Endurosyn Canine Digestive Oral Gel for Dogs

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Endurosyn Canine Oral Gel is a unique, patented oral nutritional supplement formulated with amino acids, electrolytes, vitamins, fatty acids and lactic acid bacteria to support your dog’s immune system, digestive system and overall health. When given as directed, this palatable gel helps maintain energy and well-being. It also provides a healthy electrolyte and microbial balance in your dog’s digestive system during stressful situations like trips to the vet or training sessions.

Key Benefits
  • Unique, patented palatable oral gel supplement containing amino acids, electrolytes, vitamins, fatty acids, and lactic acid bacteria
  • Helps maintain energy and electrolyte balance in active dogs
  • Lactic acid bacteria supports a normal digestive system
  • Great to use during times of stress, including traveling, kenneling or training
  • Easy to dose gel is delicious and full of nutrients that your active dog - or any dog - needs to support their immune system, digestive system or overall health.

For animal use only. Keep out of the reach of children.

See all items by Endurosyn

  • Item Number
  • Brand
  • Lifestage
    Adult, Senior, Puppy
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Food Form
  • Product Form
Nutritional Info

Sodium Chloride, Glutamine, Glycine, Potassium Chloride, Sucrose, Corn Starch, Soy Oil, Vitamin A Acetate, Vitamin D3 Supplement, Vitamin E Supplement, Ascorbic Acid, Riboflavin, Coconut Oil (Source of Fatty Acids), Inulin, Dried Lactobacillus Acidophilus Fermentation Product, Dried Enterococcus Faecium Fermentation Product, Dried Lactobacillus Plantarum Fermentation Product, Dried Lactobacillus Casei Fermentation Product, Dried Poultry Liver, Silicon Dioxide, Polysorbate Bo, Mixed Tocopherols (a Preservative).

Feeding Instructions
WeightDaily Feeding (grams)
Up to 70 lbs10
70+ lbs20

Treat for 3 days or as directed by your veterinarian. Provide access to fresh drinking water at all times.

Store at room temperature.


When do I use Endurosyn Canine Oral Gel versus Lactoquil?

Endurosyn is a 3-day probiotic oral gel for short-term use in support of digestive health during times of stress or transition. Pets that suffer from GI upset when boarding, traveling, training, or going to the vet are good candidates for Endurosyn.

Lactoquil is a daily probiotic soft chew specially formulated to assist in ongoing digestive health maintenance for dogs. If your dog has a history of a sensitive stomach or seems to suffer from on and off again GI upset, talk to your veterinarian to determine if your dog would be a good candidate for Lactoquil.

Warnings: Keep out of reach of children. For animal use only.

What is the difference between Endurosyn Canine Oral Gel and Lactoquil?

Endurosyn is designed for use during short stints of stress or transition (traveling, kenneling, etc.) that can cause GI upset. It contains probiotics and additional ingredients such as electrolytes, vitamins and concentrated energy sources to help support the protective layers of the bowel, as well as maintain proper intestinal pH.

Lactoquil is a daily probiotic soft chew to be used for ongoing digestive health support for dogs only. It contains high levels of live, viable naturally occurring beneficial bacteria (like some yogurts) to assist in healthy digestion and absorption.

Can I use Endurosyn Canine Oral Gel and Lactoquil together?

There are no known contraindications, but always tell your veterinarian about all the medications and supplements that you give your dog.

What could cause my pet's normal gastrointestinal (GI) system to be disrupted?

A normal GI system has a healthy balance of microorganisms, but your pet's system can be disrupted by:

  • Dietary changes or indiscretions
  • Stress from boarding, travel or hospitalization
  • Antibiotic therapy
  • Deworming
  • Age
  • Food sensitivities

Endurosyn Canine Oral Gel contains Caprylic Acid. What is this ingredient?

Caprylic Acid is a medium-chain triglyceride (MCT) found in coconut oil. MCT's provide nourishment and energy to cells lining the GI tract. Endurosyn also provides electrolytes and amino acids to support and nourish cells along the intestine.

Can I use Endurosyn Canine Oral Gel on my cat?

No. Endurosyn Canine Oral Gel is labeled for use in dogs only. Endurosyn Feline Oral Gel should be used for cats.

