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Bio Spot Active Care Flea & Tick Spot On Refill for Dogs (3 Treatments)

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Temporarily out of stock
61-150 lbs
  • 15-30 lbs
  • 61-150 lbs
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Bio Spot Active Care Flea & Tick Spot On for Dogs ensures continuing long-term protection for your pet. Bio Spot Active Care topical gel kills adult fleas and ticks and contains an insect growth regulator to kill flea eggs and larvae for up to 30 days. Five sizes are available to fit your dog’s needs. 

Key Benefits

  • Intended to be used with the Bio Spot Smart Shield Applicator
  • For use on dogs and puppies 12 weeks of age or older that are 61-150 pounds
  • Kills fleas, flea eggs, flea larvae and deer ticks for up to 1 month. Also kills mosquitoes that may transmit heartworm disease or West Nile virus
  • Fast-drying formula contains a coat conditioner for a non-sticky application, and works with the biology of your dog by spreading through the oils of their skin
  • Formulated with an Insect Growth Regulator (IGR) to break the flea-life cycle


DO NOT USE ON CATS. Keep cats away from treats dogs/puppies for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian. Do not allow children to apply this product. Do not use more than one tube per dog/puppy and do not treat more than once per month. Do not allow your dog/puppy to ingest this product. Do not bathe your dog 48 hours prior to application.

Active Ingredients

  • Etofenprox 50.00%
  • Piperonyl Butoxide 9.10%
  • N-octyl bicycloheptene dicarboximide 0.91%
  • Pyriproxyfen 0.45%
  • (S)-Methoprene 0.23%

See all items by Bio Spot

  • Item Number
  • Breed Size
    Large, Giant
  • Lifestage
    Puppy, Adult


  • OPEN: Use finger scoop to lift open green door.
  • LOAD: To load, place tube white side up into the open Smart Shield applicator with front of tube placed under tab on door. Ensure that tube fits securely in the Smart Shield applicator.
  • CLOSE: Gently close the green door and the tube will snap open.
  • APPLY: The dog/puppy should be standing for easy application. To apply, use tip to part hair and get next to dog’s/puppy’s skin. Press circle on green door once at each of four or five evenly placed spots, for large or extra-large dogs (or at each of two to three evenly placed spots for medium or small dogs) between the shoulder and the base of the tail. Do not apply an excessive amount of the solution at any one spot that could cause some of the solution to run off the side of the dog/puppy. Do not spread this product by hand over the dog/puppy. Although the dog’s/puppy’s skin and hair oils will distribute the application over the entire dog/puppy, brushing the dog/puppy 12-24 hours after treatment will help to distribute the material over the skin.
  • DISPOSE: When finished, hold the Smart Shield® applicator over trash. To dispose of empty tube, open green door and drop empty tube into trash or offer for recycling if available. Close applicator device door and store in original package.
  • RETREAT: Do not reapply product for 30 days. Do not treat more than once per month.

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Customer Reviews

Bio Spot Active Care Flea & Tick Spot On Refill for Dogs (3 Treatments) is rated 4.4 out of 5 by 27.
Rated 5 out of 5 by from Great for the price! So if you read the box, it repels ticks & mosquitos, but NOT fleas. It does KILL fleas, but does not repel them. Knowing this going in, it has worked perfectly for my dogs. I have 4 dogs ranging from 6 to 96 pounds and I use this on all of them. I give my large dogs a bath once per month and my smaller dogs every other week. I have noticed fleas on my pug, but only a couple, and they were all dead. I keep Advantage II on my cats, and I don't have carpet in my home so infestation is a non-issue for me. Overall I'm very pleased with this product and I will continue to use it on my dogs.
Date published: 2016-10-22
Rated 1 out of 5 by from Product does not work Product does not work! Every dog I used this product on still has fleas.
Date published: 2016-12-29
Rated 5 out of 5 by from Fleas and Ticks Works great on all three of our dogs. You get alot for the money.
Date published: 2017-03-06
Rated 5 out of 5 by from Efficient repellant This is one of the few repellants that works against ticks, fleas, AND mosquitos. And the price is lower than some of the repellants that work only on ticks and fleas.
Date published: 2016-10-17
Rated 5 out of 5 by from good quality, good stuff. I used this on my larger dog for a year, had NO problems with fleas, ticks. ... no bug issues at all. Then we got an Aussie doddle mini, used a"companies brand with similar price and ingredients. Mocha got and kept fleas, itching, rubbing on carpets, dispite baths, sprays even powder. I was going crazy. I had to go to Chewy to find this brand, and the right dosage for Mocha. She's 6lbs. Our other is 30lbs. I got it in 2 days, standard shipping! applied it immediately. Mocha quit itching within an hour. We'very not seen or found 1 flea since application. We love this brand! For the cost it works great!
Date published: 2016-08-20
Rated 5 out of 5 by from Effective I have 5 dogs ranging from small to large and buying anything for all 5 can get expensive quick. I never sacrifice quality and safety for low costs. I have tried these on all of my 5 dogs and have not seen fleas or ticks or any side effects. We live in Texas were it can be flea, tick and mosquito season all year long so I need things that work. My dogs are usually inside dogs the most time they spent outside will be 4 hours because of the heat so I have not tested it 24 hours 7 days a week outdoor exposure to pets. The liquid can be easily seen after applying and depending on the dog hair could probably linger or be noticeable but they arent bothered by it.
Date published: 2016-05-25
Rated 5 out of 5 by from Great protection, great price. I researched fro some time before choosing this brand- I'd never heard of it, so I was reluctant to try it. I've been using Biospot for about 5 years now, and I have to say, the protection is just about 100%. I live in tick heaven, and I NEVER find ticks on my dogs. Fleas are a thing of the past. Provided you use it as recommended, and bathe the dog at least once a a month, it totally works. Least expensive product on the market, as far as I can tell.
Date published: 2014-05-28
Rated 3 out of 5 by from flea overload I have used this product a number of times. It worked very well when I lived in northern Illinois. I moved to Nashville, TN recently. It worked great at the beginning of spring. A couple of months later, it hardly worked at all. Not only did he get infested all 3 of my indoor cats did too. Yes they get treated every month too. Fleas are a big problem down here. Especially if the tempreture does not drop below freezing over the previous winter. I have also always treated my yard every year for fleas. My dog is a 90 pound long haired German Shepherd. It gets very hot down here so I don't leave him out for long. We need super strong stuff down here.
Date published: 2016-12-17
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