Comfortis Chewable Tablets for Dogs, 40.1-60 lbs (Blue Box), slide 1 of 1

Comfortis Chewable Tablets for Dogs, 40.1-60 lbs, 6 treatments (Blue Box)

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Description

Comfortis is a chewable medication prescribed by veterinarians for dogs and cats to help treat -- and possibly even prevent -- flea infestations for up to one month. These flavored tablets can be added to your pet's favorite food and only need to be given to your canine companion once a month to help combat fleas.

Uses

Comfortis kills fleas and is indicated for the prevention and treatment of flea infestations, for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.

Possible Side Effects

The most common side effect reported in dogs is vomiting.

Drug & Food Interactions

There are no known drug interactions while using Comfortis.

Precautions

Comfortis chewable tablets are for use in dogs and puppies 14 weeks of age and older. Use with caution in breeding females. Use with caution in dogs with pre-existing epilepsy. The safe use of Comfortis chewable tablets in breeding males has not been evaluated.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
PinkDogs 5-10 lbs / Cats 4.1-6 lbs140 mg SpinosadGive orally once a month✓-Click Here
OrangeDogs 10.1-20 lbs / Cats 6.1-12 lbs270 mg SpinosadGive orally once a month✓-Click Here
GreenDogs 20.1-40 lbs / Cats 12.1-24 lbs560 mg SpinosadGive orally once a month✓-Click Here
BlueDogs 40.1-60 lbs810 mg SpinosadGive orally once a month✓-Click Here
BrownDogs 60.1-120 lbs1620 mg SpinosadGive orally once a month✓-Click Here
  1. Prescribing Information

See all items by Comfortis

  • Item Number
    146123
  • Generic Name
    Spinosad
  • Common Brand Name(s)
    Comfortis, Trifexis
  • For Use With
    Dogs
  • Administration Form
    Oral
  • Brand
    Elanco
  • Lifestage
    Adult, Senior
  • Breed Size
    Medium Breeds, Large Breeds
  • Product Form
    Chewable Tablet
  • Strength
    810 mg Spinosad
  • Health Condition
    Fleas
  • Drug Type
    Parasiticide
Ingredients
Ingredients

810 mg Spinosad.

Instructions
Recommended Dosage

Dose varies based on pet's weight. Use according to your veterinarian's instructions. Comfortis is generally given once a month, but you should always follow your veterinarian's directions. It is recommended to give Comfortis chewable tablets with food.

Storage Instructions

Store at temperatures between 68° - 77°F.

FAQ

What are Comfortis (Spinosad) Tablets?

They’re beef-flavored, chewable tablets you give to your dog to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are recommended for monthly use in dogs 14 weeks of age or older and 5 lbs of body weight or greater.

What is Spinosad?

Spinosad is the active ingredient in Comfortis. It belongs to a class of antiparasitics known as spinosyns, which are derived from a naturally-occurring soil microbe. It works by attacking the nervous system of insects, causing the rapid death of adult fleas.

When should treatment with Comfortis begin?

Treatment can begin at any time of the year. Comfortis is most effective when given one month before fleas become active, with continued monthly dosing through the end of the flea season. In areas where fleas are common year-round, monthly treatment with Comfortis chewable tablets should continue through the entire year without interruption. To minimize the likelihood of flea re-infestation, simultaneously treat all animals in your household with an approved flea protection product. Consult your veterinarian for the flea treatment options most appropriate for your area. See also, what should I discuss with my veterinarian regarding Comfortis for my dog?

How quickly will Comfortis (Spinosad) kill fleas?

Spinosad, the active ingredient in Comfortis, began killing fleas in 30 minutes and killed 100% of fleas on dogs in just four hours in controlled laboratory studies. Comfortis chewable tablets kill fleas before they can lay eggs.

How long does Comfortis last?

Comfortis has demonstrated full effectiveness for an entire month.

Does seeing fleas on my dog mean the treatment isn't working?

