Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that is prescribed to treat a variety of behavioral problems caused by separation anxiety and obsessive-compulsive disorders. It works by increasing the effectiveness of serotonin in the brain, which aids in the management of anxiety and depression. The FDA has approved this drug for use in dogs to treat canine separation anxiety. It may take several weeks before you and your veterinarian can decide if this medicine is working as desired.
Fluoxetine is indicated for the treatment of canine aggression and canine seperation anxiety in conjunction with a behavior modification plan.
Possible Side Effects
Adverse effects included (listed in decreasing order of frequency): decreased appetite, depression/lethargy, shaking/shivering/tremors, vomiting, restlessness and anxiety, seizures, aggression, diarrhea, mydriasis, vocalization, weight loss, panting, confusion, incoordination, and hypersalivation.
Drug & Food Interactions
Fluoxetine should not be used in dogs with epilepsy or a history of seizures and should not be given in combination with drugs that lower the seizure threshold (eg, acepromazine, chlorpromazine). Fluoxetine is contraindicated in animals with a known hypersensitivity to it and in those receiving MAOIs.
Fluoxetine should be used with caution in animals with diabetes mellitus because it may alter blood glucose levels. Doses may need to be reduced in animals with severe hepatic impairment.
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