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K9 Advantix II Flea & Tick Treatment for Extra Large Dogs Over 55-lbs

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6 treatments
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K9 Advantix II Flea Treatment for Dogs offers broad spectrum flea control and protection against ticks and mosquitoes, too. It is specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes. K9 Advantix II also kills all life stages of fleas, repels biting flies and kills lice. It contains imidacloprid, permethrin and pyriproxyfen that work in concert to repel and kill parasites that can potentially transmit disease-causing organisms. K9 Advantix II is a flea treatment for use on dogs 7 weeks and older. Do not use K9 Advantix II on cats.

Key Benefits

  • Specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes
  • Repels and kills ticks of all types including Deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks
  • Prevents fleas on treated dogs from infesting your home
  • Kills fleas on dogs within 12 hours and continues to prevent infestations for a month
  • Contains imidacloprid, permethrin and pyriproxyfen which work to repel and kill parasites that can potentially transmit disease-causing organisms


Use only on dogs and puppies 7 weeks of age and older and weighing 55 pounds or over. DO NOT USE ON CATS. Keep out of reach of children. Do not get this product in dog's eyes or mouth. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rate, may occur after using ANY pesticide product on dogs. If signs persist, or become severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.

Active Ingredients

  • Imidacloprid 8.80%
  • Permethrin 44.00%
  • Pyriproxyfen 0.44%

See all items by K9 Advantix II

  • Item Number
  • Brand
  • Breed Size
    Large, Giant
  • Lifestage
    Puppy, Adult


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Use only on dogs.
  • Remove applicator tube from the package. Use scissors and peel down foil.
  • Hold applicator tube in an upright position. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. The entire contents of the K9 Advantix II tube should be applied evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • Discard empty tube.
  • In cases of severe pest infestations, retreatment is allowable earlier than 4 weeks. Do not retreat more often than once every 7 days. After pest control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

How is K9 Advantix II different from K9 Advantix?

With the addition of an insect growth regulator (IGR), K9 Advantix II kills all life stages of fleas. K9 Advantix II also prevents development of fleas, flea eggs, larvae (maggots), and pupae (cocoons), and prevents fleas on a treated dog from infesting your home.

What is the benefit of repellency?

Repellency helps prevent ticks, fleas, and mosquitoes from attaching, biting or feeding. A repelled parasite doesn’t bite or attach. If it doesn’t bite or attach, it can’t transmit the organisms that may cause disease.

What is the difference between K9 Advantix II and other tick and flea products?

K9 Advantix II repels and kills ticks, fleas, and mosquitoes. It repels biting flies and kills lice, too. Its repellency activity and broad spectrum make K9 Advantix II different from other tick and flea products.

Is K9 Advantix II waterproof?

Yes. There is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

Can I use K9 Advantix II on my cat?

No. K9 Advantix II must not be used on cats because of a cat’s unique physiology and inability to metabolize certain compounds.


Dog Weight K9 Advantix II Volume
10 pounds and under Small Dog 0.4 mL tube
11 to 20 pounds Medium Dog 1.0 mL tube
21 to 55 pounds Large Dog 2.5 mL tube
over 55 pounds Extra Large Dog 4.0 mL tube

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Customer Reviews

K9 Advantix II Flea & Tick Treatment for Extra Large Dogs Over 55-lbs is rated 4.7 out of 5 by 491.
Rated 5 out of 5 by from Tried and true I've used K9 Advantix II for almost 20 years on two dogs. Application is easy, though the dogs seem to not like the sensation when I apply it. Very effective for both dogs over the years - even in Florida where other dog owners told me it didn't work for them. The residue (oily application area) is the only drawback, but it DOES help to remind me that I should be careful to not touch the area or allow others to do so. T-Boy, however, does not appreciate being kept out of our pool for a couple of days after application; he misses diving in after his tennis ball - so much ball-chasing time wasted!!
Date published: 2017-03-19
Rated 5 out of 5 by from Should have looked here first. I knew after much study that I wanted to switch from my Frontline Plus to this product because the mosquitos have been so horrible, even through the winter, and this product works on mosquitoes in addition to fleas and ticks. I first ordered from a giant mail order source and a week later I still didn't have the product. Then it got lost in the mail! I had my money refunded and needed to find the product somewhere else. I buy all my food from Chewy and feel like an idiot I didn't look here first! It came in a few days and was almost 10% cheaper. I learned my lesson!
Date published: 2017-02-06
Rated 5 out of 5 by from Best flea repelant in Alabama! I have tried pills, sprays, and collars and have found K9 Advantix to be superior to any other product to keep fleas and ticks from living on my dogs. I have dogs in size from German Shepherd to Shitzu and am amazed at the results using K9 Advantix II. I would highly recommend this product for any healthy dog to keep them free from fleas and ticks!
Date published: 2017-01-18
Rated 4 out of 5 by from Using Advantix for many years... guess what ?..... I have been using advantix for many years.....and just now i WONDER.....how do you really know it works?.... i certainly can not SEE the dead ticks that fall off ???!!!!. so i guess you have to TRUST what the maker tells us......and i do sorta trust Bayer ...... Although i do not use it in the very cold winter months.
Date published: 2017-03-04
Rated 5 out of 5 by from Advantage 11 Have used this for our hunting dogs and it works very well,Chewy has the best price and since we get all our Purina dry I always check Chewy first if I need dog food flea or anything relating to canine needs. Thank you for such great service.
Date published: 2017-03-04
Rated 5 out of 5 by from Good value I considered purchasing through a brick and mortar outlet, but found the pricing through Chewy was considerably less. Through Chewy the price per dose was $10.08. Whereas, at local outlet it was $14.72 including tax.
Date published: 2017-02-07
Rated 5 out of 5 by from Great product It works for my dogs. I always use this product on my cats & dogs
Date published: 2017-01-04
Rated 5 out of 5 by from Great product Work at the first aplicación, I really recommend this product
Date published: 2017-01-04
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