Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports pet’s liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs


Store in a cool, dry area. Keep out of reach of children.

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Nutritional Info


  1. Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.

Feeding Instructions

For pets up to 12 lbs take 1 tablet. For pets over 12 lbs 1 tablet twice a day.

Weight Daily Feeding
35-65 lbs 1 tablet
66-120 lbs 2 tablets
Over 120 lbs 3 tablets

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Two Benefits, One Incredible Supplement

Denamarin is a premium supplement for dogs and cats that packs a one, two punch — supporting both the liver and the brain. It's specially important for use with dogs and cats that have compromised liver function, regardless of cause.

Nutramax Denamarin Liver and Brain Premium Supplement
Liver Function Support

Liver Function Support

Denamarin contains S-Adenosylmethionine, a naturally occurring compound that has been shown to greatly increase levels of glutathione in the liver and repair and regenerate liver cells. It also contains silybin, which is shown to support liver function by helping to maintain healthy oxidative balance.

Brain Health Support

The S-Adenosylmethionine contained in Denamarin has also been shown to help with brain health, acting as a neuroprotector. And silybin helps to support oxidative balance in the brain for overall cognitive health.

Brain Health Support

About Nutramax Laboratories

Nutramax Laboratories has been researching and developing products for people and their pets since 1992. In that time they've become an industry leader, setting the bar for manufacturing and quality control, and creating products that make lives better — human and animal alike.

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About Nutramax

Customer Reviews

Nutramax Denamarin Tablets for Large Dogs is rated 4.8 out of 5 by 122.
Rated 5 out of 5 by from Denamarin seems to help my dog's liver I have used Denamarin for several years on several of my dogs. When they are on medication and through blood tests it appears that the medication is affecting their liver, I start giving them Denamarin once a day at least one hour before they eat breakfast. Usually one month later they get another blood test and their liver appears to have improved. One of my dogs had their liver values through the roof and after 4 months of taking Denamarin everyday, his liver values went back to normal. I would recommend Denamarin to anyone who wants to help their dog's liver health. If you have a large dog, it might seem a bit pricey for a month supply, but it is well worth it.
Date published: 2017-01-28
Rated 5 out of 5 by from GREAT PRODUCT HELPING MY BEST FRIEND My 7 year old Terrier Mix dog was diagnosed with high Alt Phos Liver Enzyme this year. She has been on this consistently and definitely has lowered her high levels or controlled them so they don't go up. She has no symptoms of anything and we've tried everything and under watch with 3 top Veterinarian specialists. This product has definitely helped her. She'll probably be on it long term Dr. said. I noticed if I give it to her at 10PM at least 3 1/2 hours AFTER she had her dinner, the next morning she has a bunch of energy and runs around like a puppy again. We've been walking/running for almost mile and a half at 6 AM. She would never get up that early... until now. Now she wakes me up and says "let's go!." I have my best friend back! Thanks Chewy & Denamarin!
Date published: 2016-12-08
Rated 5 out of 5 by from Worked great for my dog My vet recommended this product because of the results of my 12 yr old black lab/golden retriever's liver enzymes test. After taking this product for two weeks his levels improved. The pills are large and I find my dog does better if I cut the pill in half and give it to him in two small pieces.
Date published: 2017-02-08
Rated 5 out of 5 by from Thisproduct has been very beneficial for my girl. I have been using this product for almost a year due to my girl being on prednisone due to a skin disease and it has helped with her liver counts. I was buying it through my vet until I found it a lot cheaper on Chewy! I Love Chewy!!
Date published: 2017-02-15
Rated 5 out of 5 by from VERY FAST SHIPPING AND GREAT PRICE I'm a big fan of Chewy after one purchase. The shipping was extremely fast and the price was 1/4 of what the vet wanted to charge! I will definitely be buying again from Chewy.
Date published: 2016-12-26
Rated 5 out of 5 by from this is what we need for my roxie's elevated liver levels as per elevated liver levels for a senior dog with arthritic conditions, the veterinarian suggested we may need milk thistle to lower her elevated liver levels.
Date published: 2017-02-11
Rated 5 out of 5 by from Better price here than at the vet My 12 year old lab needs this expensive medication everyday. Chewy's price is well below our vets.
Date published: 2017-01-24
Rated 5 out of 5 by from It's Working For Our Big Guy Our big guy Charlie (8 yo Catahoula mix) has had elevated liver enzymes for several years now. He has been through multiple tests to determine if he possibly has Cushing's disease (results are still inconclusive). Our vet recommended Denamarin six weeks ago. Charlie just had his follow up checkup and his enzymes have dropped almost 150 points from the mid 500s - this is still elevated, but heading in the right direction. We'll have him retested in another six weeks. As some reviewers have mentioned, this product is recommended to be taken on an empty stomach; however, after speaking with our vet, this is only because the medicine is better absorbed that way. It can also be given up to two hours after mealtime and should be absorbed as well. No harm should be done if these times are not met - the medicine just won't be absorbed as well as if on an empty stomach. Charlie gets his pill in a little almond butter when I wake up in the morning, and this doesn't seem to have negatively affected him in any way (other than he expects his 'treat' as soon as I wake up).
Date published: 2016-06-07
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