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Frontline Plus Flea & Tick Treatment for Medium Dogs (23-44 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older between 23-44 pounds
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
  • Lifestage
    Puppy, Adult


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

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206 reviews 206 Reviews 4.6 out of 5 Stars
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94% of reviewersrecommend this product

4.6 / 5
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  • I love Chewy.com!

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    I have used this service 2 times now and both times it was very fast and easy to use! The first time I bought dog food and it was great not to have to haul that big bag home! I'll never go back to buying at the store....this was cheaper and easier!

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  • So Important to Have No Fleas!!!

    By on

    I needed to compare this old stand-by with alternate products I have become aware of. The rep on the phone when I ordered was super knowledgeable, patient, and helpful. I have never had a problem with this product, and Chewy's prices are very fair.

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  • Not sure if this had expired date

    By on

    I have always used this and Bailey never had any problems, I put it on earlier than normal due to warm weather and ticks being out, isn't repelling the ticks latching on and I'm having a heck of a time taking off, on head and ears which is very close to back neck area where I apply! I thought what a good price, to good to be true, but I guess u get what you pay for. Chewy has always made Bailey happy, but not this batch of frontline plus, because it's only a couple weeks I'm not sure if I should try another dose, vet says no! Probably old and that's why the good price, sorry guys, We love chewy but I just can't say that I was happy!

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  • Doesn't work for ticks

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    In my experience, this does not work for ticks. I am not sure if it's because I live in New Hampshire, where ticks are absolutely rampant so it's unavoidable, but regardless, ticks still attach to my dogs while using this.

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  • Fleas and Ticks

    By on

    My Bichon is 10 years old and we have never used anything but Frontline on her. It works great. Apply as directed to get the maximum protection for your furbaby. She is very picky about her treats, so I also order them from Chewy.com. The prices and the customer service are fantastic.

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  • Don't buy the cheap stuff!

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    It's simple: Frontline works. I've tried the cheaper brands from box stores, then had to fight fleas until it wore off and I could go back to Frontline. Sooo, don't waste your money on the cheap stuff. In the long run, Frontline is cheaper, because it works!

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  • Love Chewy

    By on

    We like your price and not having to drive 25 miles to the store to shop. Love the delivery right to our front door! Our Shelby doesn't use up her food for while, but we will keep ordering from you! Love your store.

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  • Fan of Frontline

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    I've used this product for many years on both my own dogs and my rescues. Been effective and price was very good, especially now that my Vet hasdiscontinued carrying Frontline made this even greater find and buy on CHEWY!

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  • Great Product

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    We ran out of this product and needed to get it very quickly. It so happened that we could purchase a six months supply at a great savings which is important in these economic times.

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  • Easy to use

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    This was so easy to apply and seems to be working great. My 5 month old Siberian Husky loves to be outdoors and walk wooded trails. It really seems to work great, no problems.

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