea dirt using flea comb on animals. The spray has a very acceptable smell which mostly disappears after it dries, and seems safe for surfaces following directions on the can. I can give more definite evaluation as time goes by. All fingers are crossed. I have one cocker spaniel and two cats. Also have put flea collar on dog...these seem to be very resistant fleas having come from a boarding kennel.
Date published: 2016-10-11
Rated 5 out of 5 by from Best room flea spray I've found! This was out of stock for some time, but hats off to Chewy! Received an email notifying me when it was available again.
Date published: 2017-01-08
Rated 5 out of 5 by from Great Product, Period Awesome spray worked great! I had to clean out our rental RV we rented to irresponsible pet owners which we have turned over to the proper authorities. Soon has I walked in ( I had white pants on) the whole bottom of my pants were covered in fleas baby's, teen's & adult's, maybe 100 ez on each leg I shut the rv door I vacuumed them off me . Ordered this spray when it arrived I opened the door saw fleas jumping on my socks pants sprayed the area no fleas gone, dead - biff bang pow! See ya blood suckers!! You got fleas buy this you'll be glad you did must use in conjunction with flea shampoo , daily house and pet vacuuming. If you have pets killed fleas on contact eggs larvae yuk, see ya !!
Date published: 2016-10-23
Rated 5 out of 5 by from Truly AMAZING I was being attacked like crazy, my apartment is all carpeted and getting getting off the bed was a nightmare, id have about 10 miniscule blood suckers on me everytime i walked on the floor. I swear they just seemed to appear in a week. My poor fur babys hated them too. I powdered the floor like 3 times vacuumed and they persisted, i bought a hand spray still they seemed to attack more. Finally after reading reviews i caved in and got 2 of these bottles of virbac knockeout e.s. area treatment spray can 16 oz. Omg this stuff is AMAZING i can walk in my home again and they seem to be gone. Also i treated my cats with capstar pills and it works like a charm, these two products together truely brought peace and comfort back to my home. By the way, i only needed one can for my two bedroom apartment, still im keeping my other bottle for peace mind. Truly amazing stuff. Thank you virbac.
Date published: 2016-06-24
Rated 5 out of 5 by from Great product This product worked well, I tried everything including lemon oil, eucalyptus oil, salt, diatomaceous earth, baking soda, 3 different topical flea treatments, vaccumed religiously everyday and we were still finding fleas- because of the square footage of my home, and unsure where the little guys were living I had to purchase 2 cans to effectively treat the house, it's been 2 weeks and I think we're finally in the clear! I might buy another can to have on handy - worst experience living with fleas in my life- have no idea how we even got fleas due to the fact we have one pet and she is a strict inside kitty- thank you for your product - I couldn't live with fleas in my home!
Date published: 2016-11-16
Rated 5 out of 5 by from Great product!!! I recommend this product 100%. I have used other products but none compare.
Date published: 2017-01-23
Rated 5 out of 5 by from if you have fleas.......YOU NEED KNOCKOUT ES NOW!!! Oh my gosh, what a nightmare, in all of my 55 years of living and always having indoor cats & NEVER having fleas before, this product saved myself from going bonkers in trying to eradicate my home from these uninvited bugs. Works great when you spray everything, under couch cushions, rugs, mattress, every thing you can see where the cats may have been which is EVERYWHERE!!! Also, following a strict routine of washing everything & the most important twice a day everyday for a few weeks VACUUM!!! Throw out bag every time or put flea collar in it & freeze bag until use. The problem with fleas is all the eggs you cannot see. These little bugs were in the cracks of my new wood floor, and trust me I am super clean!! Good Luck & don't worry, once you use this your old life with no fleas will return shortly!!!
Date published: 2014-08-01
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