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Comfortis Chewable Tablets for Dogs 20.1-40 lbs & Cats 12.1 -24.1 lbs, 6 treatments

Prescription Item

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    $96.99

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Description

Comfortis is a chewable medication prescribed by veterinarians for dogs and cats to help treat -- and possibly even prevent -- flea infestations for up to one month. These flavored tablets can be added to your pet's favorite food and only need to be given to your canine companion once a month to help combat fleas.

Uses

Comfortis kills fleas and is indicated for the prevention and treatment of flea infestations, for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.

Possible Side Effects

The most common side effect reported in dogs is vomiting.

Drug & Food Interactions

There are no known drug interactions while using Comfortis.

Precautions

Comfortis chewable tablets are for use in dogs and puppies 14 weeks of age and older. Use with caution in breeding females. Use with caution in dogs with pre-existing epilepsy. The safe use of Comfortis chewable tablets in breeding males has not been evaluated.

  1. Prescribing Information

See all items by Comfortis

  • Item Number
    146121
  • Dosage Measure
    Use according to your veterinarian's instructions.
  • Generic Name
    Spinosad
  • Common Brand Name(s)
    Comfortis, Trifexis
  • For Use With
    Dogs & Cats
  • Brand
    Elanco
  • Breed Size
    Small Breeds, Medium Breeds
  • Product Form
    Chewable Tablet
  • Health Condition
    Fleas
  • Drug Type
    Parasiticide
Ingredients
Ingredients

Spinosad

Instructions
Recommended Dosage

Dose varies based on pet's weight. Use according to your veterinarian's instructions. Comfortis is generally given once a month, but you should always follow your veterinarian's directions. It is recommended to give Comfortis chewable tablets with food.

Storage Instructions

Store at temperatures between 68° - 77°F.

Comfortis is given orally once a month.

FAQ

What are Comfortis Tablets?

They’re beef-flavored, chewable tablets you give to your dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are recommended for monthly use in cats 14 weeks of age or older and 4.1 lbs of body weight or greater and in dogs 14 weeks of age or older and 5 lbs of body weight or greater.

What is Spinosad?

Spinosad is the active ingredient in Comfortis. It belongs to a class of antiparasitics known as spinosyns, which are derived from a naturally-occurring soil microbe. It works by attacking the nervous system of insects, causing the rapid death of adult fleas.

When should treatment with Comfortis begin?

Treatment can begin at any time of the year. Comfortis is most effective when given one month before fleas become active, with continued monthly dosing through the end of the flea season. In areas where fleas are common year-round, monthly treatment with Comfortis chewable tablets should continue through the entire year without interruption. To minimize the likelihood of flea re-infestation, simultaneously treat all animals in your household with an approved flea protection product. Consult your veterinarian for the flea treatment options most appropriate for your area. See also, what should I discuss with my veterinarian regarding Comfortis for my dog or cat?

How quickly will Comfortis (Spinosad) kill fleas?

Spinosad, the active ingredient in Comfortis, began killing fleas in 30 minutes and killed 100% of fleas on dogs and 98% of fleas on cats in just four hours in controlled laboratory studies. Comfortis chewable tablets kill fleas before they can lay eggs.

How long does Comfortis last?

Comfortis has demonstrated full effectiveness for an entire month.

Does seeing fleas on my dog or cat means the treatment isn't working?

Comfortis kills fleas before they can lay eggs when used monthly, according to the label directions. If you see fleas on your dog or cat within a month after your pet receives Comfortis, they are most likely new fleas. Because your pet has been treated with Comfortis, these new fleas will be killed before they can produce eggs that contaminate your home. Continued monthly use of Comfortis can prevent any new flea infestations.

Your pet can experience continued exposure to fleas living in the environment. It’s important to treat all animals in the household with an approved flea product to help control the flea population. Learn more about controlling flea infestations in your home.

Is it safe to give Comfortis (Spinosad) to my dog or cat?

Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Use only for cats and kittens 14 weeks of age or older and 4.1 lbs of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5.0 lbs of body weight or greater. The safe use of Comfortis in breeding, pregnant or lactating cats and dogs has not been evaluated.

My pet has allergies, can he still take Comfortis?

