Diphenhydramine HCl (Generic) Capsules, slide 1 of 1

Diphenhydramine HCl (Generic) Capsules

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In stock
Strength: 25-mg
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Count: 1 capsule

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Diphenhydramine HCI, commonly known as Benadryl is an antihistamine prescribed to help relieve allergy symptoms. Some of these symptoms may include coughing and itching caused by insect bites, pollen, house dust along with other allergy triggers. This medication may also help control vomiting and motion sickness and may be prescribed as a mild sedative to help treat muscle tremors caused by toxins or other medications. Customers may receive this drug under the names Benadryl (Warner Lambert), Histacalm (Virbac).

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Temporarily relieves symptoms due to upper respiratory allergies, such as itching skin, sneezing and itchy, watery eyes.

Possible Side Effects

Side effects of diphenhydramine include drowsiness, dry mouth and urinary retention. Vomiting and diarrhea have also been reported in rare cases.

Drug & Food Interactions

Always tell your vet about other medications the pet is taking. The capsule should not be mixed or dissolved in food.


Do not use this medication in those allergic to it or other antihistamines. Do not use in those with glaucoma, prostate disease, urinary obstruction and high blood pressure. Do not use in pregnant or nursing animals. Use with caution when given with other CNS (central nervous system)-depressant drugs, such as tranquilizers or barbiturates. Always tell your vet what other medications the pet is taking.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Chewy Pharmacy vial.

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  1. Prescribing Information

See all items by Diphenhydramine

  • Item Number
  • Common Brand Name(s)
  • Generic Name
    Diphenhydramine Hydrochloride
  • For Use With
    Dogs & Cats
  • Administration Form
  • Lifestage
  • Product Form
  • Health Condition
    Motion Sickness, Anxiety, Allergies
  • Drug Type


Recommended Dosage

Use as directed by your veterinarian.

Storage Instructions

Store at temperatures between 68° - 77°F.


What is Diphenhydramine?

An antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions.

What are the benefits of Diphenhydramine?

Relieves coughing, allergy symptoms and itching caused by insect bites. Can also be used as a sedative to treat motion sickness and anxiety.

How is this medication given?

Use as directed by your veterinarian.

How does this medication work?

As an antihistamine, Diphenhydramine counteracts the effect of histamine, which causes symptoms like itching and sneezing.

Rating: 3.6 of 5 stars 3 Reviews 3 Reviews 3.7 out of 5 Stars

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67% Recommend

67% of reviewersrecommend this product

Rating: 3.6 of 5 stars 3.7 / 5

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3 Reviews

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  • 5 out of 5 stars

    Perfect for Motion Sickness

    By Erik on May 24, 2021

    My doctor suggested that I use Benadryl for my Golden suffering from severe motion sickness in the car. Since I started using it, my dog's sickness is virtually gone.

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  • 1 out of 5 stars

    Does not work if your animals have heavy allergies

    By Sally on May 14, 2021

    I wouldn’t suggest getting an over the counter allergy medication if your animal has bad allergies. This is a script not worth having in my situation.

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  • 5 out of 5 stars

    Itchy GSD

    By Dogmomma94 on Mar 28, 2021 top1000Contributor

    We use these twice a day to keep his itchy skin in check. Helps mostly and a bit safer than those apoquel pills or the cytopoint injection. We just put them in a Pill assist from royal canin.

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