Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs

By Frontline
Rated 4.0656 out of 5 stars
Slide 1 of 12
Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 3 Doses (3-mos. supply) slide 1 of 12
Slide 1 of 12
Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 3 Doses (3-mos. supply) slide 1 of 12

Special Offer

Price as marked
$33.14Chewy Price
$44.99Chewy Price
$31.48Autoship Price
Autoship (Save an extra 5%)
Choose Autoship at checkout for regular deliveries.

Why Autoship?

  • FREE access to chat with licensed vets 7 days a week.
  • Save 5% on all future Autoship orders.
  • No fees, no commitments - cancel Autoship anytime.

In Stock
FREE 1-3 day shipping over $49

Frequently Bought Together

This Item - Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs, 3 Doses (3-mos. supply)
Rated 4.0656 out of 5 stars
$33.14Chewy Price

Special Offer

Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box), 6 Chews (6-mos. supply)
Rated 4.9166 out of 5 stars
$45.99Chewy Price

Save Extra 20% on First Autoship

Interceptor Plus Chew for Dogs, 8.1-25 lbs, (Green Box), 6 Chews (6-mos. supply)
Rated 4.6894 out of 5 stars
$43.59Chewy Price
Total Price: $0.00

About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline From Our Team of Experts
Learn More About Frontline From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Compare Similar Items

Customer Rating
Rated 4.0656 out of 5 stars
Rated 3.7875 out of 5 stars
Rated 4.177 out of 5 stars
Rated 4.1009 out of 5 stars
Rated 4.3204 out of 5 stars
$33.14Chewy Price
$42.99Chewy Price
$33.14Chewy Price
$33.14Chewy Price
$33.14Chewy Price
$31.48Chewy Price
$40.84Chewy Price
$31.48Chewy Price
$31.48Chewy Price
$31.48Chewy Price
Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.80%, (S)-methoprene 8.80%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
LifestagePuppy, Adult, SeniorAdult, Puppy, SeniorAdult, Senior, PuppyAdult, Puppy, SeniorAdult
Breed SizeExtra Small & Toy Breeds, Small BreedsSmall BreedsSmall Breeds, Medium BreedsMedium Breeds, Large BreedsLarge Breeds

Questions & Answers

35 Customer Questions

Is Frontline Plus and Frontline Gold the same?
Answer by ChewyMay 15, 2018
FRONTLINE Gold is the latest innovation in flea and tick protection from the maker of FRONTLINE Plus. In addition to having fipronil and (S)-methoprene, they now added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop into adult fleas. Regular use of FRONTLINE Gold helps prevent new flea infestations.

Does frontline plus expire
Answer by ChewySep 19, 2019
This product doesn't expire. It will be usable until each individual dosage is opened.

Is this safe for dogs under 5lbs?
Answer by ChewyJul 16, 2017
Frontline Plus for Small Dogs & Puppies is for 5-22 pounds. For smaller dogs, consult with a veterinarian to determine the best method of protection.

I regularly use Frontline, but not frontline plus. I can not get the fleas under control during peak months and still see a few during the winter. I use this product year long. I also use flea spray around the 4th week.Will frontline plus help?
Answer by ChewyJan 30, 2018
Frontline Plus protects against all stages adult fleas, ticks, chewing lice, mites, and flea eggs and larvae,

ReviewsWrite a Review

Rated 4.0656 out of 5 stars
1219 Reviews
Would recommend to a friend

1219 Customer Reviews

Rated 5 out of 5 stars
By Annette on Jun 22, 2022

Excellent protection against fleas and ticks!

I have used this product for years for flea and tick protection for both dogs and cats. It is easy to use--just once per month topical application is quick--no fuss, no muss. I recommended it to a neighbor, and her veterinarian approved it, and even carries it for sale in his practice. Of course it's more affordable through and arrives in lightening-fast time!

Rated 4 out of 5 stars
By Kathleen7 on Jun 21, 2022

Frontline Plus is Okay

That's a generous 4 stars, but from what I hear there really aren't any great options. I am grateful the fleas don't seem as bad as they did before. I wish someone would come out with a product the actually works as intended.

Rated 5 out of 5 stars
By Samantha on Jun 28, 2022

Messy, but works great!

We've used frontline for years and it has never failed us. The few times we've tried other products, we ended up with ticks, fleas or both. It's a messy application, but it works.

Rated 5 out of 5 stars
By Dachshundmom on Jun 26, 2022

Frontline is a good product

I have used Frontline for years, to prevent fleas and ticks from infesting my dog and house. The convenience os ordering from Chewy and having it delivered here is wonderful.

Rated 5 out of 5 stars
By Remoteness on Jun 24, 2022

Needed and Convenient

Since we now live miles and miles away from . . . . everything, it is such a break to be able to get the pet's needs sent to our door quickly, affordably, and without hassle.

Rated 5 out of 5 stars
By Dogmom on Jun 9, 2022

Amazing product

I chose Frontline because in all the years I have had dogs I have never had a flea problem. Tried a cheaper product that someone gave me and it made my little guy throw up. That has never happed with Frontline

Rated 2 out of 5 stars
By Scooby on Jun 18, 2022

Heartgard products

Products too expensive for so little quantity. All items except medications should be readily available without a vet approval especially Heartgard should be without a vet's approval

Rated 5 out of 5 stars
By Trish on Apr 6, 2022

Can Always Count On Chewy

Having pets is the most gratifying experience ever, but often we may forget their needs. Sometimes we don’t actually forget, rather we try to balance the economical impact. Having three fiercely loyal little pups who need their food, treats, vets, etc, life gets a little overwhelming. As the days got warmer in NJ, I realized my tittle ones didn’t have flea protection. I instantly got on Chewy’s site, placed the order for the medicine and relaxed. With Chewy I am confident of best price, safe packaging, and quick delivery. What a wonderful family owned business!

Rated 4 out of 5 stars
By Cristina on Apr 2, 2022

Works OK, dog tolerates it OK but doesn't love it

I used this for about 6 months, after trying a new oral medication that made my dog sick. This topical works well. I would have kept using it but had to stop because my dog hates topicals, she is terrified as soon as I open the box and she senses it's Frontline time. The last time she completely freaked out, so it must bother her, maybe it burns or something, I don't know. It does dry quickly and she was behaving normally that day and the day after, so it didn't affect anything except perhaps her skin and her mood, lol. If your dog tolerates it, I think it's fine to use and less toxic than other topicals.

Rated 2 out of 5 stars
By Sweetgirl on May 31, 2022

Nothing is working this year!

We have treated our yard and put Frontline Plus on our dogs but we can not get rid of the fleas this year. They are even in our garage. Set six foggers off in garage then four more and still have fleas. Crazy.