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Bio Spot Active Care Flea & Tick Spot On for Medium Dogs (15-30 pounds)

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Bio Spot Active Care Flea & Tick Spot On for Dogs ensures continuing long-term protection for your pet. Bio Spot Defense topical gel kills adult fleas and ticks and contains an insect growth regulator to kill flea eggs and larvae for up to 30 days. Included applicator helps keep the liquid off your hands, makes it easier to part your dog's fur, gets liquid down to your dog's skin and is easy to load and apply.

Key Benefits

  • Includes Bio Spot Smart Shield Applicator which helps keep the liquid off your hands, makes it easier to part your dog's fur, and gets liquid down to your dog's skin
  • For use on dogs and puppies 12 weeks of age or older that are 15-30 pounds
  • Kills fleas, flea eggs, flea larvae and deer ticks for up to 1 month. Also kills mosquitoes that may transmit disease and virus
  • Fast-drying formula contains a coat conditioner for a non-sticky application, and works with the biology of your dog by spreading through the oils of their skin
  • Formulated with an Insect Growth Regulator (IGR) to break the flea-life cycle


DO NOT USE ON CATS. Keep cats away from treats dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian. Do not allow children to apply this product. Do not use more than one tube per dog/puppy and do not treat more than once per month. Do not allow your dog/puppy to ingest this product. Do not bathe your dog 48 hours prior to application.

Active Ingredients

  • Etofenprox 50.00%
  • Piperonyl Butoxide 9.10%
  • N-octyl bicycloheptene dicarboximide 0.91%
  • Pyriproxyfen 0.45%
  • (S)-Methoprene 0.23%

For Bio Spot Defense Refill, Click here.

See all items by Bio Spot

  • Item Number
  • Breed Size
    Small, Medium
  • Lifestage
    Adult, All Stages


  • OPEN: Use finger scoop to lift open green door.
  • LOAD: To load, place tube white side up into the open Smart Shield applicator with front of tube placed under tab on door. Ensure that tube fits securely in the Smart Shield applicator.
  • CLOSE: Gently close the green door and the tube will snap open.
  • APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog’s/puppy’s skin. Press circle on green door once at each of four or five evenly placed spots, for large or extra-large dogs (or at each of two to three evenly placed spots for medium or small dogs) between the shoulder and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog’s/puppy’s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy 12-24 hours after treatment will help to distribute the material over the skin.
  • DISPOSE: When finished, hold the Smart Shield® applicator over trash. To dispose of empty tube, open green door and drop empty tube into trash or offer for recycling if available. Close applicator device door and store in original package.
  • RETREAT: Do not reapply product for 30 days. Do not treat more than once per month.

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The 3-Step Solution to Pest Prevention

Bio Spot follows the philosophy that pest-free is the way to be—and that's why they offer full coverage for your dog, your home and even your yard. Arming you with everything it takes to keep fleas, ticks and other pests away, Bio Spot is proactive care made easy. In fact, many of their products contain the Infest Stop ingredient, which safely kills flea eggs and larvae before they ever develop into breeding adults.

The 3-Step Solution to Pest Prevention
Protect Your Dog

Protect Your Dog

Pull out every stop against fleas, ticks and even mosquitoes with Bio Spot's variety of treatment and prevention options. Including spot-on applications, collars, sprays and shampoos, Bio Spot has a solution that fits every need and lifestyle. And the best part? They all offer continuous, long-lasting protection to stop the life cycle in its tracks.

Defend Your Home

Pests don't just live on your dog—they live in your home too. And with that in mind, Bio Spot offers defense on the home front. Including a spray that reaches just about everywhere, and a carpet and upholstery powder that controls re-infestation for up to a year, Bio Spot keeps uninvited guests from getting comfortable.

Defend Your Home
Guard Your Yard

Guard Your Yard

The final step in the process, the Bio Spot yard and garden spray takes care of pests at their source. Great for your lawn, trees, shrubs and flowers, the spray is easy to use by attaching to a hose and covering up to 5,000 square feet in no time flat.

About Bio Spot

Bio Spot aims to care for your pet from nose to tail. They know that cats and dogs deliver unconditional love, and that pet parents want to give them the best in return. That's why all Bio Spot products are created to proactively care for their health and well-being—because a healthy and active pet is a happy pet. And happy pets make happy homes.

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About Bio Spot

Customer Reviews

12 reviews 12 Reviews 3.8 out of 5 Stars

75% Recommend

75% of reviewersrecommend this product

3.8 / 5
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  • Greatest prices

    By on

    Have used this product before and liked it but increased prices had me turning to other name brands. When seen this on Chewy and had to order and then saw another couple of things and products were here almost over nite. Great company

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  • Works great

    By on

    I'd say for the price it's the best flea medicine you can get for your dog. We've tried all kinds of over the counter brands and this one worked the best.

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  • Seems to work

    By on

    Seems to be working pretty well. Haven't seen a single flea since I applied it. Have used it before on much later dogs.

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  • Love this product

    By on

    I have used it for about a year in Arkansas with my fur babies. I originally bought it for the mosquitoes that would swarm my sweet pup, and it Works! This is the only product I use for my fur babies, because it is the only one that I have tried that didn't give them an allergic reaction and still worked how it was supposed to.

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    By on

    I wasted my money on this product, it does not work at all. I have had to go back and buy something else. I read the reviews and still continued to order, which was a bad decision on my part, this was a complete waste of my money

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  • Service was great. Arrived fast and in good shape.

    By on

    I was completely satisfied. The service was very good. Well done.

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  • disappointed

    By on

    My dog is still infested with fleas. I had to buy a spray to spray him down with. We are still having an issue with the fleas but at lest the other spray kills most of them.

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  • Okay, I guess

    By on

    This isn't my first choice for a flea & tick med...I prefer the Soresto collar, but my Russell keeps losing them in the woods when she goes for a run with my husband, and they are too expensive to keep replacing. I still find ticks on her from time to time, but no fleas. Easy application, but it rubs off on rugs and furniture, and you can't pet the dog for a day or two, just like with any other topical. I guess it works as well as the more expensive topicals, even though it doesn't repel mosquitos. If I keep finding ticks, I will go back to Advantix, though.

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  • Fleas were not affected by this product. Dog still scratched.

    By on

    Product does not seem to kill fleas, despite applying the product on 4 areas of our dog's back, as directed.

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  • Good flea product

    By on

    Best product for price, and free shipping offer!!!!!!

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