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K9 Advantix II Flea & Tick Treatment for Small Dogs up to 4-10 lbs

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6 treatments
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K9 Advantix II Flea Treatment for Dogs offers broad spectrum flea control and protection against ticks and mosquitoes, too. It is specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes. K9 Advantix II also kills all life stages of fleas, repels biting flies and kills lice. It contains imidacloprid, permethrin and pyriproxyfen that work in concert to repel and kill parasites that can potentially transmit disease-causing organisms. K9 Advantix II is a flea treatment for use on dogs 7 weeks and older. Do not use K9 Advantix II on cats.

Key Benefits

  • Specifically formulated for dogs and comes in a convenient, monthly topical application that not only kills but also repels fleas, ticks and mosquitoes
  • Repels and kills ticks of all types including Deer ticks, American dog ticks, Brown dog ticks and Lone Star ticks
  • Prevents fleas on treated dogs from infesting your home
  • Kills fleas on dogs within 12 hours and continues to prevent infestations for a month
  • Contains imidacloprid, permethrin and pyriproxyfen which work to repel and kill parasites that can potentially transmit disease-causing organisms


Use only on dogs and puppies 7 weeks of age and older and weighing 4 to 10 pounds. DO NOT USE ON CATS. Keep out of reach of children. Do not get this product in dog's eyes or mouth. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rate, may occur after using ANY pesticide product on dogs. If signs persist, or become severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.

Active Ingredients

  • Imidacloprid 8.80%
  • Permethrin 44.00%
  • Pyriproxyfen 0.44%

See all items by K9 Advantix II

  • Item Number
  • Brand
  • Breed Size
    Extra Small
  • Lifestage
    Puppy, Adult


How to open:

  • Be sure tube is at bottom of pouch.
  • Using scissors, cut the pouch across the top and remove tube.

How to apply:

  • Use only on dogs.
  • Remove applicator tube from the package. Use scissors and peel down foil.
  • Hold applicator tube in an upright position. Pull cap off tube.
  • Turn the cap around and place other end of cap back on tube.
  • Twist cap to break seal, then remove cap from tube.
  • The dog should be standing for easy application. The entire contents of the K9 Advantix II tube should be applied evenly on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • Discard empty tube.
  • In cases of severe pest infestations, retreatment is allowable earlier than 4 weeks. Do not retreat more often than once every 7 days. After pest control is attained, return to a monthly retreatment schedule.

Frequently Asked Questions

How is K9 Advantix II different from K9 Advantix?

With the addition of an insect growth regulator (IGR), K9 Advantix II kills all life stages of fleas. K9 Advantix II also prevents development of fleas, flea eggs, larvae (maggots), and pupae (cocoons), and prevents fleas on a treated dog from infesting your home.

What is the benefit of repellency?

Repellency helps prevent ticks, fleas, and mosquitoes from attaching, biting or feeding. A repelled parasite doesn’t bite or attach. If it doesn’t bite or attach, it can’t transmit the organisms that may cause disease.

What is the difference between K9 Advantix II and other tick and flea products?

K9 Advantix II repels and kills ticks, fleas, and mosquitoes. It repels biting flies and kills lice, too. Its repellency activity and broad spectrum make K9 Advantix II different from other tick and flea products.

Is K9 Advantix II waterproof?

Yes. There is no need to reapply the product after weekly swimming or a bath. For best results, use a non-detergent shampoo.

Can I use K9 Advantix II on my cat?

No. K9 Advantix II must not be used on cats because of a cat’s unique physiology and inability to metabolize certain compounds.


Dog Weight K9 Advantix II Volume
10 pounds and under Small Dog 0.4 mL tube
11 to 20 pounds Medium Dog 1.0 mL tube
21 to 55 pounds Large Dog 2.5 mL tube
over 55 pounds Extra Large Dog 4.0 mL tube

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Customer Reviews

K9 Advantix II Flea & Tick Treatment for Small Dogs up to 4-10 lbs is rated 4.6 out of 5 by 111.
Rated 5 out of 5 by from My favorite flea and tick med! This is the only flea and tick medication I buy. I think it's the best. I like that not too long after it's on, it drys and absorbs so your dog doesn't have a greasy spot on their neck. Some of the other flea and tick medications leave that greasy spot for a day or two. My two shih tzu's are flea and tick free!
Date published: 2017-01-13
Rated 5 out of 5 by from Using for 15 Years Been using this product (and its predessor, Advantix 1), on my 15-year old Yorkie since he's 3 months old. Came highly recommended by my veterinarian, and never had a problem with it.
Date published: 2016-12-17
Rated 5 out of 5 by from Great Product This year was the first time in years I have had fleas after using a couple other brands I bought this online. This product worked great! Within a day my dogs were free from bugs. Excellent!!!
Date published: 2017-01-22
Rated 5 out of 5 by from This product is very effective! No more fleas!! I have 5 pets! Three inside dogs, one inside cat and one outside stray cat! I have ordered flea protection for all my pets and it works great!! Even the outdoor stray!! No more fleas!!
Date published: 2017-01-30
Rated 5 out of 5 by from It has flea, and mosquito repellent We have a 4 lb. Yorkie and have used this product in the past. I highly recommend it over other products. Most products don't have the mosquito repellent.
Date published: 2017-01-24
Rated 5 out of 5 by from Love my products healthy and my dog is satisfied Won't order anyplace else very satisfied with the products and overall service the customer service is very knowledgeable and perfessional my products always delivery on time
Date published: 2017-01-16
Rated 5 out of 5 by from It's the good stuff! I live in rural Louisiana, Where the ticks are known to outweigh small dogs and the state bird is the Mosquito. I have used K9 Advantix and K9 Advantix II for dogs over 55lb on both Smith and Wesson, My Kelpi dogs, for the entire ten years of our relationship. I saved Ruger, my Black&Tan Hound puppy from the dumpster where some P.O.S. abandoned him, he now gets K9 Advantix over 55lb also. My most recent purchase of this product was for Saiga, a 4lb silky terrier who was abandoned or lost alongside the highway and came running when she saw me and is still here (no one responded to flyers for a lost silky) she is about the size of some of the Ticks around here. With monthly use of K9 Advantix II, I have NO Fleas or Ticks, and I breath a lot easier knowing the product is effective against the ever present flocking hoards of Mosquitos in this area.
Date published: 2014-06-18
Rated 1 out of 5 by from No expiration date I buy this product all the time. I bought 2 boxes because price, however there is no expiration date. So i don't know how effective it will be. Each month i apply it i don't know if it will work.
Date published: 2016-12-24
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