On Sale

Frontline Plus Flea & Tick Treatment for Small Dogs & Puppies (up to 22 pounds)

  • Was:


  • Price:

    $68.99 FREE 1-2 Day Shipping on this item

  • You Save:

    $31.00 (31%)

In stock
6 treatments
  • 3 treatments
  • 6 treatments
- Quantity +


Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older between 5-22 pounds
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths


Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Breed Size
    Extra Small & Toy Breeds, Small Breeds
  • Lifestage
    Puppy, Adult, All Stages


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

  1. Frontline Plus Use & Care Instructions

Pet Lovers Also Bought

Customer Reviews

439 reviews 439 Reviews 4.6 out of 5 Stars

92% Recommend

92% of reviewersrecommend this product

4.6 / 5
Write a Review

You've Already Reviewed This Item

Showing 1-10 of 439 Reviews

Sort by:
Filter by:
  • Do you hate flees...?

    By on

    I've always used Frontline on my dogs. Living in San Francisco and having been suffering from a 7 year drought, the flees became resistant and were not getting "killed off" in the winter time due to lack of rain and warm temperatures. Well...the drought is over and there are no more flees. I like Chewy for the low prices and the convenience of having it delivered to my door. Chewy always has what we need and what he wants... :-)

    You liked it! Something went wrong. Please try again later. Report
  • Had to change flea medicine

    By on

    I had used K9 Advantage for several years and was very pleased. Then, for some reason this year my two maltese were "covered" in fleas as if they had no flea medicine on. I literally was sitting down with a bowl of alcohol and a swab and picking off around 60-65 per day between the two of them (yes I counted). I switched to Frontline and they are flea-free currently. My guess is the fleas had gotten used to K9 advantage. I will switch again if the problem resurfaces.

    You liked it! Something went wrong. Please try again later. Report
  • Love Chewy.com

    By on

    Glad to have found Chewy.com. It is so convenient to know my dog food just shows up at my front door, thanks to autoship. Last month, I called the day before my order was ready to be shipped and they were able to add Frontline to that order. The savings are great and not having to lug dog food home is great!

    You liked it! Something went wrong. Please try again later. Report
  • No longer effective

    By on

    I have been using Frontline for over a year with no problems. However, in the last month, my dogs have been getting fleas like crazy. I called up my vet, and I was told that fleas are becoming more and more immune to the active ingredients in Frontline. She recommended an oral treatment, flea collar, or alternative topical treatment.

    You liked it! Something went wrong. Please try again later. Report
  • Great Price for Fronline Plus

    By on

    We used to get this from our Vet and he has stopped carrying it and found the best price at Chewy.com. Have used this for many years and found it works and don't care for the side effects of the new Flea & Tick monthly that the dog eats. We will stick with Chewy!

    You liked it! Something went wrong. Please try again later. Report
  • So Glad I Found Chewy!!!

    By on

    Started ordering online (I'm usually not too good at this) and so easy. Saving money and couldn't be happier with the service. Order one day and here the next!! Now I try to order everything I need for my dogs from Chewy!!!

    You liked it! Something went wrong. Please try again later. Report
  • Little dog little fleas

    By on

    Great shipping little dog lots of little fleas put this on little fleas die onley product does not seem to last the full 30 days before the fleas begain to return to their feeding ground after 20 somedays

    You liked it! Something went wrong. Please try again later. Report
  • Works on my Maltese

    By on

    My baby is so sensitive to everything but I can use the Frontline without any problems. So grateful. Thank you to Chewy.com for your great prices and unsurpassed customer service!

    You liked it! Something went wrong. Please try again later. Report
  • Front line plus

    By on

    Have used this brand for years and love it. Tried a different brand for a few months but wasn't pleased with results. I trust front line plus to keep ticks and fleas off my pups.

    You liked it! Something went wrong. Please try again later. Report
  • Great product at a great price!

    By on

    We have always used Frontline on our 4 Shih Tzu dogs and have always had great results. We paid much less money here at Chewy for more months of applications, and their service was quick! I would recommend this product and have already told a friend about Chewy. I will continue to deal with this company for this and other products! BRAVO!

    You liked it! Something went wrong. Please try again later. Report