FRONTLINE PLUS Flea & Tick Spot Treatment for Extra Large Dogs, 89-132 lbs, 3 Doses (3-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Extra Large Dogs, 89-132 lbs

By Frontline Plus
Rated 4.1634 out of 5 stars
Pet Weight

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$35.41Chewy Price
$44.99Chewy Price
$33.64Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

20 Customer Questions

How long should I wait to apply Frontline Plus before or after a bath??
Answer by ChewySep 24, 2018
If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application. FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours.

How soon after applying this product should we expect to find no live fleas on our dogs? If we are still finding live fleas, how soon is it safe and advisable to apply a second treatment?
Answer by ChewyJul 11, 2017
The Frontline Plus Flea & Tick Treatment for Dogs will begin working within 12 hours against adult fleas and 48 hours against lice upon application. It's advised to use one treatment per month and not to use it multiple times within 30 days.

does this also repel mosquitoes
Answer by ChewyJun 17, 2017
This product does not repel mosquitoes.

Where is this Frontline made?
Answer by ChewySep 11, 2018
We receive our products right from the manufacturer. Frontline plus is made in France.

ReviewsWrite a Review

Rated 4.1634 out of 5 stars
508 Reviews
Would recommend to a friend

508 Customer Reviews

Filter by reviews that mention

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By sandy on Mar 6, 2023

cheaper then the vet"s

our local vet wants 125 for this same product, our dog is allergic to the pill's he wants him to take. I think that's why he is charging more for this, because we won't continue to give him the pill form he recommended. I guess he gets a kick back on it.

Rated 1 out of 5 stars
By Cody on Feb 19, 2023

Dog still has fleas

Does not repel fleas, my dog still has fleas and has itched herself bald near her tail, belly, and on one leg. Switching back to K9 advantix II which had worked for us before.

Rated 5 out of 5 stars
By 5DogMom on Nov 20, 2022


I have used Frontline for many years and never had a tick or flea issue. I used Bravecto, but it has gotten very expensive, especially with 5 fur babies. I purchased Frontline Plus and so far so good, but it will take awhile before I see the effects for certain. I was disappointed to find after using one out of each pack to find it less expensive at another store. The Chewy rep offered to accept a return but I had already opened it. Fast shipping!

Rated 2 out of 5 stars
By Goober on Jan 8, 2023

Front line

Does it job But makes dog stink After professional groom also starts moving around the stink starts coming off every where naturally cause it in his blood stream

Rated 5 out of 5 stars
By Boxerlover on Jan 21, 2023

Great product

Been buying from chewy for years. Great service with fast delivery. Product has been correct every order, much cheaper than the retail stores.

Rated 5 out of 5 stars
By Peanut on Mar 8, 2023

Frontline Plus

I've used Frontline Plus for years to keep my dogs flea and tick free. It works!

Rated 1 out of 5 stars
By Annie on Nov 10, 2022

Doesn’t kill ticks

I put this on my 130 lb boy, as we live in a wooded area, and since I put it on, I’ve taken about 10 ticks out of him. We switched from another brand, and I’m really upset that we did. Used to work on our old dogs, don’t know what happened. Don’t waste your money.

Rated 1 out of 5 stars
By Kylena on Oct 22, 2022

Doesnt kill fleas

Ive always used Frontline Plus or Advantage II(cats) or Advantix II, and for whatever reason this year Zero of those have worked at all. I treat the animals like clockwork, and have even gone as far as treating every 3 weeks instead of once a month and I STILL HAVE FLEAS!

Rated 2 out of 5 stars
By April on Aug 29, 2022

Frontline Plus-

the frontline doesnt work, we have used this in the past and have had to switch to a stronger protection, I ordered this product thinking it was a chewable and that you didnt need a prescription when it arrived it was a topical and just wasnt strong enough. I cancelled my auto ship for that product and placed it with Bravedo which is what our vet highly recommed and works well, so hopefully we will see when out next shipment arrives if we continue.

Rated 2 out of 5 stars
By 4DogMom on Aug 18, 2022

Doesn’t seem effective

This came up as the “best topical flea medicine” on my google search and also had a good rating on Chewy so I figured this is the one. Unfortunately 3 out of my 4 dogs don’t seem to be getting much (if any) relief from it. The one out of four dogs who it does seem to be helping us the one who didn’t seem to need it to begin with because he wasn’t biting and scratching to begin with. I’ll keep trying again next month when it’s time for their application but very doubtful that I’ll be continuing the subscription after that.