Comfortis kills fleas before they can lay eggs when used monthly, according to the label directions. If you see fleas on your dog within a month after your pet receives Comfortis, they are most likely new fleas. Because your pet has been treated with Comfortis, these new fleas will be killed before they can produce eggs that contaminate your home. Continued monthly use of Comfortis can prevent any new flea infestations.

Your pet can experience continued exposure to fleas living in the environment. It’s important to treat all animals in the household with an approved flea product to help control the flea population. Learn more about controlling flea infestations in your home.

Is it safe to give Comfortis (Spinosad) to my dog?

Comfortis has demonstrated to be safe in healthy dogs when used according to label directions. Use only for dogs and puppies 14 weeks of age and older and 5 lbs of body weight or greater. The safe use of Comfortis in breeding, pregnant or lactating dogs has not been evaluated.

My pet has allergies, can he still take Comfortis?

Comfortis contains beef flavoring made from a pork-based protein. If your pet has an allergy to pork, you may need to consider an alternative for flea treatment and prevention. Please discuss these options with your pet's veterinarian. The use of ivermectin at higher than FDA-approved doses at the same time as Comfortis can result in serious side effects.

What side effects might occur with Comfortis?

As with any medication, sometimes side effects occur. See the Comfortis label for complete safety information.

The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. See the Comfortis label for complete safety information.

How should I give Comfortis (Spinosad) to my pet?

Administer Comfortis with food for maximum effectiveness. Because Comfortis is a flavored tablet, it can be offered just prior to or just after feeding. You can also administer Comfortis as you would other tablet medications. Visit the Dosing & Administration page for more details, or download the Comfortis label. Each box includes reminder stickers for your calendar to help remind you to administer each dose. You can also sign up for monthly text or email reminders.

How much food do I have to give my pet when administering the Comfortis Tablet?

In field trials, dog owners were instructed to give the Comfortis tablet with food. However, the quantity of food was not specified and Comfortis was still effective. An option is to give Comfortis immediately before a regularly scheduled meal. For free feeders (dogs who nibble throughout the day), you might take food away at night, administer Comfortis first thing in the morning, then put the food back down.

What if I miss a dose of Comfortis?

Give your pet his or her regular dose immediately, then resume a regular monthly schedule. To help you remember to dose your pet, sign up for monthly email or text messaging reminders. For complete safety information, view the Comfortis label.

What if I give more than the prescribed amount of Comfortis to my pet?

Contact your veterinarian if you believe your pet has ingested more than the recommended dose of Comfortis. Visit the Dosing & Administration page for more details, or see the Comfortis label for complete safety information.

Should I restrict my pet's activity or contact with my pet after the tablet is consumed?

No. You can continue normal activities and interactions with your pet.

Can other medications be given while my pet is taking Comfortis?

Comfortis is not contraindicated for use with any veterinary drug/product when they are administered at labeled doses. However, while labeled heartworm preventatives are not an issue, you should not use Comfortis concurrently with extra-label doses of ivermectin in dogs. Make sure your veterinarian is aware of all products that you intend to administer to your pet. In well-controlled field studies, Comfortis chewable tablets were administered safely in conjunction with other frequently used labeled products, such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, prescription diets, and most generally prescribed medications.

What should I discuss with my veterinarian regarding Comfortisfor my dog?

Your veterinarian is your pet's healthcare expert and can make the best medication recommendations. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites. These parasites can cause conditions including flea allergy dermatitis, anemia, and heart disease. Key points of your discussion might include:

  • The best time to start flea treatment in your geographic region.
  • What administration method will work best for your pet.
  • What to do if you miss a dose of Comfortis.
  • What other medications you give your pet.
  • What to do about a severe flea infestation.
  • What steps you can take to prevent a flea re-infestation in your home.
Rating: 4.8 of 5 stars 14 Reviews 14 Reviews 4.9 out of 5 Stars

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Rating: 4.8 of 5 stars 4.9 / 5

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14 Reviews

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  • 5 out of 5 stars

    My Great Dane approved!

