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Advantage II Flea Treatment for Extra Large Dogs Over 55 lbs

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Advantage II Flea Treatment for Dogs Over 55 lbs is a convenient monthly topical flea treatment for dogs and puppies 7 weeks of age and older. Advantage II for dogs contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your dog to die. One convenient application of Advantage II for dogs keeps working for 1 month.

Key Benefits

  • Kills all flea life stages including flea eggs, larvae, pupae, and adult fleas
  • Kills fleas within 12 hours of initial application
  • Once a month topical treatment for fleas and lice
  • Works through contact, so fleas don’t have to bite to die. Provides waterproof protection
  • For use only on dogs and puppies 7 weeks and older and weighing over 55 lbs.


For use only on dogs and puppies 7 weeks and older and weighing 55 lbs and over. DO NOT USE ON CATS. Keep out of reach of children. If your dog is on medication, consult your veterinarian before using this or any other product. Do not get this product in your dog's eyes or allow your dog to ingest this product.

Active Ingredients

  • Imidacloprid 9.10%
  • Pyriproxyfen 0.46%

See all items by Advantage II

  • Item Number
  • Brand
  • Breed Size
  • Lifestage
    Puppy, Adult
  • Made in
    United States


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position facing away from you and your pet‘s face and eyes. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dogs should be standing for easy application. Apply the entire contents of the tube evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog‘s eyes or allow your dog to ingest this product.
  • Discard empty tube.
  • Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

What is the difference between Advantage Topical Solution and Advantage II?

We have added an insect growth regulator, pyriproxyfen, to Advantage II.

What is an insect growth regulator (IGR)?

An IGR, such as pyriproxyfen, inhibits the development of flea eggs. It also offers additional larvicidal properties when compared with imidacloprid alone.

How does pyriproxyfen work?

Pyriproxyfen mimics the juvenile growth hormone of fleas. This hormone prevents immature flea stages from molting into the next stage of the life cycle and keeps them from developing into adult fleas.

Why is it important to use a product with an IGR?

With an IGR as part of your flea control, the flea life cycle is disrupted at multiple stages through different active ingredients and modes of action. This is often referred to as integrated flea control (IFC). The addition of an IGR to Advantage II adds larvicidal and ovicidal properties to target flea infestations and kill all flea life stages.

Is Advantage II waterproof?

Yes, there is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

  1. Advantage II Use & Care Instructions


Dog Weight Advantage II
3 - 10 lbs Small Dog
11 - 20 lbs Medium Dog
21 - 55 lbs Large Dog
Over 55 lbs Extra Large Dog

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Customer Reviews

169 reviews 169 Reviews 4.7 out of 5 Stars

96% Recommend

96% of reviewersrecommend this product

4.7 / 5
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  • Worked for my Lab

    By on

    I really don't like using chemicals and will go the all natural route if I can. When my Labrador got fleas, I tried very hard to get rid of them without using flea drops. After several failed treatments and attempts (some would get rid of the fleas but then they come right back just as bad) and doing a whole lot of research and consulting with an exterminator, I chose the advantage II. Very shortly afterward the fleas started dropping off. My dog had also developed a rash from the flea bites and the rash started getting better very quickly. The flea issue resolved and my sweet dog did not experience any side effects. Now I wont use anything else for flea control on my dog.

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  • I switched from Frontline Gold to this.......

    By on

    Here in TN we have a major flea problem. I had used Frontline Gold last time with little success, so this time I ordered Advantage II for my pitbull. It has worked great for him. I'm happy cos the fleas actually makes him depressed. Sounds weird, but it's true! So, when your pitbull's happy, everyone's happy! I think different products work differently on individual animals. I would recommend this product to others.

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  • Work so well

    By on

    Ordered this item on July 3rd and even with the holiday I still received it on the 5th. My 140lb great dane already had fleas but with a day or 2 of using just the one treatment I didn't see any more fleas, on him or in my house. I was skeptical using something with a broad spectrum for large dogs (over 55lbs) when he weighs more than double that but it worked perfectly. I would recommend this to anyone and everyone!

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  • Awesome for flea allergies

    By on

    I was purchasing this item thru my dogs' veterinarian at a much higher price & only 4 tubes per box - my pets have seen this vet for many many years but he is retiring. I was so happy to find Chewy carried the product & more product lower price. Two of my dogs have extreme flea allergies & this product is the only one that's solved our problem.

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    By on

    My golden retriever, Buckley, are sold on Advantage II. Thirty days ago, I bought Frontline Plus, applied it to my dogs coat, anti was like it had no effect. I returned the unused portion of that product to the pet store, bought Advantage II, and my dog was completely relaxed, and free of any further flea irritation within 20 minutes. That's a sign of a good product.

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  • Chewy.com rates high with us

    By on

    This company is easy to work with by phone or email . The products are cost effective . Shipment is reliable and shipment notification let's us know when to expect it . My older dog has trimmed down and become more energetic .

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  • Definitely works

    By on

    Used this product on both my cat and dog 1 week ago after giving them flea baths. There's still a few fleas in the house, but there are none on the animals. I am sure that we will soon be completely done with the fleas if we keep using this.

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  • Chewy's the Bomb!!

    By on

    This was included in my third Auto-Ship order from Chewy. It is just one product of those I routinely purchase for my dog. It, like all orders to date, arrived just one to two days after Chewy emailed me of its shipment, and thoroughly met my high standards for quality and shelf life! Prices, service, & quality cannot be beat!! Thanks, Chewy! I'm SO glad I found you!!!

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  • product review

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    First time I have used "Chewy". Not the first time I have used this product. Extremely competitive pricing with easy, efficient and prompt service. Definitely will be ordering again.

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  • Best stuff around

    By on

    I had a major flea problem on dogs and in house last summer. I tried everything and nothing worked. I put this on dog and within 2 weeks not only were the dogs flea free the house was too! I haven't used anything else since. Chewy has the best price too

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