Fluoxetine (Generic) Oral Solution, 20 mg/5mL, 4-oz bottle

Prescription Item

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Description

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that is prescribed to treat a variety of behavioral problems caused by separation anxiety and obsessive-compulsive disorders. It works by increasing the effectiveness of serotonin in the brain, which aids in the management of anxiety and depression. The FDA has approved this drug for use in dogs to treat canine separation anxiety. It may take several weeks before you and your veterinarian can decide if this medicine is working as desired.

Uses

Fluoxetine is indicated for the treatment of canine aggression and canine seperation anxiety in conjunction with a behavior modification plan.

Possible Side Effects

Adverse effects included (listed in decreasing order of frequency): decreased appetite, depression/lethargy, shaking/shivering/tremors, vomiting, restlessness and anxiety, seizures, aggression, diarrhea, mydriasis, vocalization, weight loss, panting, confusion, incoordination, and hypersalivation.

Drug & Food Interactions

Fluoxetine should not be used in dogs with epilepsy or a history of seizures and should not be given in combination with drugs that lower the seizure threshold (eg, acepromazine, chlorpromazine). Fluoxetine is contraindicated in animals with a known hypersensitivity to it and in those receiving MAOIs.

Precautions

Fluoxetine should be used with caution in animals with diabetes mellitus because it may alter blood glucose levels. Doses may need to be reduced in animals with severe hepatic impairment.

  1. Prescribing Information

See all items by Fluoxetine

  • Item Number
    193427
  • Generic Name
    Fluoxetine
  • Common Brand Name(s)
    Prozac
  • For Use With
    Dogs
  • Administration Form
    Oral
  • Product Form
    Solution
  • Health Condition
    Anxiety
  • Drug Type
    Inhibitor/Blocker
Ingredients
Ingredients

20mg/5mL fluoxetine.

Instructions
Recommended Dosage

1-2 mg/kg once daily.

Storage Instructions

Store in a tight, light-resistant container at room temperature.

FAQ

How is Fluoxetine useful?

The FDA has approved Fluoxetine for use in dogs for treating canine separation anxiety. Veterinarians may prescribe Fluoxetine for treating behavior problems such as aggression, obsessive-compulsive disorder, and anxiety. You and your veterinarian can discuss why this drug is the most appropriate choice.

What should I tell my veterinarian to see if Fluoxetine can be safely given?

Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions.

  • Other drugs can interact with Fluoxetine, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each.

  • Some ingredients found in flea and tick collars can interact with Fluoxetine, so let your veterinarian know if your animal wore one in the past two weeks or if you intend to have your animal to wear one while it receives this medication (not recommended).

  • Tell your veterinarian about any conditions or diseases your animal may have now or has had in the past.

  • If your animal has been treated for the same disease or condition in the past, tell your veterinarian how well the treatment did or didn't work.

  • If your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug.

  • Tell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your animal has developed in the past.

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    Our vet recommended Fluoxetine to help our recently rescued kitty adjust to her new home and companion cat (both of whom are 9+ years old). She had been in four places (original owner died, family member adopted but surrendered to city shelter in less than a month, then was saved by a local rescue) before we adopted her. While we followed the recommended protocol for introducing her to our other cat, she was extremely aggressive at every opportunity. Our house is an open floor plan so areas that can be closed off are limited. Using a baby-gate at the doorway was marginally successful but she managed to slip through it several times and immediately went into attack mode, howling and screeching Our vet recommended Fluoxetine to help our recently rescued kitty adjust to her new home and companion cat (both of whom are 9+ years old). She had been in four places (original owner died, family member adopted but surrendered to city shelter in less than a month, then was saved by a local rescue) before we adopted her. While we followed the recommended protocol for introducing her to our other cat, she was extremely aggressive at every opportunity. Our house is an open floor plan so areas that can be closed off are limited. Using a baby-gate at the doorway was marginally successful but she managed to slip through it several times and immediately went into attack mode, howling and screeching. We had tried a number of other products (Feliway, Rescue Remedy, ComfortEze, etc.) with no success. This is week #4 on Fluoxetine. Yesterday, after seeing our other cat sitting on the stairs, she used her body weight to pry open the baby gate in order to get through, run down the steps, and attack him. Our vet has told us that if the Fluoxetine does not work, she may “need to be an only cat.” We are already attached to her and cannot bear the thought of giving her up. In addition, the concept of making her adapt to yet another new home is very upsetting. We are hoping that continued use of Fluoxetine will have the desired effect. … more

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