Comfortis contains beef flavoring made from a pork-based protein. If your pet has an allergy to pork, you may need to consider an alternative for flea treatment and prevention. Please discuss these options with your pet's veterinarian. The use of ivermectin at higher than FDA-approved doses at the same time as Comfortis can result in serious side effects.

What side effects might occur with Comfortis?

As with any medication, sometimes side effects occur. See the Comfortis label for complete safety information.

For cats: In some cases, cats vomited after receiving Comfortis. If vomiting occurs within one hour of administration, re-dose with another full dose. Additional adverse reactions observed in studies were lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. See the Comfortis label for complete safety information.

For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness, and disorientation. See the Comfortis label for complete safety information.

How should I give Comfortis (Spinosad) to my pet?

Administer Comfortis with food for maximum effectiveness. Because Comfortis is a flavored tablet, it can be offered just prior to or just after feeding. You can also administer Comfortis as you would other tablet medications. Visit the Dosing & Administration page for more details, or download the Comfortis label. Each box includes reminder stickers for your calendar to help remind you to administer each dose. You can also sign up for monthly text or email reminders.

How much food do I have to give my pet when adminisering the Comfortis Tablet?

In field trials, dog and cat owners were instructed to give the Comfortis tablet with food. However, the quantity of food was not specified and Comfortis was still effective. An option is to give Comfortis immediately before a regularly scheduled meal. For free feeders (dogs or cats who nibble throughout the day), you might take food away at night, administer Comfortis first thing in the morning, then put the food back down.

What id I miss a dose of Comfortis?

Give your pet his or her regular dose immediately, then resume a regular monthly schedule. To help you remember to dose your pet, sign up for monthly email or text message reminders. For complete safety information, view the Comfortis label.

What if I give more than the prescribed amount of Comfortis to my pet?

Contact your veterinarian if you believe your pet has ingested more than the recommended dose of Comfortis. Visit the Dosing & Administration page for more details, or see the Comfortis label for complete safety information.

Should I restrict my pet's activity or contact with my pet after the tablet is consumed?

No. You can continue normal activities and interactions with your pet.

Can other medications be given while my pet is taking Comfortis?

Comfortis is not contraindicated for use with any veterinary drug/product when they are administered at labeled doses. However, while labeled heartworm preventatives are not an issue, you should not use Comfortis concurrently with extra-label doses of ivermectin in dogs and should use caution in cats. Make sure your veterinarian is aware of all products that you intend to administer to your pet. In well-controlled field studies, Comfortis chewable tablets were administered safely in conjunction with other frequently used labeled products, such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, prescription diets, and most generally prescribed medications.

What should I discuss with my veterinarian regarding Comfortis for my dog or cat?

Your veterinarian is your pet's healthcare expert and can make the best medication recommendations. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites. These parasites can cause conditions including flea allergy dermatitis, anemia, and heart disease. Key points of your discussion might include:

  • The best time to start flea treatment in your geographic region.
  • What administration method will work best for your pet.
  • What to do if you miss a dose of Comfortis.
  • What other medications you give your pet.
  • What to do about a severe flea infestation.
  • What steps you can take to prevent a flea re-infestation in your home.

What are Comfortis Tablets?

They�re beef-flavored, chewable tablets you give to your dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are recommended for monthly use in cats 14 weeks of age or older and 4.1 lbs of body weight or greater and in dogs 14 weeks of age or older and 5 lbs of body weight or greater.

What is Spinosad?

Spinosad is the active ingredient in Comfortis. It belongs to a class of antiparasitics known as spinosyns, which are derived from a naturally-occurring soil microbe. It works by attacking the nervous system of insects, causing the rapid death of adult fleas.

When should treatment with Comfortis begin?

Treatment can begin at any time of the year. Comfortis is most effective when given one month before fleas become active, with continued monthly dosing through the end of the flea season. In areas where fleas are common year-round, monthly treatment with Comfortis chewable tablets should continue through the entire year without interruption. To minimize the likelihood of flea re-infestation, simultaneously treat all animals in your household with an approved flea protection product. Consult your veterinarian for the flea treatment options most appropriate for your area. See also, what should I discuss with my veterinarian regarding Comfortis for my dog or cat?

How quickly will Comfortis (Spinosad) kill fleas?

