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Frontline Plus Flea & Tick Treatment for Large Dogs (45-88 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older between 45-88 pounds
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
  • Lifestage
    Puppy, Adult


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

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409 reviews 409 Reviews 4.7 out of 5 Stars
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4.7 / 5
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  • Did not work

    By on

    I had used Advantix 2 before but thought I might try Frontline since it said it treats dogs 45-88 pounds, and one of my dogs is 45 and the other is 60. It did not work at all for either of them. I used Advantix two weeks later, along with a Capstar tablet covered in peanut butter for 2 days in a row and they are not scratching anymore. I only used Capstar with the Advantix for peace of mind. I now just give them food-grade diatomaceous earth with their food everyday as a preventive and to help with the worms they got from eating the fleas.

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  • Trusted flea meds.

    By on

    Years ago you could only get this from your veterinarian and it was the recommended brand from them. It has always worked well for us with no side effects. I am wary of any of the off brands and the new chewables since they can have side effects, some of which are serious. Highly recommend this product for both dogs and cats and it's super convenient to buy it from Chewy.

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  • This is safe for households with cats who live with a dog.

    By on

    Our vet tried to sell us the new Frontline Gold. Good thing I took the time to read the packaging at the vet's office because the Gold version says not to allow cats to be in contact with treated dogs for 24 hours. The vet was unaware of this. I ordered regular Frontline Plus from Chewy's instead. The only warning on this is not to USE it on cats.

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  • It Works Best of Any brand

    By on

    I've used Frontline for years because it works best of any of the other brands. Chewy had the best prices also unless somebody is giving it away. Came in one day and Frontline works like it says on the box. Dogs don't get sick or irritated with it like a flea/tick collar.

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    By on

    The was my 1st time buying this product from Chewy. But the customer service representative was very knowledgable and assured me this product is purchased from the manufacturer which relieved my concern of getting a product that might harm my sweet precious babies! Thank you Chewy!

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  • Frontline is great!

    By on

    My 4 legged girl is doing great on the Frontline Plus, it works wonderful. Thank you for loving our family members as much as we do and taking such great care and pride in your business to please them and their pet parents.

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  • The best flea control

    By on

    Great price and ships right to my home love it!!! I love that this company has given me some time back by not having to go into a store and lug all the dog food I buy by myself. Now when it ships too my house my husband and son bring it in and take care of it for me!

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  • Didn't work

    By on

    I applied first dose and didn't see any results so I waited to apply the second one to see if it would work and I still saw fleas on my dog. Asked the vet about it and he said this product hasn't worked since 2013.

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  • Frontline Plus

    By on

    Love Chewy! I order my dogs food, their vitamins, and recently ordered two different Frontline flea & tick preventative for them. I price compared with all major retailers and Chewy was the best priced, and I love the fast overnight shipping! I have not found any signs of fleas or ticks on any of my dogs I used it on, or my indoor cats, as well as in my home. I will be adding this product to my auto ship order!

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  • Way to keep the fleas and ticks at bay.

    By on

    I live near a river and wood and the dog scuttles through the tall grass and thickets for each walk. I never have to worry about those pesky fleas and ticks. My dog is 42 pounds falling just between big and normal. On advice I buy big dog in summer and regular over the snowy winters. Won't get anything else.

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