Equidone Gel for Horses, slide 1 of 1

Equidone Gel for Horses, 25-mL Multi-Dose Syringe

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Equidone Gel for Horses is prescribed by veterinarians to treat and help prevent fescue toxicosis, a disorder caused by an endophytic fungus which infects tall fescue grass. Equidone Gel is FDA-approved to help prevent fescue toxicosis and can provide less stress for you during foaling and rebreeding.

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For prevention of fescue toxicosis, a warm season condition characterized by reduced feed intake and weight gains or milk production, in periparturient mares.

Possible Side Effects

The most common adverse reactions associated with treatment with Equidone Gel are premature lactation (dripping of milk prior to foaling) and failure of passive transfer.

Drug & Food Interactions

Horses with hypersensitivity to domperidone should not receive Equidone Gel.


Equidone Gel may lead to premature birth, low birth weight foals or foal morbidity if administered > 15 days prior to the expected foaling date. Accurate breeding date(s) and an expected foaling date are needed for the safe use of Equidone Gel. The safety of Equidone Gel has not been evaluated in breeding, pregnant and lactating mares other than in the last 45 days of pregnancy and the first 15 days of lactation. The safety in stallions has not been evaluated. The long term effects on foals born to mares treated with Equidone Gel have not been evaluated. Do not use in horses with suspected or confirmed gastrointestinal blockage. Use of Equidone Gel may cause a false positive on the milk calcium test used to predict foaling.

  1. Prescribing Information

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  • Item Number
  • Generic Name
  • For Use With
  • Common Brand Name(s)
  • Administration Form
  • Product Form
  • Health Condition
    Unhealthy Weight
  • Drug Type
    Adrenergic Agent

Equidone Gel is supplied in disposable, multi-dose, 25 cc syringes, each containing 2.75 g of domperidone suspended in an oral gel. Each cc of gel contains 110 mg of domperidone.

Recommended Dosage

Orally administer 0.5 mg/lb (1.1 mg/kg) once daily starting 10 to 15 days prior to Expected Foaling Date (EFD). Treatment may be continued for up to 5 days after foaling if mares are not producing adequate milk after foaling.

Storage Instructions

Store at controlled room temperature 77°F with excursions between 59°-86°F permitted. Recap after each use.


How is Equidone Gel given?

  1. Determine the appropriate dose for the body weight of the mare based on the dosing table below. One cc will treat 220 lb (100 kg) of body weight.

  2. Turn the dial ring until the edge of the ring nearest the tip of the syringe lines up with the dose to be delivered.

  3. Remove the syringe cap.

  4. Make sure the horse's mouth is free of food or other obstructions.

  5. Insert the nozzle of the syringe through the interdental space of the horse's mouth and deposit the gel on the back of the tongue by depressing the plunger.

  6. Recap the syringe. This is a 25 cc multi-dose syringe. Please note that for subsequent doses, it will be necessary to adjust for previous doses. For example, if the intended dose for a horse is 5 cc, then the dial ring is set at 5 cc for the first dose, at 10 cc for the second dose, at 15 cc for the third dose, at 20 cc for the fourth dose, and at 25 cc for the fifth dose.

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