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Frontline Plus Flea & Tick Treatment for Large Dogs (45-88 pounds)

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In stock
  • 3 treatments
  • 6 treatments
- Quantity +


  • Item Number
  • Breed Size
    Medium, Large
  • Lifestage
    Puppy, Adult

Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older between 45-88 pounds
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths

See all items by Frontline

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Customer Reviews

Rated 4.7 out of 5 by 303 reviewers.
Rated 5 out of 5 by Expensive but worth it. We've tried so many knock off brands but always come back to Frontline Plus. Nothing else is as effective, easy to apply and quick to absorb, leaving no greasy residue on our dog's coat after about a day. We love it! October 12, 2016
Rated 5 out of 5 by Great Product Been using this for several years and never had any problems or reactions. The delivery was super fast and the price was comparable to local store, but with free shipping and the first order coupon made the right choice for us. October 3, 2016
Rated 5 out of 5 by Do not bathe Best results when used days before or after bath since it works in oil glands. Most times ineffective is when applied to a freshly bathed dog. I use on 4 dogs, do 2 every other month. 2 Dogs on even months, and 2 dogs on odd months. No fleas or ticks for years in southern climate. October 4, 2016
Rated 5 out of 5 by Great product I've been using Frontline on my dog for 11 years. I've never seen a flea or tick on her and I have 3 acres of woods behind my home. October 4, 2016
Rated 5 out of 5 by Frontine Plus Frontline Plus has kept my Old English Sheepdog healthy for 4 years. Chewy makes it easy to order and delivery is fast and efficient. October 4, 2016
Rated 5 out of 5 by Works good for my 65lb Pup! I have always used Frontline Plus, even on my small pups - they are under 20 lbs. We recently rescued a large pup and this works great for her as well. No ticks or fleas in on them or in our house. Good product - use gloves when you apply it and make sure you put it on the back where they cannot reach the area to lick it off...it could be fatal if ingested. September 30, 2016
Rated 5 out of 5 by Great product. Have used this product on my dogs for over 20 years. Recommend for use on pets. October 2, 2016
Rated 1 out of 5 by Did not work This product did not work for us!! Very upsetting. We had used Capstar first, then applied after 24 hours. The fleas got worse after a few days!! September 30, 2016
  • 2016-10-24 T05:37:56.272-05:00
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