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Bio Spot Active Care Flea & Tick Spot On for Dogs, 31-60 lbs, 3 treatments

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Bio Spot Active Care Flea & Tick Spot On for Dogs ensures continuing long-term protection for your pet. Bio Spot Active Care topical gel kills adult fleas and ticks and contains an insect growth regulator to kill flea eggs and larvae for up to 30 days. Included applicator helps keep the liquid off your hands, makes it easier to part your dog's fur, gets liquid down to your dog's skin and is easy to load and apply.

Key Benefits

  • Includes Bio Spot Smart Shield Applicator which helps keep the liquid off your hands, makes it easier to part your dog's fur, and gets liquid down to your dog's skin
  • For use on dogs and puppies 12 weeks of age or older
  • Kills fleas, flea eggs, flea larvae and deer ticks for up to 1 month. Also kills mosquitoes that may transmit disease and virus
  • Fast-drying formula contains a coat conditioner for a non-sticky application, and works with the biology of your dog by spreading through the oils of their skin
  • Formulated with an Insect Growth Regulator (IGR) to break the flea-life cycle


DO NOT USE ON CATS. Keep cats away from treats dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian. Do not allow children to apply this product. Do not use more than one tube per dog/puppy and do not treat more than once per month. Do not allow your dog/puppy to ingest this product. Do not bathe your dog 48 hours prior to application.

Active Ingredients

  • Etofenprox 50.00%
  • Piperonyl Butoxide 9.10%
  • N-octyl bicycloheptene dicarboximide 0.91%
  • Pyriproxyfen 0.45%
  • (S)-Methoprene 0.23%

For Bio Spot Defense Refill, Click here.

See all items by Bio Spot

  • Item Number
  • Breed Size
    Medium Breeds, Large Breeds
  • Lifestage
    Adult, All Stages


  • OPEN: Use finger scoop to lift open green door.
  • LOAD: To load, place tube white side up into the open Smart Shield applicator with front of tube placed under tab on door. Ensure that tube fits securely in the Smart Shield applicator.
  • CLOSE: Gently close the green door and the tube will snap open.
  • APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog’s/puppy’s skin. Press circle on green door once at each of four or five evenly placed spots, for large or extra-large dogs (or at each of two to three evenly placed spots for medium or small dogs) between the shoulder and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog’s/puppy’s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy 12-24 hours after treatment will help to distribute the material over the skin.
  • DISPOSE: When finished, hold the Smart Shield® applicator over trash. To dispose of empty tube, open green door and drop empty tube into trash or offer for recycling if available. Close applicator device door and store in original package.
  • RETREAT: Do not reapply product for 30 days. Do not treat more than once per month.

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The 3-Step Solution to Pest Prevention

Bio Spot follows the philosophy that pest-free is the way to be—and that's why they offer full coverage for your dog, your home and even your yard. Arming you with everything it takes to keep fleas, ticks and other pests away, Bio Spot is proactive care made easy. In fact, many of their products contain the Infest Stop ingredient, which safely kills flea eggs and larvae before they ever develop into breeding adults.

The 3-Step Solution to Pest Prevention
Protect Your Dog

Protect Your Dog

Pull out every stop against fleas, ticks and even mosquitoes with Bio Spot's variety of treatment and prevention options. Including spot-on applications, collars, sprays and shampoos, Bio Spot has a solution that fits every need and lifestyle. And the best part? They all offer continuous, long-lasting protection to stop the life cycle in its tracks.

Defend Your Home

Pests don't just live on your dog—they live in your home too. And with that in mind, Bio Spot offers defense on the home front. Including a spray that reaches just about everywhere, and a carpet and upholstery powder that controls re-infestation for up to a year, Bio Spot keeps uninvited guests from getting comfortable.

Defend Your Home
Guard Your Yard

Guard Your Yard

The final step in the process, the Bio Spot yard and garden spray takes care of pests at their source. Great for your lawn, trees, shrubs and flowers, the spray is easy to use by attaching to a hose and covering up to 5,000 square feet in no time flat.

About Bio Spot

Bio Spot aims to care for your pet from nose to tail. They know that cats and dogs deliver unconditional love, and that pet parents want to give them the best in return. That's why all Bio Spot products are created to proactively care for their health and well-being—because a healthy and active pet is a happy pet. And happy pets make happy homes.

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About Bio Spot

Customer Reviews

55 reviews 55 Reviews 3.4 out of 5 Stars

64% Recommend

64% of reviewersrecommend this product

3.4 / 5
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  • Don't waste your money!!

    By on

    I tried this because it was a little cheaper than the K9 Advantix II I normally buy. I have bathed and treated my dog twice in a week and she is still covered and miserable. I will go back to what I know works.I personally love Chewy.com and this is the first time I have gotten a product I didn't love.

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  • Recommend if given before they have fleas only

    By on Top 1000 Contributor

    Would only give if you are sure they have no fleas, worked several months last year as a preventative, but my dogs both had a few fleas this year, I gave it & it did not work at all. So I have to now purchase advantix 11 which I know works, but does not come in single packets. I have a very small & a large dog, so have to order 2 different sizes, on a limited budget, can only afford single dose for each month, so ordered for one, can't do the other until next month.

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  • Greasy mess

    By on

    this left a greasy stripe from back of my dogs neck to his tail that lasted for days. I couldn't pet him without getting it all over my hands. Plus he lives in the house. I screwed up and bought 2 boxes because it was a good price and I was thinking that the mosquitoes were going to be bad this year. Most of the product was wiped off with a paper towel or by him on the carpet and couch.

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  • Doesn't work!

    By on

    I put this on both of my dogs. It has not had any affect on the fleas at all! I would not recommend this product to anyone. My poor dogs are itching like crazy. Going to find something better. I have a lab, which I shaved because I know it is hard for flea medicine to get to her skin through her thick fur. I also have a dingo mix who has short fur. Both are still covered with fleas. Will resort to bathing and finding another more effective product.

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  • Worst product ever

    By on

    I put this on my dog and the same day he had 4 ticks on him. I left it and the next day had 5 more. This does not work for along hair dogs at all. My poor baby is getting eaten alive because I choose this product shame on me. I have to give it a star on the system but it deserves none

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  • it works all the time

    By on

    I have used this for my dogs. Never had a problem with flea or tick.

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  • Bio Spot inexpensive and it works.

    By on

    I have used this product for years and have always been very satisfied

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  • So Far So Good

    By on

    So Far So Good. My bully has only had one flea after application and that was because he sun bathes and I'm sure that lonely one just hoped on for a ride. He seems to not be infested with critters and that's always deserves a '5 star' rating from this mama!

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  • Works Great

    By on

    Bio Spot is all I have ever used. It has always worked for my dogs.

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  • Does NOT work

    By on

    I bought this for my 2 large dogs, 2 med dogs, and 3 cats. None of it worked on the fleas, ticks, or mosquitoes!

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