Spinosad, the active ingredient in Comfortis, began killing fleas in 30 minutes and killed 100% of fleas on dogs and 98% of fleas on cats in just four hours in controlled laboratory studies. Comfortis chewable tablets kill fleas before they can lay eggs.

How long does Comfortis last?

Comfortis has demonstrated full effectiveness for an entire month.

Does seeing fleas on my dog or cat means the treatment isn't working?

Comfortis kills fleas before they can lay eggs when used monthly, according to the label directions. If you see fleas on your dog or cat within a month after your pet receives Comfortis, they are most likely new fleas. Because your pet has been treated with Comfortis, these new fleas will be killed before they can produce eggs that contaminate your home. Continued monthly use of Comfortis can prevent any new flea infestations.

Your pet can experience continued exposure to fleas living in the environment. It�s important to treat all animals in the household with an approved flea product to help control the flea population. Learn more about controlling flea infestations in your home.

Is it safe to give Comfortis (Spinosad) to my dog or cat?

Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Use only for cats and kittens 14 weeks of age or older and 4.1 lbs of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5.0 lbs of body weight or greater. The safe use of Comfortis in breeding, pregnant or lactating cats and dogs has not been evaluated.

My pet has allergies, can he still take Comfortis?

Comfortis contains beef flavoring made from a pork-based protein. If your pet has an allergy to pork, you may need to consider an alternative for flea treatment and prevention. Please discuss these options with your pet's veterinarian. The use of ivermectin at higher than FDA-approved doses at the same time as Comfortis can result in serious side effects.

What side effects might occur with Comfortis?

As with any medication, sometimes side effects occur. See the Comfortis label for complete safety information.

For cats: In some cases, cats vomited after receiving Comfortis. If vomiting occurs within one hour of administration, re-dose with another full dose. Additional adverse reactions observed in studies were lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. See the Comfortis label for complete safety information.

For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness, and disorientation. See the Comfortis label for complete safety information.

How should I give Comfortis (Spinosad) to my pet?

Administer Comfortis with food for maximum effectiveness. Because Comfortis is a flavored tablet, it can be offered just prior to or just after feeding. You can also administer Comfortis as you would other tablet medications. Visit the Dosing & Administration page for more details, or download the Comfortis label. Each box includes reminder stickers for your calendar to help remind you to administer each dose. You can also sign up for monthly text or email reminders.

How much food do I have to give my pet when adminisering the Comfortis Tablet?

In field trials, dog and cat owners were instructed to give the Comfortis tablet with food. However, the quantity of food was not specified and Comfortis was still effective. An option is to give Comfortis immediately before a regularly scheduled meal. For free feeders (dogs or cats who nibble throughout the day), you might take food away at night, administer Comfortis first thing in the morning, then put the food back down.

What I miss a dose of Comfortis?

Give your pet his or her regular dose immediately, then resume a regular monthly schedule. To help you remember to dose your pet, sign up for monthly email or text message reminders. For complete safety information, view the Comfortis label.

What if I give more than the prescribed amount of Comfortis to my pet?

Contact your veterinarian if you believe your pet has ingested more than the recommended dose of Comfortis. Visit the Dosing & Administration page for more details, or see the Comfortis label for complete safety information.

Should I restrict my pet's activity or contact with my pet after the tablet is consumed?

No. You can continue normal activities and interactions with your pet.

Can other medications be given while my pet is taking Comfortis?

Comfortis is not contraindicated for use with any veterinary drug/product when they are administered at labeled doses. However, while labeled heartworm preventatives are not an issue, you should not use Comfortis concurrently with extra-label doses of ivermectin in dogs and should use caution in cats. Make sure your veterinarian is aware of all products that you intend to administer to your pet. In well-controlled field studies, Comfortis chewable tablets were administered safely in conjunction with other frequently used labeled products, such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, prescription diets, and most generally prescribed medications.

What should I discuss with my veterinarian regarding Comfortis for my dog or cat?

Your veterinarian is your pet's healthcare expert and can make the best medication recommendations. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites. These parasites can cause conditions including flea allergy dermatitis, anemia, and heart disease. Key points of your discussion might include:

  • The best time to start flea treatment in your geographic region.
  • What administration method will work best for your pet.
  • What to do if you miss a dose of Comfortis.
  • What other medications you give your pet.
  • What to do about a severe flea infestation.
  • What steps you can take to prevent a flea re-infestation in your home.

