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Frontline Plus Flea & Tick Treatment for Dogs (89-132 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
    Large Breeds, Giant Breeds
  • Lifestage
    Adult, All Stages


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

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202 reviews 202 Reviews 4.7 out of 5 Stars

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94% of reviewersrecommend this product

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  • Save your money

    By on

    I haven't had the need to use chemicals on my dogs until this year but I could not get rid of the fleas so I decided to cave. I put it on them as directed, vacuumed house and furniture, washed dog beds. They still have fleas. It didn't do a thing to kill or repel or anything. What a waste of $60 and I am jobless right now so I have to be careful where I put my money. Also I didn't go to my grandson's birthday party because I didn't want to bring fleas with me (I take my dogs when traveling out of town). Vet says I cannot use another treatment of any sort until 30 days has past, only baths.

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  • Excellent protection for us since 2007

    By on Top 250 Contributor

    I've used Frontline / Frontline Plus since 2007 on nine dogs with excellent results. All my pups and guardian dogs have arrived uninfested, and stayed that way with this product. We are in Minnesota, (which isn't as cold as it used to be) and have a very strong tick season. Not one tick in over ten years! No fleas, ever. Although I use as few chemicals as possible on my dogs, the protection and safety that Frontline provides is absolutely worth it, and Chewy's price is a terrific savings.

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  • Excellent Price!

    By on

    Frontline has been our "go to" flea/tick preventative. We live in Georgia and take our dogs on hikes or camping trips in the woods at least weekly. We have never had an issue with Frontline and love the price Chewy provides. With four large dogs, it can get expensive with preventatives and Chewy has helped us save money! THANK YOU!

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  • Did not work at all

    By on

    I have several dogs and this product did not work for any of them. I had even sprayed my yard to make sure there was no chance of more fleas getting on them. I could still see fleas on my dogs for days after treatment, and had to purchase a different product that my vet recommended. Total waste of money.

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  • The 5 stars are for Chewy!

    By on

    Frontline is frontline, you can get it anywhere. When I go into stores it is hit or miss. They may or may not have what I traveled to get. I prefer to go online to Chewy. They always have it, it is here in 24-48 hours, the prices are better and I have more free time for other things. Thanks Chewy!

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  • Excellent product - great service

    By on

    We have used Frontline Plus for over five years on our great danes and have found it to be the most effective preventative against fleas and especially ticks. Our property is prone to ticks and we have tried other products and none have performed as well as Frontline.

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  • Fast and easy

    By on

    i received a coupon in the mail. i thought i would check out your prices and realized they were cheaper than what i usually buy at the store. I received my purchase in no time at all. it was fast and easy and I will be ordering from your website again real soon. Thanks so much

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  • Waste of money

    By on

    I've used Frontline Plus for many years. This is the 1st time its not worked at all. I am so disappointed and all my babies are still scratching and I'm constantly picking off fleas on them and me. Driving us all crazy!!! Did Frontline change the formula or fleas immune? Idk but it doesn't work anymore. I have limited funds and wish I could get my money back to try something else. Lesson learned, don't buy it again.

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  • Kills Fleas and Ticks

    By on

    I really like this product to keep my dogs from getting fleas and ticks. They live outside all the time, so it's important to keep them from getting fleas and ticks. It's easy to use and my dogs have no adverse side effects.

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  • Frontline is a great product

    By on

    We have used Frontline for many years and have yet to have any problems with fleas or ticks. I apply this product on my dogs at night before bed so it is absorbed by the skin while they are inactive. Using Frontline along with a separate heartworm product, rather than the two combined, allows me to discontinue the Frontline if I care to while giving them heartworm prevention year round.

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