Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

By Frontline Plus
Rated 3.4245 out of 5 stars


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About This Item


  • Promotes fast-acting, long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.
  • Purr-fect for cats and kittens ages eight weeks or older weighing 1.5 pounds or more.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • Waterproof protection means your pal can still enjoy their favorite outdoor activities and regular grooming routine.

See More





Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Cats

#1 Name in Flea and Tick Protection*

FRONTLINE Plus has been trusted by pet parents for over 20 years.** This fast-acting flea and tick protection contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent further infestations, and provide continuous protection for a full month.  

Protect Your Cat Here, There and Everywhere

Fleas and ticks can be found outdoors and indoors, too! That’s why it’s important to keep your cat companion protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

For Cats Old and Young

FRONTLINE Plus for Cats can be used on cats and kittens as young as 8 weeks and weighing 1.5 lbs. lbs. or more.

Options to Fit Your Needs

Available in 3-, 6-, and 8-dose packs.

Formulation Available for Dogs

You can protect your dogs, too, with FRONTLINE Plus for Dogs!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your cat, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your cat with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Dinotefuran, Fipronil and PyriproxyfenActive Ingredients: Fipronil 9.8%, (S)-Methoprene 11.8%.Active Ingredient s: Fipronil: 9.70%Active Ingredients: Fipronil, (S)-methoprene.
LifestageKitten, Adult, SeniorKitten, Adult, SeniorAdultKitten, AdultKitten, Adult, Senior

Questions & Answers

34 Customer Questions

Is there an expiration date on these treatment packs?
Answer by ChewyAug 29, 2018
This product does not have an expiration date. As long as you keep it at room temperature and sealed in its original packaging, it will remain ready for use.

the Frontline Gold has a 3rd ingredient that kills the eggs, (pyriproxyfen) but Frontline plus also kills eggs?? so what makes this specific ingredient (pyriproxyfen)better if both products kill the eggs?
Answer by ChewyDec 02, 2020
While Frontline Plus and Frontline Gold treat adult fleas in the exact same way, the addition of pyriproxyfen allows Frontline Gold to kill flea eggs and larvae more effectively than Frontline Plus. Frontline Plus can begin killing these pests 4 hours after application, and Frontline Gold may begin killing them as quickly as 30 minutes after application.

Will this kill ticks that are already on my cat?
Answer by ChewyApr 18, 2019
Once applied, FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Kills all life stages of ticks (larva, nymph and adult).

How often should I give my kitten to use this product?
Answer by ChewyOct 14, 2019
One treatment will last 30 days. This treatment should only be used on cats and kittens 8 weeks or older and over 1.5 pounds.

ReviewsWrite a Review

Rated 3.4245 out of 5 stars
1927 Ratings
Would recommend to a friend

1925 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Em on Aug 17, 2023

Love Chewy and keeping my cats safe & healthy

This product frontline we use for all five of our cats. Our cats are indoors but we live in the country so fleas can get inside our home just by jumping on us and coming in doors. Frontline is a non prescription preventative for our cats. It costs less that prescription treatments yet prevents fleas from getting on our cats or trying to bite them. Our cats are kept safe this way and we love chewy for offering this option for our indoor cats. We had once had an infestation of fleas when we first moved to the country and since treating them with this we have had no further problems.

Rated 1 out of 5 stars
By Waffle on Sep 10, 2023

Fleas everywhere!

Been paying for this expensive product for years thinking that it was working. Never missed a dose. I ignored a black dot I found on my cat thinking that there is no way that it is a flea due to the Frontline. THEY WERE ALL OVER BOTH OF MY CATS. Very frustrating 😕 Now that im reading the reviews on Frontline, it seems like Im not the only one experiencing this. Switching to Advantage immediately.

Rated 3 out of 5 stars
By Will on Sep 23, 2023

Not quite right

Better than nothing was what I had to saddle for on my last order I tried to order Frontline gold, but the app refused it took it away like it didn’t exist and I couldn’t pull it up again. I could only find this stuff I think your app needs to be updated or something

Rated 1 out of 5 stars
By Steve on Sep 1, 2023

Is it just my cats or has others gotten immune to this

I've spent a lot of money on this product and it seems to not be working anymore My cats are covered in fleas, are constantly scratching, which makes me feel guilty and now have had to order a large amount of flea spray to spray the entire house, bedding and furniture Has anyone else had this problem

Rated 1 out of 5 stars
By Candyce on Sep 16, 2023


Actually, worse than that. 2 of 4 were sick for 2 days but none of the 4 had reduced fleas after 2 treatments. Didn't bother with the 3rd as it wasn't worth them feeling bad for nothing. Don't waste your money on this product!

Rated 2 out of 5 stars
By Tyler on Sep 4, 2023

Contains Banned Insecticide

Fipronil is an insecticide classed by the WHO as moderately hazardous, and is BANNED as a veterinarian drug for animals in the EU. Be careful when buying and using flea meds in the US; it's poorly regulated. PS it didn't even kill my cat's fleas.

Rated 5 out of 5 stars
By Frankie on Sep 17, 2023

My fleas are gone!

I was a kitten rescued from the streets. I was covered in fleas but frontline for took care of them. It takes three months but the peace of mind knowing that you’ve eradicated them is worth it.

Rated 1 out of 5 stars
By cat on Aug 28, 2023

Terrible product not good for your cats

It's not worth the money to buy I wouldn't even give it a star my cats barely had any fleas bought it for them it says Works in 24 hours didn't even work at all now I have to go find something else and my cats are miserable

Rated 1 out of 5 stars
By Caitlin on Aug 24, 2023

Didn't work

My babies got no relief from this product. Which is a shame, was trying a more cost effective approach but it's clear I'll have to spend more than I have to try and get them the relief they need. Really disappointed.

Rated 2 out of 5 stars
By alycat97 on Jul 19, 2023
Top 1000 Contibutor

Did not work for us…

Purchased these roughly four years ago before finding a brand that my vet recommend and Chewy pharmacy can ship to me quickly and on auto ship. However, I did try these and they didn’t work. Unsure if it’s just us, but seems from previous reviews it’s an issue with multiple pets and probably something off with this brand…