Customer Reviews

21 Reviews 21 Reviews 4 out of 5 Stars

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81% Recommend

81% of reviewersrecommend this product

4 / 5

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21 Reviews

Showing 1-10 of 21 Reviews

  • 5 out of 5 stars

    Meds for Fleas

    By on

    Bought 2 strengths of Comfortis, as I have multiple kitties different weights. The staff really helped me by calling the Vet's office and getting everything done by phone to expedite the order. I was suddenly faced with fleas and wanted to avoid things getting out of hand. The Customer Service staff got the order to the Chewy Pharmacy Monday afternoon and I received the meds Wednesday. I tried the local Vet's office for the meds, but they don't carry them. Thought of Chewy and they didn't disappoint. The Customer Service staff is always very helpful. Thanks again!

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  • 2 out of 5 stars

    To big for cats!

    By on

    I really prefer using comfortis to topical treatments the past few years we've used topical and recently realized one cat was having an adverse reaction to that so I decided to go back to comfortis. I didn't remember and had NO Idea how big the pills are! The cats would not take the pill, and ate around it in dry food, I crushed it up and tried it in wet food cats still wouldn't touch it! We paid to much and have a big flea problem so I couldn’t give up! At this point I decided to crush the pill into a powder put it in a syringe and mix it with water, and give it to the cats like a liquid, as we have with other pills from the vet. The pills were so big they made so much powder that it wouldn’ I really prefer using comfortis to topical treatments the past few years we've used topical and recently realized one cat was having an adverse reaction to that so I decided to go back to comfortis. I didn't remember and had NO Idea how big the pills are! The cats would not take the pill, and ate around it in dry food, I crushed it up and tried it in wet food cats still wouldn't touch it! We paid to much and have a big flea problem so I couldn’t give up! At this point I decided to crush the pill into a powder put it in a syringe and mix it with water, and give it to the cats like a liquid, as we have with other pills from the vet. The pills were so big they made so much powder that it wouldn’t mix well in the syringe, I ended up having to use more than one syringe to administer the medicine. With this pill I had to fill a syringe 3 times to get it watery enough and to be sure she got enough. My cats are pros at avoiding medicine I lost so much of the pill to crushing getting into the syringe then what the cats spit out and blocked from being put into their mouths as well as one threw up 30 mins later. I am afraid of the effectiveness of the medicine will be lacking on the cats because of how much of the pill was lost while being administered. So far I am seeing a decrease of fleas I am just really hoping they got enough of the medicine, if the fleas don’t clear up I will have to switch to another treatment method because this was for the birds!! The effectiveness of the medicine is not my issue it’s treating the cats. Which not really comfortis fault I just REALLY wish there was a way to treat cats w/ this either in liquid form or a MUCH smaller pill! The pill was about the size of a quarter. I looked at it and said "you've got to be kidding me!?!" I made it work but It was torture. and I received a few battle wounds! I’m sure I am not the only one to have this problem so I am just sharing the information to hopefully help you all out. … more

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  • 5 out of 5 stars

    Best product I've found

    By on

    I have not yet ordered this product online. I have been going through a veterinarian in my town. Anyways, I have been amazed with the results. My dog had horrible skin problems from the fleas. Hair loss, constant scratching and biting, bumps, redness. The comfortis got rid of the fleas which has improved her skin problems and hair loss. The only thing that is wrong with it is the strong horrible smell. My dog didn't want anything to do with it. But I was able to hide it in some food(not dog food they eat around it). Putting peanut butter on it the first couple of times worked, but after that she wouldn't eat it. For me, I get a burrito from Taco Bell and give her the end of it with the pill in I have not yet ordered this product online. I have been going through a veterinarian in my town. Anyways, I have been amazed with the results. My dog had horrible skin problems from the fleas. Hair loss, constant scratching and biting, bumps, redness. The comfortis got rid of the fleas which has improved her skin problems and hair loss. The only thing that is wrong with it is the strong horrible smell. My dog didn't want anything to do with it. But I was able to hide it in some food(not dog food they eat around it). Putting peanut butter on it the first couple of times worked, but after that she wouldn't eat it. For me, I get a burrito from Taco Bell and give her the end of it with the pill in it. … more

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  • 5 out of 5 stars

    Highly recommend

    By on

    I have been struggling to keep my cat flea free with other treatments, namely Seresto collars, Adams Plus flea and tick shampoo, and a flea comb. I gave my cat Comfortis two days ago with his meal at night and by morning, my bed (where he sleeps) was covered with about 30 dead fleas! I'd never been so happy to see so many fleas. I highly recommend!

