Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases glutathione, an important compound for liver health
  • Help protect liver cells from cell death
  • Help to repair and regenerate cells

See all items by Nutramax

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Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.


For pets up to 12 lbs take 1 tablet. For pets over 12 lbs 1 tablet twice a day.

Customer Reviews

Rated 4.8 out of 5 by 88 reviewers.
Rated 5 out of 5 by It's Working For Our Big Guy Our big guy Charlie (8 yo Catahoula mix) has had elevated liver enzymes for several years now. He has been through multiple tests to determine if he possibly has Cushing's disease (results are still inconclusive). Our vet recommended Denamarin six weeks ago. Charlie just had his follow up checkup and his enzymes have dropped almost 150 points from the mid 500s - this is still elevated, but heading in the right direction. We'll have him retested in another six weeks. As some reviewers have mentioned, this product is recommended to be taken on an empty stomach; however, after speaking with our vet, this is only because the medicine is better absorbed that way. It can also be given up to two hours after mealtime and should be absorbed as well. No harm should be done if these times are not met - the medicine just won't be absorbed as well as if on an empty stomach. Charlie gets his pill in a little almond butter when I wake up in the morning, and this doesn't seem to have negatively affected him in any way (other than he expects his 'treat' as soon as I wake up). June 7, 2016
Rated 5 out of 5 by Really works Our husky has liver problems that makes her liver enzymes very high even on a no fat diet! We started her on Nutramax Denamarin tablets and within a month her enzymes dropped by 400 points!!! She is not in the normal range yet but her numbers are headed that way!! She is doing much better!! August 20, 2016
Rated 5 out of 5 by saved our dog Our "middle furry child " had liver enzymes of 1200 from unknown toxins-- she received fluids and at the hands of our wonderful veterinarians , survived. She has been on Denamarin for several months-and after our latest blood work last week-enzymes are at 125-- she will be on them for life, which I hope are many more years from now-she is 13. August 21, 2016
Rated 5 out of 5 by Great price!!! This product is very important for my aging dog with all the meds he is on to balance out his liver enzymes. August 22, 2016
Rated 5 out of 5 by Denamarin is a good product for the liver This product works well, just be sure to give at least a hour before eating. Chewy delivery this product very quickly. August 21, 2016
Rated 5 out of 5 by Denamarin for dogs Vet recommended for our dog. She has had excellent results and has been on it a long time. August 14, 2016
Rated 5 out of 5 by Great for Liver Health Our black lab developed hepatitis and our vet started her on this - within two weeks she was responding. She is now back to baseline and symptoms of hepatitis are gone. She went from not eating to eating again. She is on her second month of taking this and depending on what our vet recommends I may continue it for her. It is a great vitamin for liver health. Great price too! August 9, 2016
Rated 4 out of 5 by Good price for product Chronic pancreatitis dog, needs the denamarin....I assume it helps him, but won't know for sure til we get another blood check. Chewy.com price is much lower than in my vets office, and it arrives in one or two days- great customer service. August 4, 2016
  • 2016-08-26 T09:59:17.204-05:00
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