Centragard Topical Solution for Cats, 5.6-16.5 lbs, (Red Box), slide 1 of 1

Centragard Topical Solution for Cats, 5.6-16.5 lbs, (Red Box), 3 Doses (3-mos. supply)

Prescription Item

  • Price:

    $44.99 FREE Shipping over $49

Autoship: &Save

$42.74(Save an extra 5%)

Simply select Autoship at checkout for easy regular deliveries.

In stock

This item requires prescription approval. Details

Medications ship separately. Delivery times may vary. Details

We'll collect your pet's prescription information at Checkout.

cw-icon-heart Created with Sketch. Add to Favorites

From the makers of Heartgard Plus, Centragard is a broad-spectrum, monthly medication prescribed by veterinarians to help prevent heartworm and help treat and control roundworms, hookworms and tapeworms in cats. This treatment is specially formulated for cats who are seven weeks of age and older and weigh between 5.6 and 16.5 pounds. Best of all, it comes with an easy-to-use applicator, so you can apply the treatment directly to your companion’s skin without any hassle.


Centragard is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis) in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.

Possible Side Effects

In a well-controlled field study emesis, anorexia, lethargy, temporary clumping or spiking of the hair, or mild, transient skin reactions (itching, hair loss) were reported. When cats licked the application site after treatment, temporary excessive salivation was observed. Oral ingestion of CENTRAGARD may also result in hypersalivation, vomiting and/or lethargy. In margin of safety studies, transient neurological signs such as ataxia, disorientation, lethargy, and pupil dilation were observed in some cats. Correct application will minimize the occurrence of such events.

Drug & Food Interactions

Talk to your veterinarian about any other drugs your cat is taking before starting this medication.


Do not administer orally. Cats may salivate excessively and vomit if Centragard is accidentally administered orally or is ingested through licking/grooming the application site (see ANIMAL SAFETY). The safety of Centragard has not been tested in breeding, pregnant or lactating cats. The safety of Centragard has not been tested in kittens less than 7-9 weeks of age or weighing less than 1.8 lbs (0.8 kg).

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Green1.8-5.5 lbs1.2 mg Eprinomectin and 24.9 mg Praziquantel0.3✓-Click Here
Red5.6-16.5 lbs3.6 mg Eprinomectin and 74.7 mg Praziquantel0.9✓-Click Here
  1. Package Insert

See all items by Centragard

  • Item Number
  • For Use With
  • Common Brand Name(s)
  • Generic Name
  • Administration Form
  • Brand
    Boehringer Ingelheim
  • Lifestage
    Adult, Senior, Kitten
  • Breed Size
    Large Breeds
  • Product Form
  • Strength
    3.6 mg Eprinomectin and 74.7 mg Praziquantel
  • Health Condition
  • Drug Type

74.7 mg Praziquantel, 3.6 mg Eprinomectin.

Recommended Dosage

Centragard is dosed at a minimum of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.23 mg/ lb eprinomectin and 4.55 mg/lb praziquantel. Administer the entire contents of a Centragard unit applicator topically once a month as specfied in the following table:

Storage Instructions

Store at or below 86°F (30°C) with excursions permitted to 104°f (40°c). Protect from light.


What parasites does Centragard protect against? Centragard is also approved to treat and control three of the most common intestinal parasites of cats -- hookworms, roundworms, and tapeworms. It is the first, and only, product to protect against this spectrum of parasites in an easy-to-use transdermal formulation.

My cat only lives indoors. Is parasite protection necessary? Even indoor cats are at risk of exposure to these parasites. According to the American Heartworm Society, 1 in 4 cats diagnosed with heartworm disease are indoor only pets.

What is Heartworm Disease? Heartworm disease is a serious and potentially fatal disease that can affect dogs, cats, and other animals. The risk of heartworms is widespread in the U.S. Heartworms are transmitted by infected mosquitoes. Mosquitoes become infected with heartworm microfilariae while taking a blood meal from an infected dog, and then can transmit the heartworms to cats. Once in the cat, heartworm larvae develop in the cat’s tissues and then migrate to the bloodstream. They reach the blood vessels of the heart and lungs in a few months.

