Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline Plus
Rated 3.9334 out of 5 stars

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$35.86Chewy Price
$44.99Chewy Price
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$9.13 (20%)
$34.07Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.8%, (S)-Methoprene 8.8%.
LifestagePuppy, Adult, SeniorAdultAdultPuppy, Adult, SeniorAdult
Breed SizeExtra Small Breeds, Small BreedsExtra Small Breeds, Small BreedsSmall Breeds, Medium BreedsSmall Breeds, Medium BreedsMedium Breeds, Large Breeds

Questions & Answers

35 Customer Questions

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

Does it continue to work after bathing dog or do you need to reapply?
Answer by ChewyApr 03, 2018
This treatment provides waterproof effectiveness so that it won't wash off from swimming or baths.

My dog has a thick coat as she's part Pomeranian & I never know if it's getting on her skin instead of her fur?
Answer by ChewySep 27, 2019
To apply, part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin. Then, squeeze applicator to apply entire contents in a single spot on the skin monthly.

ReviewsWrite a Review

Rated 3.9334 out of 5 stars
1471 Ratings
Would recommend to a friend

1439 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Charles on Nov 10, 2023

Something went wrong

I have used this and the generic version over the past three years. We purchased this last month and within ten days it looked like fleas were growing on my dog. They were jumping everywhere and my dog was constantly itching worse than before we put the flea killer on her. I guess this was a bad batch. Going to go purchase the pills at my vet and never use this again.

Rated 1 out of 5 stars
By Kim on Nov 17, 2023

Does Not Work

Bought this to treat my dog for fleas. Applied as directed and a week later she is still covered with fleas. Waited til I could do the 2nd application, again, I followed the directions exactly, she still has fleas. I won't be buying this again. I think I should get a refund because it did absolutely nothing.

Rated 5 out of 5 stars
By Sandie on Nov 14, 2023

Awesome!! Frontline Plus

I ordered flea medicine for my dogs even though it was lost for a second chewy was ready to help cover the issue and fix it immediately and I absolutely appreciate that. I will be ordering from Chewy again soon.

Rated 5 out of 5 stars
By ANNETTE on Nov 15, 2023

Dogs won't take medicine by mouth

Our dogs are very picky about what goes into their mouths. Chewable flea and tick Chewables won't work. The Front Line liquid on the back of the neck has always been our choice and it has never let us down.

Rated 5 out of 5 stars
By Miranda on Nov 15, 2023

Highly recommended Frontline Flea Care

I have been using this flea care for years on my pet. Never once have I had any issues or emergencies. As long as you use it on time each month, it works well each time.

Rated 1 out of 5 stars
By Meghan on Oct 30, 2023

This does not work I have not used a preventative in years decided that I would this year and by the end of the week my dog had a fully engorged tick by his ear! DO NOT BUY THIS IT DOESNT WORK!

Rated 1 out of 5 stars
By Jo on Oct 1, 2023

Terrible product

I bought for my dogs and I believe I got a bad batch because I've used this for years with no problems and this time it did not kill any of the fleas it didn't work at all.....I called the company and they wouldn't even stand behind their own product. Will never buy again.

Rated 5 out of 5 stars
By Anne on Aug 31, 2023

Fleas do not bite

My dog has flea saliva allergy . Other flea products which are oral require a bite to kill . This one is spread through glands to surface of skin and repels and kills without a bite . Eggs and larvae are dead too . Big plus ! Works to kill ticks as well . Best price for a great product . We switched 6 months ago off Nexguard . Glad we did .

Rated 1 out of 5 stars
By Angela on Oct 4, 2023

Absolutely does not work

So disappointed in this. Moved from Las Vegas to North Carolina. Planned ahead and purchased this for my Shih tzu. Absolutely does not work. My poor Dog is Absolutely infested with fleas and eggs. Don't waste your money.

Rated 1 out of 5 stars
By Amy on Oct 21, 2023

Not Effective

Frontline seems to work less every time I use it, and I am ready to move on to a different brand. I suspect the manufacturer has been cutting corners to make more money.