Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports pet’s liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs


Store in a cool, dry area. Keep out of reach of children.

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  • Item Number
  • Brand
  • Breed Size
    Medium Breeds, Large Breeds, Giant Breeds
  • Lifestage
  • Made in
    United States
  • Supplement Form

Nutritional Info


Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.

Feeding Instructions

Weight Daily Feeding
35-65 lbs 1 tablet
66-120 lbs 2 tablets
Over 120 lbs 3 tablets

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About Nutramax Dog Supplements

About Nutramax Dog Supplements

Made to Support Your Dog's Well-Being

Nutramax makes unique supplements that are formulated specifically for dogs to keep them in their best health. These high-quality supplements help support your pup's general wellness with easy-to-administer tablets, soft gel caps, soft chews, sprinkle capsules and liquids that are made for joint, liver, digestive, and skin and coat health. Nutramax canine wellness products help your dog stay young at heart so he can keep playing and living life to the fullest for years to come.

Maintaining Liver Health

Nutramax offers three options for liver support—Denosyl, Denamarin and Marin Plus. SAMe, the active ingredient in both Denosyl and Denamarin, has been shown to help protect liver cells, and may help repair and regenerate them. Aside from keeping the liver healthy, SAMe offers support for cognitive function. Denamarin also contains Silybin to maintain a healthy oxidative balance in this important organ. In Marin Plus, five key ingredients go to work to maintain liver function, including Silybin, vitamin E, zinc, medium chain triglyceride and curcumin extract. Marin Plus provides antioxidants and an energy source for the liver and helps it to absorb nutrients from your dog’s food.

Restoring Balance With Proviable

Whether your pup has a temporary case of upset stomach from travel or boarding stress, antibiotics, trying a new food or just having a sensitive system, Proviable helps put things back in balance.

Nutramax Proviable Kits for short-term support

Nutramax Proviable Kits for short-term support: Each comes with Proviable-KP paste with probiotics, prebiotics and stool-firming ingredients, plus Proviable-DC capsules that provide continued intestinal support.

Nutramax Proviable - DC for long-term support

Nutramax Proviable - DC for long-term support: These capsules offer natural support with seven key probiotics and two prebiotics to help get the digestive system back on track.

Skin and Coat Care

Skin and Coat Care

Nutramax Welactin Canine contains high-potency fish oil with substantial amounts of EPA and DHA, two omega-3 fatty acids responsible for skin and coat health. These important omegas not only help combat dry skin, but they also support the kidneys, brain and vision health, and a strong immune system. Many pet parents see improvement in their dog's appetite, alertness and overall appearance when they try Welactin.

De-Stress Your Dog With Cosequin Calm

If your pup tends to get anxious when guests come to visit or during thunderstorms, or even when there's construction going on nearby, Cosequin Calm can give him relief. It comes in a form that's easy to give to dogs—a delicious, chewable bone-shaped tablet with natural flavor. The proprietary formula includes extracts of medicinal plants to help ease stress, and L-theanine, an amino acid that's been shown to reduce anxiety. You can use Cosequin Calm daily or before stressful events to help your dog relax.

De-Stress Your Dog With Cosequin Calm

About Nutramax

The philosophy behind every Nutramax product is that wellness is not just a feeling, but a mindset. With this in mind, they've created supplements for dogs, cats and horses that meet their unique needs for whole-body health. They believe in products that are backed by science, which is why they test the efficacy of each ingredient they use in their own state-of-the-art research facilities. Nutramax's powerful formulations are safe for pets yet effective in helping to maintain digestive, joint, brain, skin and coat, gastrointestinal, urinary, liver and behavioral health.

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About Nutramax

Customer Reviews

170 reviews 170 Reviews 4.8 out of 5 Stars

98% Recommend

98% of reviewersrecommend this product

4.8 / 5
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  • Very helpful product

    By on

    We have been giving this product to our dog because she is receiving chemotherapy and the veterinarian wants her to take it to protect her liver. So far it is helping her. The only drawback is that it has to be taken on an empty stomach 1 hour before a meal, and not with food, just with water. We have been giving it to her with a little food.

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  • Denamarin for Hatchi

    By on

    I had to order these for my dog, he has liver disease. The meds really help him. Also I have heard a lot of people talking about chewy. Every thing they have said has being true. After my first order I was hooked so I ordered again. Chewy is where I will get all my dogs supplies from now on. All my family and friends have dogs and horses so I will let them know about you guys. We will all bring a lot of business to chewy.com Thanks again Erin

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  • So far so good

    By on

    I haven't gotten recheck liver bloodwork done yet but so far no ill effects; I will update in 5 weeks. 14 y/o pit bull taken to support liver function and reduce liver enzymes. As of 9/25/17 she has started her 4th week on this product (Denamarin). Must be given on an empty stomach for best results according to the directions. Thats sort of a pain but so far so good as I've said just had to change feeding schedules a bit.

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  • Best thing since milkbones!

    By on

    I have been ordering from Chewy for over a year now for 3 dogs, 2 cats and a myriad of tropical fish. Chewy is unsurpassed in service, accountability and efficiency. My orders are ALWAYS prompt, timely and accurate. I have absolutely no complaints about the service or products I receive. On the occasions that I have needed to contact Chewy resources either by phone or internet I have received courteous, professional assistance and my questions or requests have been addressed by knowledgeable and courteous staff. A great company to do business with!

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  • You get what you paid for

    By on

    This supplement, in conjunction with my dogs other medications have significantly helped her liver functions and blood levels. However, these costs add up quickly and I wish there was some type of assistance program for this vital medication or even a rewards program.

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    By on

    I've been giving this medicine to my 14 year old dog, because the vet said he needed it for his liver, for about 6 months now. I don't know what Dusty thinks because he can't talk and I haven't had a blood test recently, but I do know Dusty is still kicking. Chewy was the best price I've received, because of the coupon I was sent.

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  • It helped to heal my dogs liver

    By on

    My dog Aldo got very sick after he was exposed to poison (due to some evil neighbors). After vomiting all night we rushed him to the vet in the morning and his liver (ALT) levels were 872 (normal is 10-125). Our vet recommended Nutramax Denamarin but it was not available there. We ordered it on chewy.com and received it in 2 days. We used it for about a month and Aldo's liver levels were normal again (125) on the last vet visit. This medicine is absolutely worth the money and it saved our dog. We are so grateful.

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  • Working so far

    By on

    My dog was having trouble holding his bladder and was peeing on the floor. We took him to vet and he was diagnosed with liver disease. The vet told us to put him on Denamarin for treatment. Since he's been on his medication he has quit peeing on the floor and has gotten more active. He's been on it for about six weeks and we've noticed a big difference in his health and him being active.

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  • Liver supplement

    By on

    My dog has an issue where her liver enzymes rise and all tests came back negative. The doctor is not sure why it's rising, but this seems to keep them down and even when they rise, they don't rise as fast as they normally would have. It's a once a day pill. You give it to them in the morning, wait 1 hr and then feed as normal. The pill MUST be given on an empty stomach to make it work at its best. You can wait 4 hrs after you feed them and make sure their stomach is empty and then give it to them. It's a large pill, so I suggest Liverwurst with the pill as my vet suggested this :D

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  • U can teach an old dog (13) new tricks w/Denamarin!!

    By on

    The headline says it all. The trick for me is figuring out how to administer the pill on an empty stomach. Pit Bulls don't like "empty stomachs" and bark incessantly when it's the normal feeding and/or treat time. But it's all worth the outcome.

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