What is the best number to call regarding any specific product questions?

For any specific product questions, please call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251.

Rating: 4.0 of 5 stars 11 Reviews 11 Reviews 4 out of 5 Stars

Filter reviews by star rating

82% Recommend

82% of reviewersrecommend this product

Rating: 4.0 of 5 stars 4 / 5

You've Already Reviewed This Item

11 Reviews

Showing 1-10 of 11 Reviews

  • 5 out of 5 stars

    Quick turn around

    By Slang on Mar 17, 2021

    Our Veterinarian recommended Centragard for our indoor/ out door cat who likes to bring us gifts. We live on an old farm with very old barns. We needed Chewy to verify the Rx from the vet which took less than 36 hours and we had the Centragard with in 72 hours of the Vet visit. The auto replenishment will be very convenient as we will not have to make repeated visits to the veterinarian.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    buy it now!!

    By Maddi on Feb 2, 2021

    My cats are prone to eating fleas and getting tapeworms. Yuck. I know. But this product works wonders! I suggest using it monthly, not as a one time thing. Our kitties constantly lick fleas off of themselves (even while on Advantage II) and occasionally swallow one. THIS PRODUCT WORKS!

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Getting the preventive medicine was much easier than I expected

    By NamuReward on Sep 21, 2020

    Getting the preventive medicine for my indoor/outdoor (daytime) beloved cat was much easier than I expected. Just a click, my Vet found in their list, and Chewy took care of the rest. Lori

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Great Service!

    By Deedee on Dec 13, 2020

    Easy to use on my cats. They are hard to catch, but was so easy to apply.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Awesome medication

    By Cats on Apr 23, 2020

    I was prescribed this from my vets and my cat was rid of the worms within a few days it seemed. He is an outsider/inside cat. He loves to hunt big and small game.. this helps him stay safe

    You liked it! Something went wrong. Please try again later. Report
  • 1 out of 5 stars

    Total Waste of Money

    By Catscatscats on Jan 9, 2020

    My vet prescribe this for tapeworms in two of my cats. It is an expensive product so I expected it to work. It didn’t work at all, and we had to revert to an injectable dewormer. Don’t waste your money or let your vet prescribe this to you.

    You liked it! Something went wrong. Please try again later. Report
  • 1 out of 5 stars

    Still has worms

    By NMock on Oct 14, 2019

    Not even a week later, my precious cat still has worms. This medication is NOT effective at all in treating and preventing tapeworms.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    This stuff is GREAT

    By QualityOfLifeRehab on Jun 17, 2019

    I love this product. We have had several cases, in our rescue, that were challenging. The cats simply were NOT gaining weight. We had dewormed them and yet they were still in rough shape. We were advised to try CentraGuasrd by our veterinarian, Dr Emily North... and it is AMAZING! The cats we have used it on get progressively healthier. You start to see improvement within days. They gain weight and the coat becomes softer. It is topical and kills all worms in cats (except heart worms). I wish we could afford to use it on every rescue, every month!

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Tapeworms treated and prevented topically?! Still need flea control though

    By ChoosyPetProtector on May 24, 2019

    Geriatrics hunting rodents/rabbits get non-flea tapeworm, Centragard prevents infestation. Controls what internal parasites Heartgard does, in addition to tapeworms (a flatworm parasite) carried by fleas, and those carried by rodents/rabbits, all in a topical medication. Easy to administer compared to dull chew treat of Heartgard the cats snub in favor of their wild prey and kitty crack kibbles.

    You liked it! Something went wrong. Please try again later. Report
  • 4 out of 5 stars

    Easy Peasy

    By CorpusSun on Jun 3, 2019

    Our old product for parasite prevention wasn’t working for fleas anymore, so we switched brands and the new one only does fleas. I can’t depend on my cats to eat oral preventatives so I chose to go with Centragard. It was easy to apply my only complaint was the residue after drying but it brushed right out.

    You liked it! Something went wrong. Please try again later. Report