Nutramax Denamarin Tablets for Large Dogs, 30 count

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When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

While best known for supporting the liver in dogs, Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Key Benefits

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports pet’s liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs


Store in a cool, dry area. Keep out of reach of children.

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Nutritional Info


  1. Contains 425 mg of S-Adenosylmethionine and 35 mg of Silybin A+B.

Feeding Instructions

For pets up to 12 lbs take 1 tablet. For pets over 12 lbs 1 tablet twice a day.

Weight Daily Feeding
35-65 lbs 1 tablet
66-120 lbs 2 tablets
Over 120 lbs 3 tablets

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Two Benefits, One Incredible Supplement

Denamarin is a premium supplement for dogs and cats that packs a one, two punch — supporting both the liver and the brain. It's specially important for use with dogs and cats that have compromised liver function, regardless of cause.

Nutramax Denamarin Liver and Brain Premium Supplement
Liver Function Support

Liver Function Support

Denamarin contains S-Adenosylmethionine, a naturally occurring compound that has been shown to greatly increase levels of glutathione in the liver and repair and regenerate liver cells. It also contains silybin, which is shown to support liver function by helping to maintain healthy oxidative balance.

Brain Health Support

The S-Adenosylmethionine contained in Denamarin has also been shown to help with brain health, acting as a neuroprotector. And silybin helps to support oxidative balance in the brain for overall cognitive health.

Brain Health Support

About Nutramax Laboratories

Nutramax Laboratories has been researching and developing products for people and their pets since 1992. In that time they've become an industry leader, setting the bar for manufacturing and quality control, and creating products that make lives better — human and animal alike.

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About Nutramax

Customer Reviews

Rated 4.8 out of 5 by 112 reviewers.
Rated 5 out of 5 by Reasonable price and fast shipping My Basset Hound has been on Denamarin for a few months now to treat high liver enzymes. His liver enzymes rocketed when he was on medication for Valley Fever but have been coming down steadily after being on this supplement. He is a very good boy about taking his meds, I just plopped them down the back of his throat since this must be taken on an empty stomach. I used to work for a vet clinic and the price I got it for on here was better, even with all the discounts I got at the clinic. Also, I give this supplement in the evening, an hour before his meal. I find it easier for me to give in the PM so I don't have to worry about waiting an hour to feed in the morning when I need to be somewhere. However, that schedule works for me and my dude dog but discuss with your vet what may be best for your pup. December 19, 2016
Rated 5 out of 5 by GREAT PRODUCT HELPING MY BEST FRIEND My 7 year old Terrier Mix dog was diagnosed with high Alt Phos Liver Enzyme this year. She has been on this consistently and definitely has lowered her high levels or controlled them so they don't go up. She has no symptoms of anything and we've tried everything and under watch with 3 top Veterinarian specialists. This product has definitely helped her. She'll probably be on it long term Dr. said. I noticed if I give it to her at 10PM at least 3 1/2 hours AFTER she had her dinner, the next morning she has a bunch of energy and runs around like a puppy again. We've been walking/running for almost mile and a half at 6 AM. She would never get up that early... until now. Now she wakes me up and says "let's go!." I have my best friend back! Thanks Chewy & Denamarin! December 8, 2016
Rated 5 out of 5 by Helpful Arrived quickly and price was good. Would order again. January 3, 2017
Rated 5 out of 5 by VERY FAST SHIPPING AND GREAT PRICE I'm a big fan of Chewy after one purchase. The shipping was extremely fast and the price was 1/4 of what the vet wanted to charge! I will definitely be buying again from Chewy. December 26, 2016
Rated 5 out of 5 by Vet prescription helps my dog. Vet prescribed this med for my dog, whose liver enzymes counts are above the normal range. The cost for a 30 day supply from chewy.com is $30.00 less expensive, then getting meds from vet. Since taking these meds, her energy level has increased. December 18, 2016
Rated 5 out of 5 by Happy with the results The vet recommended this supplement because my dog is on a long term use & dose of prednisone which was showing some effect on his liver & kidney function. After 2 mos of Denamarin (1 tab daily), his blood work showed "no change" which is I am pleased with since it seems to be stabilizing him. December 14, 2016
Rated 4 out of 5 by Denamarin Tablets I'm sure these supplements will help but I wish they could come in chewable form. My dog and I don't like shoving pills down her throat. December 14, 2016
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