Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports pet’s liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs

See all items by Nutramax

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Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.


For pets up to 12 lbs take 1 tablet. For pets over 12 lbs 1 tablet twice a day.

Customer Reviews

Rated 4.8 out of 5 by 96 reviewers.
Rated 5 out of 5 by this has been great for my dog !! got her liver enzymes down to a normal range !! Excellent product !! As always Chewy is the best !!! Fast delivery and always in stock !! THANKS CHEWY !!! September 26, 2016
Rated 5 out of 5 by I am believing in this product. Its going to work well for my dog. I am into the second month, on the way to the third month. After the third month, I will review my dog's reading and I am very confident that this product has done its good work to solve the problem . If I am to continue Denamarin for my dog, I will certainly do so. I be will more than happy to pass good words to other regarding this product. "Thank you Chewy' for Denamarin. September 23, 2016
Rated 5 out of 5 by Vet Recommended My older dog (13+years) is on Rimadyl for an injury induced arthritis condition. (She was a recuse) I wanted to put her on Milk Thistle to help protect her liver, but my vet recommended Denamarin. After 7 weeks her liver enzyme values were re-tested and there was definite improvement in her liver values. It is expensive, but so worth it. September 16, 2016
Rated 4 out of 5 by Never really got to use it I ordered this from the advice of my Vet. It was much cheaper then anyone else so I was happy for that. I can't say I would recommend it for my Dog only had one pill. He was very sick and did not make it past that:-(. I thought of checking to see if they would take it back since we only used one but it was already opened so I figured they would not. I have to say for future items I will check with this company first for they do seem to be cheaper. September 7, 2016
Rated 5 out of 5 by I love chewy.com I do a lot of business with chewy.com for my fur babies. Their operators are the nicest I've ever spoken with, their products are top quality at the best prices around and shipments are always quick and on time. I can't speak highly enough about chewy.com. September 10, 2016
Rated 5 out of 5 by It's Working For Our Big Guy Our big guy Charlie (8 yo Catahoula mix) has had elevated liver enzymes for several years now. He has been through multiple tests to determine if he possibly has Cushing's disease (results are still inconclusive). Our vet recommended Denamarin six weeks ago. Charlie just had his follow up checkup and his enzymes have dropped almost 150 points from the mid 500s - this is still elevated, but heading in the right direction. We'll have him retested in another six weeks. As some reviewers have mentioned, this product is recommended to be taken on an empty stomach; however, after speaking with our vet, this is only because the medicine is better absorbed that way. It can also be given up to two hours after mealtime and should be absorbed as well. No harm should be done if these times are not met - the medicine just won't be absorbed as well as if on an empty stomach. Charlie gets his pill in a little almond butter when I wake up in the morning, and this doesn't seem to have negatively affected him in any way (other than he expects his 'treat' as soon as I wake up). June 7, 2016
Rated 5 out of 5 by On time and slightly lower priced My dog has Copper Storage Birth Defect and she is on a daily maintanence including Denamarin. The auto ship makes this cheaper and easier than searching quarterly to find the cheapest price. September 8, 2016
Rated 4 out of 5 by Vet Recommended Our dog's oncologist recommended this product to offset the effects of the chemo Arrow is receiving for her lymphoma. To be most effective, the medicine should be administered on an empty stomach. Normally not finicky, Arrow did not like the chewable tablets and she doesn't really care for the other pills either. So we disguise them in thinly sliced deli meat. Then we don't feed her for another hour. It's difficult to tell if they're working, but we give them to her anyway. August 25, 2016
  • 2016-09-30 T06:47:32.416-05:00
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