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Frontline Plus Flea & Tick Treatment for Medium Dogs (23-44 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older between 23-44 pounds
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
    Small Breeds, Medium Breeds
  • Lifestage
    Adult, All Stages


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

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261 reviews 261 Reviews 4.6 out of 5 Stars

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94% of reviewersrecommend this product

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  • Great customer service!

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    I purchased the frontline as a replacement for Advantix (the product worked well, but my dog was having a skin reaction to it - which she is prone to). I haven't tried the product yet, but should mention that Chewy's customer service on this was top notch! I had a full box of Advantix which I bought from Chewy but could no longer use (due to dog's allergies). The rep at Chewy refunded me the for the box of Advantix (asked that I take it to a SPCA, because they can't take back things like that), sent me an box of Frontline, and waived the shipping fee. Overall, great customer service!

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  • Didn't work at all

    By on

    A week ago I used Frontline Plus on my dog and it hasn't killed the fleas at all. My Cavalier King Charles Spaniel has severe flea allergies and hoped this might help, but she's worse! I also have 3 cats and used the Frontline Plus for cats and didn't work for them either. My home is all wood floors and I constantly vacuum and mop and regularly was all bedding. My vet told me not to purchase it because the fleas are immune to it but I tried anyway because of all the positive reviews here. Never again.

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  • No bugs for me.

    By on

    Best price I've found even with some store's/vet's offer of, "buy 3, get 1 free." I've used this since my seniors were puppies, it works. My dogs have never had a flee on them. Once after spending a lot of time in a park, one of my dogs got a tick on his eye lid. The vet removed it and said this product absorbs into the large muscles and apparently isn't as effective on the face. I avoid that park and have continued to use Frontline without further incident. Cons: It is oily and takes a few days to absorb wherein it isn't noticeable. My dogs have huge coats, it maybe messy with short coated dogs.

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    By on

    We don't have any fleas or ticks where we live, but we camp in areas that do. Typically we camp only a few days to a few weeks at a time, so it is difficult to justify the dose cost, but I think not bringing fleas into the trailer or bringing them home is worth it (in my opinion, cheaper products may or may not work). My 2 dogs are about 30 lbs. and I was afraid they may have a reaction to the dose, but neither dog had a reaction. We made the trip with no fleas or ticks, always a good thing.

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  • Flea Meds for my Pets

    By on

    I recently ordered flea medication for both my dog and my cat. The prices were so much better than the local pet stores and with 6 treatments each vs the 2 treatment option at the local store. My "little girl" Shih Tzu is almost 16 years old and I also ordered puppy pads. These are a constant with her at this stage of her life. All products were delivered as expected. I am very well satisfied with Chewy and encourage everyone to give it a try.

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  • Frontline Plus -- Excellent Price and Quick Service

    By on

    This was the first time I ordered from Chewy, and I was extremely pleased. I always use Frontline Plus for my 10-year-old Pug-A-Poo, and I always price-shop when it's time to order. Chewy, by far, had the best price for a six-month supply, thanks in part to their $15 off coupon offer. The order arrived within several days, faster than estimated. I will definitely order from Chewy again!

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  • Frontline plus for dogs and cats/Potty Pads

    By on

    I live in south where fleas multiple like rabbits, Advantage doesn't work in our area, my vet recommended using frontline plus I use it along with Sarasto flea collar for extra protection . My pets are free of fleas . PS: I just started use potty pads I purchased from your company. I like they size and high quality.Will be reordering as needed.

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  • Chewy and frontline

    By on

    I have used frontline for years and it has always worked well. However I'd never ordered it or anything else from Chewy before so that's is what my review is about. Cost was less than I'd been paying either from my vet or an online company. Ordering was easy. And it came in 2 days. It was easy to track package and I since I opted to have in transit notification I always knew where the pkg was. I have since ordered more from Chewy and will continue to do so.

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  • Protecting My Bianca from Fleas/Ticks

    By on

    Been using this product for years to help protect my dogs from fleas/ticks. Frontline Plus was recommended by my vet whom I have entrusted the care of my dogs for over 35 years. Chewy.com offers fast delivery and competitive pricing of this and other items.

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  • Great product and price when on sale

    By on

    I have used Frontline for about twenty years and have never found a flea, tick or pest anywhere in my home. Many customers are on a fixed income and need to find the best price. It is really nice when I can find Frontliine on sale. Highly recommended.

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