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Frontline Plus Flea & Tick Treatment for Dogs (89-132 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
  • Lifestage
    Puppy, Adult


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

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162 reviews 162 Reviews 4.7 out of 5 Stars
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  • Works Great!!

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    We live in the country, we always use flea treatment but this year the ticks are really bad out here. I was looking for a new product that didn't just repel ticks, but kills them. Since using the frontline plus we haven't seen one tick on any of our dogs or cats. And it seems to be working well for the fleas as well.

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  • Chewy frontline and service

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    My owner only buys FRONTLINE Plus from Chewy. They say it is delivered real fast so I don't run into the itches. They use FRONTLINE Plus because I had seizures with the pills for fleas. Since my owners have been using this product I have had a lot less problems. That is important because I love hiking and swimming with my owners. I am protected from itches. I tell all my dog neighbors about Chewy and how fast they get the food, treats, and coats we order here.

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  • Thank you Chewy

    By on

    I would like to thank Chewy.com for their business. I had seen the commercials and always thought "why do that, I can just pick it up at the grocery or vet. Then, a couple of months ago, I decided to check out your website (I was trying to find a less expensive version of what I was buying from our vet. I am so glad that I did. You have all of the name brands, for quite a bit less. Also, the free, fast shipping is great! I am thankful for your website and offering such a variety of pet supplies (and letting your clients change up the order each month, if needed).

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  • frontline plus for dogs

    By on

    im very happy with my latest perchase, Frontline plus for 89 to 132 lbs its the best price anyware and I shop for price, couldnt beat it anywere thank you Chewy in fact all your product are great prices thats why i shop there Thank you again. Kim

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  • Not sure if this still works on ticks.

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    I have been using this for years, but lately I've been finding ticks attached to my dog. She has recently has come back lyme positive. So the vet has switch her to a chewable tick prevention.

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  • Great product at the best price

    By on

    I have 5 dogs varying from 50lbs to 5 lbs. It's important to get the best price on my flea & tick repellant as possible. After shipping, chewy.com was better than the competition. Thanks!!

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  • Go-to flea and tick control product

    By on

    Have tried a number of other products for flea and tick control, including generics/knockoffs of FrontlinePlus . Actual brand FrontlinePlus has worked the best for me. Loved the sale Chewy sale price and speedy delivery.

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  • No more fleas!

    By on

    I purchased this product for two very large dogs. Tis the season for fleas and ticks here in Indiana. I've used this on them for two months and have not seen one flea. I will definitely recommend and purchase again.

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  • Very Competative pricing

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    Pricing is the best that I have found on line. Now every time we need something for Jack we check chewy first. We also purchase his dry dog fod and vitamins.

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  • Great product

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    We have 9 dogs. Flea and tick protection can get really expensive. Chewy has the best price and you can't beat how fast their delivery is! I had my order in less than 24 hours!

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