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  • 5 out of 5 stars

    best protection for cats!

    By on

    My cat, Andy, can NOT use topical flea and tick protection due to a severe skin sensitivity. So when we were faced with a HUGE flea infestation I was at a loss. I used a high end flea shampoo then a Sereto collar with no avail. I was vacuuming morning and nigh for weeks, paired with home sprays. I knew an exterminator could treat my home but not poor Andy. I finally called my vet after a month or so and she suggested Comfortis. I bought it on Chewy and the pill combined with my intensive house cleaning, Andy and our home are finally flea free! The pill was big but after breaking it up Andy had no issues! I plan on using Comfortis for my puppy when she becomes of age and weight! 100% recommend My cat, Andy, can NOT use topical flea and tick protection due to a severe skin sensitivity. So when we were faced with a HUGE flea infestation I was at a loss. I used a high end flea shampoo then a Sereto collar with no avail. I was vacuuming morning and nigh for weeks, paired with home sprays. I knew an exterminator could treat my home but not poor Andy. I finally called my vet after a month or so and she suggested Comfortis. I bought it on Chewy and the pill combined with my intensive house cleaning, Andy and our home are finally flea free! The pill was big but after breaking it up Andy had no issues! I plan on using Comfortis for my puppy when she becomes of age and weight! 100% recommend! … more

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  • 1 out of 5 stars

    Cats hate medication

    By on

    Both my cats refuse to eat there food when I put the pill in. Broken crushed or water down to liquid with food. I waste food and money.. but topicala don't work either.. ugh someone make this so cats like it .

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  • 5 out of 5 stars

    Lil' Baby is doing so much better with Comfortis

    By on

    My cat, Lil' Baby, is very allergic to fleas. Nothing was working for her so I asked the Vet what I could do. She suggested Comfortis as a last resort. I got some for both her, and her brother (Mr. Titan). Mr. Titan hated it and wouldn't take it any way we tried. I put Lil' Babies in some milk and she drank it all. She was losing all her fur, from scratching, from her waist down. After a week of taking the Comfortis, she started to groom herself again and stopped scratching herself. Now, a month later, she's still doing good and her fur has grown almost completely back in. It's steep on the price but well worth it to see her getting well. She's almost 15 and very frail but more ambulant My cat, Lil' Baby, is very allergic to fleas. Nothing was working for her so I asked the Vet what I could do. She suggested Comfortis as a last resort. I got some for both her, and her brother (Mr. Titan). Mr. Titan hated it and wouldn't take it any way we tried. I put Lil' Babies in some milk and she drank it all. She was losing all her fur, from scratching, from her waist down. After a week of taking the Comfortis, she started to groom herself again and stopped scratching herself. Now, a month later, she's still doing good and her fur has grown almost completely back in. It's steep on the price but well worth it to see her getting well. She's almost 15 and very frail but more ambulant and "talkative" than she was. I will continue giving this to her. My vet said she doesn't think she has anymore because no one was buying it and she didn't re-order any. She's checking. If she doesn't, I'm definitely purchasing from chewy.com. … more

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  • 5 out of 5 stars

    so far so good

    By on

    Chewy contacted my vet for the prescription and the item was shipped the next day, very fast service. This is the first time that I have used this product. The pills are easy to crush up and mix into my cat's soft food. So far it seems to be working. He is not scratching as much and his fur seems to be growing back.

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  • 5 out of 5 stars

    Cat allergic to fleas and everything else

    By on

    Our cat has super sensitive skin and chews it's hair out. We tried multiple flea preventives which resulted in a nearly bald cat. Our vet had a sample of Comfortis to try. It worked. It's the only preventive we can use. Would recommend

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  • 5 out of 5 stars

    Great flea control

    By on

    My cats hated the topical flea meds- they burned when applied. My cat would be mad @ me for 2 weeks. Now with Comfortis the cats get their meds & no pain

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