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Advantage II Flea Treatment for Dogs Over 55 lbs

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Advantage II Flea Treatment for Dogs Over 55 lbs is a convenient monthly topical flea treatment for dogs and puppies 7 weeks of age and older. Advantage II for dogs contains an adulticide (imidacloprid) and an insect growth regulator (pyriproxyfen) to kill all life stages of fleas. Furthermore, it kills fleas through contact, so they don’t have to bite your dog to die. One convenient application of Advantage II for dogs keeps working for 1 month.

Key Benefits

  • Kills all flea life stages including flea eggs, larvae, pupae, and adult fleas
  • Kills fleas within 12 hours of initial application
  • Once a month topical treatment for fleas and lice
  • Works through contact, so fleas don’t have to bite to die. Provides waterproof protection
  • For use only on dogs and puppies 7 weeks and older and weighing over 55 lbs.


DO NOT USE ON CATS. Do not apply to puppies or dogs weighing less than 3 lbs. Do not get this product in your dog's eyes or allow your dog to ingest this product. ALWAYS read the entire product label prior to use.

Active Ingredients

  • 9.1% Imidacloprid
  • 0.46% Pyripoxyfen

See all items by Advantage II

  • Item Number
  • Brand
  • Breed Size
  • Lifestage
    Puppy, Adult
  • Made in
    United States


  • Use only on dogs. Do not use on other animals.
  • Remove one applicator tube from the package.
  • Hold applicator tube in an upright position. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • For Dogs 10 lbs and under & 11-20 lbs: The dog should be standing for easy application. Part the hair on the dog's back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your dog's eyes or mouth.

  • For Dogs 21-55 lbs & Over 55 lbs: The dog should be standing for easy application. The entire contents of the Advantage II tube should be applied evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your pet's eyes or mouth.

  • Do not reuse empty container. Wrap container and put in trash.

  • In case of a severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly schedule.

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Customer Reviews

Advantage II Flea Treatment for Dogs Over 55 lbs is rated 4.8 out of 5 by 111.
Rated 3 out of 5 by from At least it is working This Summer brought with it fleas like I've never seen before, truelly grotesque. After THREE other brands failed to get the problem in check, this seems to be (kind of) working. The fleas aren't dying at the advertised rate, the first day was particularly terrible as the spasming fleas where ravaging anything they could bite. It cut down their numbers, but there are still a lot present. The product states a second dose can be applied a week later for severe infestations, hopfully it kills off the rest. It worked far better than another popular monthly topical (which did litterally nothing). It has reduced our problem but there are still a lot of fleas. Everyone in our area is complaining about the same problem (even households without pets are having severe flea problems here for some reason...as I said, it's been an inordinately terrible season!). I will leave a follow up review if the level of fleas continues to sink (or perish the thought, becomes more severe in spite of it).
Date published: 2016-09-29
Rated 5 out of 5 by from Safe, and quite effective. Flea treatment is very important in most climates, even during the winter months. The apartment upstairs had a very bad flea infestation. They were required to move out. Great! But the wrap around porch ended up with so many hungry fleas on it that the fleas would cover my socks and shoes. Advantage II really helped me avoid a huge problem.
Date published: 2017-01-04
Rated 5 out of 5 by from Efficient and Exceeded Expectations First purchase on chewy.com and have been very pleased. Price was 40%off and perfect alternative to paying double at vet. Dog had an allergic reaction to a flea bite so ordered meds. Arrived in 2 days, topical application, and within hours she was feeling much better. Will order again and look for other deals from chewy.com. just wish they participated on ebates.
Date published: 2016-12-31
Rated 5 out of 5 by from Love it for all my pets One of my dogs gets seizures from all other topical flee treatment and he is highly alergic to flees. My other dog gets itchy from other topical treatments. This stuff is great no problems with anything and best of all it works great. No more flees.
Date published: 2016-11-30
Rated 4 out of 5 by from Works better than most. All flea products eventually don't work in the long run as fleas become accustomed to it. However Advantage II is better than most and it works great on my 70lb Standard Poodle.
Date published: 2016-12-14
Rated 5 out of 5 by from This works! I was using Frontline plus with no results, but I tried this product and the fleas were gone in a day! I will definitely buy this again
Date published: 2017-01-01
Rated 5 out of 5 by from Great product Took care of the fleas on my two dogs in three days
Date published: 2016-11-29
Rated 5 out of 5 by from Advantage economy tip We buy the largest dog size online and use it in smaller doses for our multiple cats. Saves a bundle.
Date published: 2016-10-16
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