Why does Endurosyn Canine Oral Gel contain several strains of bacteria?

The GI tract has a complex, intermixing array of beneficial bacteria, called the microflora. It is maintained in a careful balance that coats and protects the layers of the intestines. Under certain conditions, gaps or breaks in the microflora appear, creating opportunities for microbial imbalances to occur. This often leads to GI upset and distress. A probiotic with multi-strains of bacteria is able to utilize the strengths of each specific strain to promote proper gut flora balance.

How should Endurosyn Canine Oral Gel be stored?

Store at room temperature in a location your dog can't access. It does not require refrigeration or any other special storage.

When should Endurosyn Canine Oral Gel be given?

Endurosyn can be given at any time. Provide fresh water at all times.

WeightFeeding Recommendations
Puppies and Dogs under 70 lbs10 grams daily (5 grams twice a day) for 3 days or as directed by your veterinarian.
Dogs 70 lbs or more20 grams daily (10 grams twice a day) for 3 days or as directed by your veterinarian.

Can I give my dog more than the recommended amount?

No. Please follow the feeding recommendations as listed on the product label.

What is the protein source in Endurosyn Canine Oral Gel (flavor)?

Poultry liver.

Endurosyn is not intended for patients with known hypersensitivity to any of the ingredients in the product.

What is the National Animal Supplement Council (NASC)?

The National Animal Supplement Council is a nonprofit industry group dedicated to protecting and enhancing the health of companion animals throughout the U.S. The overriding goal of the NASC is to promote the health and well-being of cats and dogs that are given animal health supplements by their owners, and to protect and enhance the integrity of the animal health product industry.

Look for the NASC Quality Seal on Endurosyn and all Bayer supplements.

What is the National Animal Supplement Council (NASC) Quality Seal found on Endurosyn Canine Oral Gel and all Bayer supplements?

The NASC Quality Seal program was initiated as part of the NASC's ongoing effort to improve and standardize the animal supplement industry.

The Quality Seal is a way for consumers to know the product they are buying comes from a manufacturer that voluntarily complies with standards set forth by NASC.

NASC member companies must comply with rigorous requirements before they are granted permission to display the seal:

When you see the Quality Seal on a product, you can trust it comes from a reputable company that has successfully passed an independent quality audit.

Look for the NASC Quality Seal on Endurosyn and all Bayer supplements.

Why should I include vitamins & supplements in my pet's diet?

Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet's exact health needs. Like in humans, vitamins and supplements can help support your pet's long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.

How often should I give this supplement to my pet?

It is recommended to give the suggested dosage based off your pet's weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.

Is this supplement safe to use with the medication my pet is currently taking?

If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.

My pet is allergic to certain ingredients, will this product be safe to use?

For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.

Does this product come in other product forms?

For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.

About Endurosyn

Experience the Benefits of Endurosyn

Experience the Benefits of Endurosyn

Life is full of disruptions, and even little changes can throw your pup’s digestive system off balance. Endurosyn was formulated to restore that balance naturally, without drugs or interventions. Help your bud get back on track so he can live his best life!

What is Endurosyn?

Endurosyn is a three-day oral probiotic gel for dogs. It helps repopulate the gut with the natural microorganisms it needs for good digestion and overall health. Recommended for any time your dog undergoes stress.

Support During Times of Stress

Endurosyn can help any time your fur-buddies are dealing with physical or environmental pressures that can wipe out gut bacteria. It can aid pups with dietary issues like food sensitivity and upset stomach—or when your buddy eats something he shouldn’t! This powerful probiotic blend also makes things better after antibiotic therapy or deworming and is recommended after travel, kenneling and training, too.

What's In Endurosyn


At least 10 million colony-forming units of live lactic acid bacteria per dose.


Support beneficial probiotic bacteria so they can thrive and repopulate after disruptions.


Help the GI tract absorb water for proper digestion.


Support cell health in the intestines.

Bayer Supplement Brands




Free Form™

Free Form™


Key Ingredients

Joint Health

Healthy Aging

General Wellness

General Wellness

GI Support


A daily soft chew that provides ongoing mobility and joint support.

