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K9 Advantix II Flea & Tick Treatment for Dogs Over 55-lbs

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K9 Advantix II Flea Treatment for Dogs Over 55-lbs offers broad spectrum flea control and protection against ticks and mosquitoes, too. It is specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes. K9 Advantix II also kills all life stages of fleas, repels biting flies and kills lice. It contains imidacloprid, permethrin and pyriproxyfen that work in concert to repel and kill parasites that can potentially transmit disease-causing organisms. K9 Advantix II is a flea treatment for use on dogs 7 weeks and older.

Key Benefits

  • Specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes
  • Repels and kills ticks of all types including deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks
  • Prevents fleas on treated dogs from infesting your home
  • Kills fleas on dogs within 12 hours and continues to prevent infestations for a month
  • Contains imidacloprid, permethrin and pyriproxyfen which work to repel and kill parasites that can potentially transmit disease-causing organisms


DO NOT USE ON CATS. Do not get this product in your dog's eyes, or allow your dog to ingest this product. ALWAYS read the entire product label prior to use.

Active Ingredients

  • Imidacloprid, 8.80%
  • Permethrin*, 44.00%
  • Pyriproxyfen, 0.44%
    *cis/trans ratio: max 55% (±) cis and min 45% (±) trans

See all items by K9 Advantix II

  • Item Number
  • Brand
  • Breed Size
    Large, Giant
  • Lifestage
    Puppy, Adult


Topical prevention and treatment of ticks, fleas, mosquitoes, biting flies and lice for monthly use on only dogs and puppies 7 weeks of age and older. Monthly treatments are required for optimal control and prevention of fleas and ticks. The entire contents of the K9 Advantix II tube should be applied evenly to four to six spots on the top of the back from the shoulders to the base of the tail. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin.

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Customer Reviews

Rated 4.7 out of 5 by 406 reviewers.
Rated 4 out of 5 by works fine I've used this on my dogs for the past few years. They do not get fleas, and any ticks that attach die quickly. Also seems to work against mosquitoes. The only thing I don't like about many topicals is that they tend to leave a greasy streak down the center of the back, no matter how carefully it's applied, which can last a few days. Don't apply it immediately before a show or important event. Chewy.com's price is good, and delivery is fast. Customer service is excellent. October 30, 2016
Rated 1 out of 5 by Ineffective Didn't seem to be waterproof such as the product claims. I applied the product to my dog waited 24 hours and then took him to the lake and it seemed to come right off. The fleas came back as soon as he was dry. I waited a week and then reapplied the product. This time I have kept him out of the water up to the time I am now writing this review. Which has been about a week now. The product is still not working it has made no impact on the fleas. It should also be noted that I have treated the house and the yard and the fleas are still on my dog. October 25, 2016
Rated 4 out of 5 by Appreciate the price. Glad to get this product at a good price. We have two 70-something pound dogs so saving on everything we buy for them is important. October 30, 2016
Rated 5 out of 5 by Love It Never found any ticks or fleas on my girls when using this product. Only drawback is that it tends to make them itch and they try to rub off the product by rolling around on the floor. October 27, 2016
Rated 4 out of 5 by Best OTC option to kill fleas & ticks As a Registered Veterinary Nurse for 20+ years, I have had experience using several products that promise to kill fleas and ticks. I have found that K9 Advantix is the most effective and safest product available now without requiring a veterinarian's prescription. For dogs well over 55 pounds, use 2 tubes to provide sufficient coverage. Because this product is a liquid, it's best applied along the spine at night when the dog will be sleeping to give the liquid a chance to dry before being licked or rubbed off. Takes about 30 min. to dry. It leaves an oily spot on fabrics or carpets if spilled or dog rubs against furniture or carpet so I can't give this a 5. October 13, 2016
Rated 5 out of 5 by Necessary Flea & Tick Treatment I use this product on my dog each month and it keeps him free of fleas and ticks. Great price and quick delivery. October 27, 2016
Rated 5 out of 5 by works great, and was shipped super fast!! This product works great and thank you Chewy for shipping it so fast!! Great customer service! October 25, 2016
Rated 1 out of 5 by Not sure My dog is scratching a lot more. I don't know if it is because I changed from Lamb & rice to chicken & rice Diamonds Natural large breed or because the Advantix II isn't very effective. I had been using an internal flea control. October 27, 2016
  • 2016-10-31 T06:32:31.871-05:00
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