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K9 Advantix II Flea & Tick Treatment for Medium Dogs 11-20 lbs

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6 treatments
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K9 Advantix II Flea Treatment for Dogs offers broad spectrum flea control and protection against ticks and mosquitoes, too. It is specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes. K9 Advantix II also kills all life stages of fleas, repels biting flies and kills lice. It contains imidacloprid, permethrin and pyriproxyfen that work in concert to repel and kill parasites that can potentially transmit disease-causing organisms. K9 Advantix II is a flea treatment for use on dogs 7 weeks and older. Do not use K9 Advantix II on cats.

Key Benefits

  • Specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes
  • Repels and kills ticks of all types including Deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks
  • Prevents fleas on treated dogs from infesting your home
  • Kills fleas on dogs within 12 hours and continues to prevent infestations for a month
  • Contains imidacloprid, permethrin and pyriproxyfen which work to repel and kill parasites that can potentially transmit disease-causing organisms


Use only on dogs and puppies 7 weeks of age and older and weighing 11 to 20 pounds. DO NOT USE ON CATS. Keep out of reach of children. Do not get this product in dog's eyes or mouth. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rate, may occur after using ANY pesticide product on dogs. If signs persist, or become severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.

Active Ingredients

  • Imidacloprid 8.80%
  • Permethrin 44.00%
  • Pyriproxyfen 0.44%

See all items by K9 Advantix II

  • Item Number
  • Brand
  • Breed Size
  • Lifestage
    Puppy, Adult


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Use only on dogs.
  • Remove applicator tube from the package. Use scissors and peel down foil.
  • Hold applicator tube in an upright position. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. The entire contents of the K9 Advantix II tube should be applied evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • Discard empty tube.
  • In cases of severe pest infestations, retreatment is allowable earlier than 4 weeks. Do not retreat more often than once every 7 days. After pest control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

How is K9 Advantix II different from K9 Advantix?

With the addition of an insect growth regulator (IGR), K9 Advantix II kills all life stages of fleas. K9 Advantix II also prevents development of fleas, flea eggs, larvae (maggots), and pupae (cocoons), and prevents fleas on a treated dog from infesting your home.

What is the benefit of repellency?

Repellency helps prevent ticks, fleas, and mosquitoes from attaching, biting or feeding. A repelled parasite doesn’t bite or attach. If it doesn’t bite or attach, it can’t transmit the organisms that may cause disease.

What is the difference between K9 Advantix II and other tick and flea products?

K9 Advantix II repels and kills ticks, fleas, and mosquitoes. It repels biting flies and kills lice, too. Its repellency activity and broad spectrum make K9 Advantix II different from other tick and flea products.

Is K9 Advantix II waterproof?

Yes. There is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

Can I use K9 Advantix II on my cat?

No. K9 Advantix II must not be used on cats because of a cat’s unique physiology and inability to metabolize certain compounds.


Dog Weight K9 Advantix II Volume
10 pounds and under Small Dog 0.4 mL tube
11 to 20 pounds Medium Dog 1.0 mL tube
21 to 55 pounds Large Dog 2.5 mL tube
over 55 pounds Extra Large Dog 4.0 mL tube

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Customer Reviews

K9 Advantix II Flea & Tick Treatment for Medium Dogs 11-20 lbs is rated 4.6 out of 5 by 251.
Rated 5 out of 5 by from Excellent Service I have been using K9 Advantix for years. It has always worked well. Recently, I got lazy and skipped a couple of months and my poor dog wound up with worms. I won't let that happen again. I am always so pleased with my Chewy orders. They come so fast. My dog suggests that you add a little treat to his packages!
Date published: 2017-02-10
Rated 3 out of 5 by from Great product but odd weights I have a 25 pound dog that I have always considered to be a small dog but if I follow the weights listed on the package, I would have to get the large dog product. I get the medium size for dogs 11-20 pounds and always wonder whether it is enough. I have read about dogs getting seizures and other health complications from Advantix and other similar treatments thus the weights seem kind of important. An 11 pound dog is certainly not a medium size dog and a 21 pound dog is not a large. The weights on the product seem way out of wack and make me nervous. Nonetheless, I get the product because it seems to work well.
Date published: 2017-03-20
Rated 5 out of 5 by from This product is the best for flea and tick control. We just moved from the NW to upstate NY. So having lived in the east before I knew we would have a tick problem again. No, the NW doesn't have ticks, or at least I should say we never saw one in the 15 yrs I lived there. So I ordered this product for my 3 dogs, it is a great product and will keep using it. As usual Chewy is the best site for all your pet needs. Their customer service is the best.
Date published: 2017-02-11
Rated 5 out of 5 by from This product protects against mosquitoes too !! I have been really happy with Advantix. It's been a great option for us because it protects against mosquitoes which many of the other flea and tick treatments do not. We RV full time, so we travel to different regions of the country with many of the pests this product protects against. We were in a flea infested area recently, and didn't see a single one on our boy. I love that it only takes a few drops, and the liquid absorbs quickly. We have used Advantix for 2 years now. I highly recommend this product.
Date published: 2017-02-28
Rated 5 out of 5 by from Simple application Simple application and minimal packaging. I liked that there were different quantity choices.
Date published: 2017-02-23
Rated 5 out of 5 by from Helped win war with persistent pests In the midst of the holiday season, I discovered my dog had fleas (I had missed a couple doses of her spot treatment, so the little buggers established a foothold). I bathed her in lemon Dawn, applied her previous spot treatment (which had the same ingredients as Frontline), gave her a dose of Capstar, washed the bedding, throws, and pillows, and applied borax to all of the carpeting, but the fleas were unaffected, and starred biting me! I knew that the spot treatment was the problem because the fleas' life cycle wasn't broken, and the eggs and pupa continued to mature. I contacted our vet, who said that it was reported that fleas had started to develop a resistance to Frontline, so I should try Advantix. I received my order within 2 days (during the holidays), and the day after applying it to my dog (with another dose of Capstar, rewashing everything and vacuuming -- again) there were no signs of fleas on her and I wasn't getting bitten anymore. It's been almost 2 weeks, and so far, no fleas! Advantix ended the war and saved my sanity!
Date published: 2016-01-12
Rated 5 out of 5 by from Keeps Problems at Bay Each month, after my toy poodle's grooming appointment, I apply the K9 Advantix II and she has no problem with bug bites, even though she loves to romp in the barkdust and roll in the grass.
Date published: 2017-02-21
Rated 5 out of 5 by from Excellent product, fast delivery Thanks again to Chewy.com for providing affordable name brand products and unbelievable fast delivery. Very convenient online shopping with awesome customer service when needed.
Date published: 2017-02-16
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