Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases glutathione, an important compound for liver health
  • Help protect liver cells from cell death
  • Help to repair and regenerate cells

See all items by Nutramax

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Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.


For pets up to 12 lbs take 1 tablet. For pets over 12 lbs 1 tablet twice a day.

Customer Reviews

Rated 4.8 out of 5 by 77 reviewers.
Rated 5 out of 5 by It's Working For Our Big Guy Our big guy Charlie (8 yo Catahoula mix) has had elevated liver enzymes for several years now. He has been through multiple tests to determine if he possibly has Cushing's disease (results are still inconclusive). Our vet recommended Denamarin six weeks ago. Charlie just had his follow up checkup and his enzymes have dropped almost 150 points from the mid 500s - this is still elevated, but heading in the right direction. We'll have him retested in another six weeks. As some reviewers have mentioned, this product is recommended to be taken on an empty stomach; however, after speaking with our vet, this is only because the medicine is better absorbed that way. It can also be given up to two hours after mealtime and should be absorbed as well. No harm should be done if these times are not met - the medicine just won't be absorbed as well as if on an empty stomach. Charlie gets his pill in a little almond butter when I wake up in the morning, and this doesn't seem to have negatively affected him in any way (other than he expects his 'treat' as soon as I wake up). June 7, 2016
Rated 4 out of 5 by Good Value Was recommended by my vet for a period of time. I save $17 on this supplement compared to what my vet charged. It remains to be seen whether this helped my dog. July 19, 2016
Rated 5 out of 5 by the product was just fine. it was the first time I have ordered from Chewy and I will do it again. free shipping and fast. thx July 18, 2016
Rated 5 out of 5 by This .com can't be beat for our furry friends! Our dog was prescribed Denamarin and Chewy.com carried the same thing! Chewy delivers it right to my door and keep tabs on how often to send it!!! It has dog food, treats and toys. Best of all is the scripture verse from Proverbs about animals. Customer Service is available around the clock. I recommend it. June 29, 2016
Rated 5 out of 5 by Good product, great price Started our lab on this at the recommendation of her oncologist, when her liver enzymes began to rise. Enzymes back down and Chewy's price beats the oncologists price, so we win two ways! June 20, 2016
Rated 5 out of 5 by Denamarin for Our Olde English Bulldogge These tablets were recommended by our vet for our dog that is having liver issues, to help the liver rebuild. Your cost is less than at our vet, so we will continue to buy them through you. The delivery was quick, too! May 30, 2016
Rated 2 out of 5 by Must be taken on an empty stomach. Not easy for an older dog. My dog is 13 1/2 and takes many supplements. She can't use Pill Pockets because she is on a prescription fat restricted diet so I've started mixing her powdered supplements into her food. Desamarin presents a real problem because it is supposed to be taken on an empty stomach. I can't say how it works as I only used it once and that time in food. I don't want a tussle with my dog every morning over swallowing a supplement. May 15, 2016
Rated 5 out of 5 by WORKS WELL! Chewy.com saves me tons of money by me going direct instead of thru my vet. Plus the convenience of it shipping to me each month is wonderful because we all know time is money!!!!!!!!!!!!!!!!! LOVING THIS WEBSITE AND THE PRODUCTS WE ARE GETTING!!! My dog had high liver enzymes and this product has efficiently done the trick! May 23, 2016
  • 2016-07-24 T13:00:39.205-05:00
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