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Advantage II Flea Treatment for Small Dogs 3-10 lbs

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Advantage II Flea Treatment for Dogs 10 lbs and Under is a convenient monthly topical flea treatment for dogs and puppies 7 weeks of age and older. Advantage II for dogs contains an (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your dog to die. One convenient application of Advantage II for dogs keeps working for 1 month.

Key Benefits

  • Kills all flea life stages including flea eggs, larvae, pupae, and adult fleas
  • Kills fleas within 12 hours of initial application
  • Once a month topical treatment for fleas and lice
  • Works through contact, so fleas don’t have to bite to die. Provides waterproof protection
  • For use only on dogs and puppies 7 weeks and older and weighing 3-10 lbs.


For use only on dogs and puppies 7 weeks and older and weighing 3 to 10 pounds. DO NOT USE ON CATS. Keep out of reach of children. If your dog is on medication, consult your veterinarian before using this or any other product. Do not get this product in your dog's eyes or allow your dog to ingest this product.

Active Ingredients

  • Imidacloprid 9.10%
  • Pyriproxyfen 0.46%

See all items by Advantage II

  • Item Number
  • Brand
  • Breed Size
  • Lifestage
    Adult, Puppy


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet‘s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dogs should be standing for easy application. Apply the entire contents of the tube evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog‘s eyes or allow your dog to ingest this product.
  • Discard empty tube.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage II.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II adds larvicidal and ovicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.


Dog Weight Advantage II
3 to 10 pounds Small Dog
11 to 20 pounds Medium Dog
21 to 55 pounds Large Dog
over 55 pounds Extra Large Dog

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Customer Reviews

Advantage II Flea Treatment for Small Dogs 3-10 lbs is rated 4.6 out of 5 by 63.
Rated 5 out of 5 by from Fleas dying Gave on a Wednesday, fleas dying by next day. Great product!
Date published: 2017-01-16
Rated 5 out of 5 by from It works! My dear sweet toy poodle who has not seen one single chemical in his 10 years on this earth is still alive. I don't vax and he is raw fed. We have managed the fleas with natural topicals and DE topical and in his food but this year has been horrendous. He was MISERABLE. Calm Coat products would help a little but.... So I finally gave in and applied this yesterday and almost immediately he was able to relax and so far he has been so much better. He'll still scratch but only for a few minutes. It has truly been a miracle. I'd also like to thank the seller profusely for such quick shipping. And also a great price and reasonable shipping. You beat Amazon on this one :o) And sorry folks but we are praying for an early frost....just enough to kill the blasted fleas and still have a nice autumn.
Date published: 2016-09-24
Rated 5 out of 5 by from AWESOME This is my go to flea meds for my 6 pound Chihuahua. She came from the humane society so she did have fleas when I got her home. This works well for her she has no reaction to it and it seems to do the job. I have tried the cheaper meds and they do not work as well. This is definitely worth it!!
Date published: 2017-02-19
Rated 5 out of 5 by from Good effective product for the money Good effective product for the money. Brand works well for both my dog & cat.
Date published: 2017-02-25
Rated 5 out of 5 by from Very happy with product and prompt delivery The product came as expected. I actually had to call immediately after I placed the order in order to confirm when I should expect it. The customer service representative was excellent and told me that it would probably come overnight delivery. My order came the very next day.
Date published: 2017-01-11
Rated 5 out of 5 by from Reliable! When it comes to flee meds, there is not time for guessing if a product works. Advantage II immediately works! Pets are happy again. Humans are not experiencing flee bites. House goes back to normal. This product is reliable and works.
Date published: 2017-02-07
Rated 5 out of 5 by from Recommended by our Vet. We just got a new puppy and asked our Vet for his opinion of Advantage ll. We had been using Front Line for 10 years+. The Vet said that Advantage ll is the best of all these types of products so we took his recommendation.
Date published: 2017-01-10
Rated 5 out of 5 by from Easy To Apply This flea med is easy to apply and quick so no long process to scare the dogs. We have no fleas so it is working. Also, no side effects that we noticed.
Date published: 2017-02-03
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