    By on

    I tried several topical flea/tick preventatives, but on 175# dog, they just didn’t cut it. So, I asked my vet. He recommended Comfortis, so I paid for it and my vet gave it to my Dooley before we left the office. By the time we got home, about an hour later, I could tell it was working. At that time, I had a huge yard, which was surrounded on 3 sides by woods, so ticks were also an issue. After him taking Comfortis, I didn’t see any ticks on him over the next couple of weeks either, so I asked my vet what was going on since this product is only supposed to repel fleas. He explained that it does work for ticks too, but for a manufacturer to make that claim, they have to go through a more rigorous I tried several topical flea/tick preventatives, but on 175# dog, they just didn’t cut it. So, I asked my vet. He recommended Comfortis, so I paid for it and my vet gave it to my Dooley before we left the office. By the time we got home, about an hour later, I could tell it was working. At that time, I had a huge yard, which was surrounded on 3 sides by woods, so ticks were also an issue. After him taking Comfortis, I didn’t see any ticks on him over the next couple of weeks either, so I asked my vet what was going on since this product is only supposed to repel fleas. He explained that it does work for ticks too, but for a manufacturer to make that claim, they have to go through a more rigorous testing process. Also, one dose lasted my Dane all summer long. I didn’t have to give it again. I’ve continued to use this for my American Bulldogs, and one dose lasts them the whole flea and tick season as well. I realize not everyone may have these same results, but even if this product didn’t over deliver on its promises, I would still highly recommend!! … more

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  • 4 out of 5 stars

    Flea Prevention

    By on

    I have a dog with a severe flea allergy and an MDR1 status that requires care with medications. Comfortis was recommended for him 3 years ago by a veterinary dermatologist. It has done the job well, preventing further skin outbreaks. However, the odor from the tablets is awful, and strong! My other dog will not take this medication, even when hidden in food, and I can't force it down his throat. Fortunately, the dog that needs it tolerates it. So my recommendation comes with a qualification about the stench from this product.

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  • 5 out of 5 stars

    Fast shipping

    By on

    Fair price on product and no fleas so my pup can rest,but even better was the fast free shipping. Even in a pandemic and requiring vet approval it arrived FAST! THANKS Chewy!!!!!!

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  • 5 out of 5 stars

    Works great

    By on

    seems to help my dogs during the summer more than regular flea control

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  • 5 out of 5 stars

    It’s excellent

    By on

    Been using Comfortis for couple of years, does great job keeping the fleas and ticks away. First time using Chewy RX, was very easy to put in vet info, fast turnaround.!

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  • 5 out of 5 stars

    Good Fast Service as Usual

    By on

    I recently moved out of CA for political reasons and did not have the opportunity to utilize Chewy's services. My order arrive in 2 days, "as usual" Thanks Chewy P.S. My dog has been on Comfortis for 5 years, no fleas at all!!

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  • 4 out of 5 stars

    Comfortis Chewable

    By on

    One of the few flea medication that my dogs have success with. However one of them will not take the chewable tablet voluntarily.

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  • 5 out of 5 stars

    Great and effective.

    By on

    Great and effective product, have been using for years.

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  • 5 out of 5 stars

    A flea medication that never fails!

    By on

    We have a sharpei that has very sensitive skin and also a allergy to fleas. We can’t use topical flea medication because it causes blisters and hair loss. Do to this being orally administered she gets the protection without the negative reactions. We have been using comfortis on her for the last 8 years. Vets local to us have slowly started switching to new medications and it’s been hard to find. Thankfully we are still able to get comfortis from Chewy so we never have to worry about or girl getting fleas and we don’t have to worry about trying something new and her getting a reaction.

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  • 5 out of 5 stars

    Flea medication

    By on

    Does great with dogs that have flea allergies my dog can’t go without it.

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