Epizyme Powder for Dogs & Cats

By Epizyme
Rated 4.8571 out of 5 stars
Prescription Item
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Epizyme Powder for Dogs & Cats, 8-oz slide 1 of 5
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$69.99Chewy Price
$66.49Autoship Price
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About This Item

Epizyme is a prescription powder that acts as a digestive aid. This medication is most commonly used in those who are not able to properly digest food due to the lack of digestive enzymes created by the pancreas—a condition known as exocrine pancreatic insufficiency (EPI). Epizyme helps to improve the digestion of proteins, carbohydrates and fats, while also helping your pet get to a healthy weight.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Epizyme From Our Team of Experts
Learn More About Epizyme From Our Team of Experts

ReviewsWrite a Review

Rated 4.8571 out of 5 stars
7 Reviews
Would recommend to a friend

7 Customer Reviews

Rated 5 out of 5 stars
By Silvia on Jun 25, 2022


Works great. My dog needs to be on this for live, started 3 weeks ago. Oh what a different. Works wonders

Rated 5 out of 5 stars
By Tofteetay on Feb 23, 2022

Fast results!

My German shepherd developed EPI and the vet recommended this product. I immediately saw results as far as his weight gain. He had previously lost over 10 pounds and he quickly regained weight back. His poops started being solid after a couple of weeks using the product. This stuff really saved his life!

Rated 5 out of 5 stars
By Higgins on Mar 24, 2022

Great Product

We have a dog with EPI. His pancreas does not produce the enzymes necessary to digest food. Without this enzyme, he would lose weight to the point that he would eventually die of malnutrition.

Rated 5 out of 5 stars
By sarah on Aug 19, 2021


My German Shepherd developed an EPI and my vet recommended this. He gained back 20lbs within 6 months. He is so much healthier now.

Rated 5 out of 5 stars
By Karen on Apr 23, 2021

Works as well as the others

Epizyme works as well as the other enzymes I tried. It is half the price of what the other enzymes were that I used at first. All the enzymes are expensive, but all the ones I've tried have worked for my dog with EPI. I use a little less than a teaspoon. It's still pricey when you think the dog has to be on it the rest of their lives, but this is the cheapest I found.

Rated 4 out of 5 stars
By Jenn on Aug 5, 2020

This saved my dogs life

This medicine saved my dogs life when diagnosed with EPI. It took 6 months to finally find a vet that figured out what was wrong with him and he was so thin and malnourished I wasn't sure if he was going to make it. Within 1 day of adding Epizyme to his food his stools firmed up and he started to gain weight right away. He is now 49 pounds and thriving. I give this a 4 star because of a few reasons. One it can cause ulcers in the mouth and my dog started to get redness around his gums and teeth cracking. The medication states to let it sit for 10 mins but after doing extensive research I found out it is best to thoroughly stir in the powder with water and let sit for 30 mins before feeding making sure all food is coated and that you can not see any of the powder. This helped and my dogs gums are not red anymore but I am still concerned about his cracked teeth. This could not be from the medication but malnutrition from him being sick but not sure. Wish the vet would have told me about this so I could have known to let the medication sit. Second issue is that after about a month and a half the medication seems to loose its effectiveness and I read about this recently that this is a common issue with Epizyme. The first time it happened I thought It was because I was traveling a lot and the heat of the medication being in my car might have damaged the enzymes. So now when I travel with it I put it in a lunch bag with an ice pack and now a month and a half later my dogs stools are getting a little mushy and not as firm as they should be. This medication is so expensive and I buy the bigger bottles because it is more affordable this way but now I have had to throw 2 bottles that were 1/2 full away. It is hard to find information on what temps this medication should be stored at but I did finally find a source that said between 50 to 77 degrees. My house stays about 79-80 degrees and I have been struggling with how to store this in a cooler place. You can't put it in the fridge and I can't afford to keep my AC running 24-7 AT 75 degrees. I have done a lot of research on alternative enzymes and going to give Pan-tenex a try. Hope this information helps anyone with a dog that has EPI and can help them avoid some of the stuff I had to learn the hard way.

Rated 5 out of 5 stars
By Joanne on Mar 5, 2020

pancreatitus enzyme powder

I have a poodle mix that the vet put her on pancreved powder after a pancreatitis episode. I looked online and found epizyme and it had the same ingredients but was more reasonable in price. My girl has been on it for several weeks and is doing great. The only thing that would help would be a 1 tsp scoop that had a long handle. To make scooping it out easier.