A daily soft chew for dogs that promotes joint health and helps maintain comfort throughout the body as dogs age.

Omega-3 fatty acids that support sensitive skin, eye, joint, brain, heart, kidney and immune health.

Omega-3 fatty acids that support sensitive skin, eye, joint, brain, heart, kidney and immune health.

A daily probiotic soft chew for dogs. Offers ongoing digestive health support.

What Is It?

Glucosamine, green-lipped mussel, Boswellia, turmeric

Baicalin, catechin, Boswellia

Fish oil (anchovies)

Fish oil (anchovies)

Probiotic (live microbes), prebiotic (inulin)


Soft chew

Soft chew

Gel Cap


Soft chew

Count Size







60, 120, 240

60, 90

60, 250

4 oz. liquid


About Bayer

Bayer has been working to make the lives of pets better for over a century, with innovative, science-based solutions that help them stay healthy and strong. They offer a full line of supplements designed specifically for our furry friends, to help them live their longest and happiest lives right by our side.

Shop Bayer

Rating: 4.5 of 5 stars 12 Reviews 12 Reviews 4.6 out of 5 Stars

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92% Recommend

92% of reviewersrecommend this product

Rating: 4.5 of 5 stars 4.6 / 5

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12 Reviews

Showing 1-10 of 12 Reviews

  • 5 out of 5 stars

    Dog loves this

    By Cathyb on Jan 11, 2021

    We have a mini poodle with sensitive stomach. She is also a picky eater. She loves this probiotic. Gobbles it up and it really helps her loose stools. We give it to her when we travel or if we see her tummy issues flaring up. Works really well.

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  • 5 out of 5 stars

    product that actually works

    By Tiko on Feb 3, 2021

    This Gel works great for My GSD who has very sensitive stomach! Giving him as directed changed our life! Definitely ordering more to have supply in his pantry

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  • 5 out of 5 stars

    Miracle for Upset Tummies!

    By Blukitty on Sep 17, 2020

    My vet has prescribed this for my senior poodle to help with upset and vomiting. It helps to get her system back to healthy functioning. ! It has the consistency of jam and I can easily get her to take it by using a small spoon & putting it on her tongue. Really happy to see I can order from Chewy and save a trip to the vet to get it

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  • 5 out of 5 stars

    Love this stuff!

    By MWolter on Dec 10, 2018

    I always keep a tube of Endurosyn around the house. It works like a charm whenever one of my pups breaks with diarrhea. Its super palatable and is readily accepted (even by my oldest little guy who has kidney disease).

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  • 1 out of 5 stars

    Never again.

    By Dinah on Mar 3, 2019

    I purchased this from my vet for my dog with IBD. A total disappointment.

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  • 5 out of 5 stars

    Great product

    By Jackson123 on Jul 19, 2018

    It was delivered in a very timely manner would definitely buy this product again have never had a problem with this website , Definitely great products

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  • 5 out of 5 stars

    Very Helpful

    By Mydogz2 on Apr 18, 2018

    Used this for my corgi after a bout of severe diarrhea. It was recommended by my vet to restore digestive balance. It works fast, and really well. Dog likes the taste, so it is easy to administer.

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  • 5 out of 5 stars

    Great product and price

    By Pkay on Feb 27, 2018

    My vet sent my dog home on this but for the price of 34,99. Told them thanks but I’ll try Chewy. Less than half the price and same great product for diarrhea .

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  • 5 out of 5 stars

    Excellent Product

    By Cher on Oct 25, 2017

    My Dog Had Bad Diarrhea For a Few Days. ordered some Endurosyn canine digestive oral gel, after giving it to my dog the second day my dog was so much better, This Endurosynis is the best..Chewy is The Best Very Fast Shipping..This Price is Great, My Vet Cost Was $40.00 Thanks Chewy

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  • 5 out of 5 stars

    Not sure if it works

    By NewPuppy on May 10, 2017

    My vet was going to send me home with this product at $24.95 price so I declined and checked the price here on Chewy.com when I got home. It was way cheaper here. I gave it to my puppy but she had gotten metronidazole for 10 days before I gave this product to her so I'm not sure if it really works. She loves it though.

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