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Advantage II Flea Treatment for Dogs 21-55 lbs

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Advantage II Flea Treatment for Dogs 21-55 lbs is a convenient monthly topical flea treatment for dogs and puppies 7 weeks of age and older. Advantage II for dogs contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your dog to die. One convenient application of Advantage II for dogs keeps working for 1 month.

Key Benefits

  • Kills all flea life stages including flea eggs, larvae, pupae, and adult fleas
  • Kills fleas within 12 hours of initial application
  • Once a month topical treatment for fleas and lice
  • Works through contact, so fleas don’t have to bite to die. Provides waterproof protection
  • For use only on dogs and puppies 7 weeks and older and weighing 21-55 lbs.


DO NOT USE ON CATS. Do not apply to puppies or dogs weighing less than 3 lbs. Do not get this product in your dog's eyes or allow your dog to ingest this product. ALWAYS read the entire product label prior to use.

Active Ingredients

  • 9.1% Imidacloprid
  • 0.46% Pyripoxyfen

See all items by Advantage II

  • Item Number
  • Brand
  • Breed Size
  • Lifestage
    Puppy, Adult
  • Made in
    United States


Once-a-month topical treatment for the prevention and treatment of flea and lice infestations on dogs and puppies 7 weeks and older. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail.

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Customer Reviews

Rated 4.7 out of 5 by 58 reviewers.
Rated 5 out of 5 by Working in Ga Fleas not standing a chance with this Advantage ll here in atlanta ,ga. Its hard to keeo it from dripping down the dog's side though, not sure how to avoid that. October 28, 2016
Rated 5 out of 5 by It works! Autoship is very convenient and this product really works! October 27, 2016
Rated 5 out of 5 by this is the best flea treatment Shipping was so fast... Will only order from you guys from now on October 23, 2016
Rated 5 out of 5 by This really works. Previously tried Kirkland brand( from Costco) flea treatment, and had no luck what so ever trying to get rid of the fleas. Advantage II really did the trick, we are so happy now, and so is the dog. Will be back for more in about six months. September 24, 2016
Rated 5 out of 5 by Flea med They have no more fleas and itch free. . I love this product..... There şo much happier.... September 18, 2016
Rated 5 out of 5 by No Fleas I've used this product since it came out and have been very happy to have no fleas. (So have my dogs!) It is the product I always recommend to friends. September 17, 2016
Rated 5 out of 5 by Works great !! I tried FrontLine for three months and it didn't work at all. Fleas were still all over my pug. One day after the first treatment of Advantage, the fleas were gone and the sweet little pug was as happy as can be. Thanks Advantage !!! September 12, 2016
Rated 4 out of 5 by Advantage I normally use another brand, but decided to try this one. So far it seems to be effective. I will say its been a very very bad year for fleas due to the hot humid weather. September 12, 2016
  • 2016-10-31 T06:31:38.047-05:00
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