FRONTLINE PLUS For Cats and Kittens Flea and Tick Treatment -

Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs

By Frontline Plus
Rated 3.5531 out of 5 stars

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$146.46Chewy Price
$139.14Autoship Price
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About This Item


  • Promotes fast-acting, long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.
  • Purr-fect for cats and kittens ages eight weeks or older weighing 1.5 pounds or more.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • Waterproof protection means your pal can still enjoy their favorite outdoor activities and regular grooming routine.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Cats

#1 Name in Flea and Tick Protection*

FRONTLINE Plus has been trusted by pet parents for over 20 years.** This fast-acting flea and tick protection contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent further infestations, and provide continuous protection for a full month.  

Protect Your Cat Here, There and Everywhere

Fleas and ticks can be found outdoors and indoors, too! That’s why it’s important to keep your cat companion protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

For Cats Old and Young

FRONTLINE Plus for Cats can be used on cats and kittens as young as 8 weeks and weighing 1.5 lbs. lbs. or more.

Options to Fit Your Needs

Available in 3-, 6-, and 8-dose packs.

Formulation Available for Dogs

You can protect your dogs, too, with FRONTLINE Plus for Dogs!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your cat, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your cat with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 11.8%.Dinotefuran, Fipronil and PyriproxyfenActive Ingredients : Fipronil , (S)-methoprene , Pyriproxyfen.Active Ingredients: Fipronil, (S)-methoprene.Active Ingredients: Imidacloprid 9.1%, Pyriproxyfen 0.46%.
LifestageKitten, Adult, SeniorAdult, Kitten, SeniorAdult, Kitten, SeniorAdult, Kitten, SeniorAdult

Questions & Answers

32 Customer Questions

Is there an expiration date on these treatment packs?
Answer by ChewyAug 29, 2018
This product does not have an expiration date. As long as you keep it at room temperature and sealed in its original packaging, it will remain ready for use.

Will this kill ticks that are already on my cat?
Answer by ChewyApr 18, 2019
Once applied, FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Kills all life stages of ticks (larva, nymph and adult).

How often should I give my kitten to use this product?
Answer by ChewyOct 14, 2019
One treatment will last 30 days. This treatment should only be used on cats and kittens 8 weeks or older and over 1.5 pounds.

the Frontline Gold has a 3rd ingredient that kills the eggs, (pyriproxyfen) but Frontline plus also kills eggs?? so what makes this specific ingredient (pyriproxyfen)better if both products kill the eggs?
Answer by ChewyDec 02, 2020
While Frontline Plus and Frontline Gold treat adult fleas in the exact same way, the addition of pyriproxyfen allows Frontline Gold to kill flea eggs and larvae more effectively than Frontline Plus. Frontline Plus can begin killing these pests 4 hours after application, and Frontline Gold may begin killing them as quickly as 30 minutes after application.

ReviewsWrite a Review

Rated 3.5531 out of 5 stars
1741 Reviews
Would recommend to a friend

1741 Customer Reviews

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Rated 2 out of 5 stars
By Liesl on Jan 23, 2023

Fleas are evolving, but the formula hasn’t!

Bought a 6 month supply at a wholesale retailer and wanted to come here with a warning from my vet. PNW flea populations are growing immunity to this formula because it has been around for so long. Been treating my cats for 3 months and while I do believe it has kept it under relative control and I had yet to see any fleas myself (hence 2 stars instead of 1), both my cats are still covered in miliary dermatitis and the vets just found fleas on both today. I’m not happy at all. Going to switch to Revolution at my vet’s recommendation.

Rated 5 out of 5 stars
By Sacha on Jan 20, 2023

No flea problems ever.

Don't like the greasy spot on kitty's back neck, but the protection works. Itching stops within a short time and I don't get flea bites from petting my cat. Never see any ticks. She is an indoor cat but mingles with the dogs. And on a rare occasion, will run out the door but come back within an hour. So, I never need to worry about her bringing home unwanted bugs while using Frontline. It is a little pricey, but I feel like it is necessary.

Rated 1 out of 5 stars
By DaisyAnn on Jan 30, 2023

didn't work

This didn't work on my cat. He has really thick fur, but I think we got a good application on his skin. Unfortunately, he still has a lot of fleas. We'll wait a month and try again, but this is disappointing.

Rated 4 out of 5 stars
By Rhonda on Jan 2, 2023

Damaged box

This was in the box where all the heavy stuff was thrown on it. I would recommend for future shipments to put in a small cardboard box so it does not get damaged during shipment. Box was opened but the individual packs were fine.

Rated 5 out of 5 stars
By Ashley on Dec 26, 2022

I have 4 cats, one with a flea allergy

I adopted two outside cats covered in fleas, used this, and within hours most of the fleas were dead. I have 4 cats, one of which has a flea allergy. We’ve been using this medicine for over 5 months now (before we used Revolution) and it seems to be doing the job- no allergy flare up or flea dirt. Would recommend.

Rated 1 out of 5 stars
By Annie on Dec 21, 2022

Have Been Using 3 Months - Doesn’t work

I have 2 indoor cats that I’ve had for 6 years and for some reason this year they both got fleas which they’ve never had. I have been using this on both cats for 3 months and even after this, cleaning, spraying the house, flea baths, etc they have live fleas. Giving cats a bath is not enjoyable I need something that actually works.

Rated 1 out of 5 stars
By Steve on Nov 20, 2022

product tampering

ordered 8 count frontline plus. Received 2 of the 4 count packets which was ok. What was not was that both pakets had been opened. Whoever did that didn't even bother to cloth the packets correctly. They left the little side flaps hanging out. Will not use products that have been tampered with. Although the doses themselves appear in tact, I have no idea if they were swapped out for doses that had expired. Will not order from Chewy again. The button below asks if I would recommend this product to a friend. Yes I would but not through Chewy so I am selecting the no button.

Rated 3 out of 5 stars
By Rebecca on Nov 12, 2022

Not for My Cats

I have two cats and I applied this product to each of them on same day. One cat had no issues. My other cat developed a severe allergic reaction. She licked herself so much she licked off a good bit of her hair and had several sores on her body from the licking, not to mention all the scratching she did. After about a month, the product worked itself out of her system and she is okay now. Her hair has returned. I purchased this product mainly bc it offered tick protection, and as far as I know, the product worked as described, but due to the allergic reaction, I can't use it on one of my cats. I will use the remaining doses on the cat that isn't allergic. Of note, I have used Revolution and Cheristin on this cat with no issues.

Rated 5 out of 5 stars
By Gracie on Jan 24, 2023

Chewy is Right on

I have used Frontline previously with my dog so i was not disappointed when Frontline for cats was used for my new cat. The product is easy to apply to the cat and is effective.

Rated 1 out of 5 stars
By Beth on Nov 29, 2022

Vet would NOT recommend

Once telling my vet that I used Frontline Plus to treat fleas on my cats, their response was to stop wasting money. Over the past few years there has been a heightened resistance of fleas to Frontline Plus which makes it hardly, if at all, effective. This would explain why, after 3 months we are still fighting live fleas on our cats between spraying the entire house, monthly flea treatments on all animals, incessant vacuuming & cleaning, and multiple flea baths. I treated my dog with a different monthly, oral flea treatment and there have been Zero flea signs on her. Needless to say, the cats have now been changed to the same brand of monthly flea treatment and we will not be purchasing Frontline Plus again.