FRONTLINE PLUS Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 12 Doses (12-mos. supply) -

Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline Plus
Rated 3.9239 out of 5 stars
Pet Weight

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$131.30Chewy Price
$124.74Autoship Price
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  • Save 5% on all future Autoship orders
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About This Item


  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

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Play Video: Learn More About Frontline Plus From Our Team of Experts
Learn More About Frontline Plus From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

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* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

Questions & Answers

32 Customer Questions

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.
Answer by ChewyJun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

ReviewsWrite a Review

Rated 3.9239 out of 5 stars
1419 Reviews
Would recommend to a friend

1419 Customer Reviews

Filter by reviews that mention

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 4 out of 5 stars
By CG08 on Feb 26, 2023


The product is fine. Oversight on my part. I thought it was a pill versus the liquid solution. I prefer chewables. I think it is more effective versus the liquid applied to the neckline and back. There is nothing wrong with the product. Just a preference.

Rated 3 out of 5 stars
By Cobber on Dec 14, 2022

Not so much

I contacted Frontline to see if I could decrease amount for a dog at 45 pounds; no. I would prefer a more accurate dose per pound of dog weight to reduce toxins. Green blue dye discolors my cobberdog cream fur. Dog had engorged tick on face after use and multiple ticks on body. I have had 2 ticks attached to my body which required medical attention and bills. Ticks probably crawled off dog. However, it seems to be less toxic and without permethrin which can kill cats. I have used product on dog for 4 months, but now spray with wondercide as well on my furniture, and prior to rare walk in woods.

Rated 1 out of 5 stars
By Katrina on Nov 10, 2022

My dog got lyme's disease

Frontline used to work well 20 years ago. I recently adopted a puppy, he had a lyme's test, and was negative. I applied frontline to him every 4 weeks, at least 48 hours after his bath. At his 1 year vet check, he had lyme's disease. I still had a box of frontline with 5 doses left (he was done growing at this point) so I figured I'd apply it until I ran out, then switch over to an oral preventive. I still have 3 doses left, and over the past summer/fall months I have found multiple ticks on him, either crawling or attached and feeding (and unfortunately they are large by the time I find them). The preventative seems to be doing nothing to prevent ticks. I wish they didnt advertise it as a tick prevention, then perhaps my dog wouldn't have lyme's disease at such a young age. I wouldn't recommend Frontline anymore, I think the ticks have grown immune to the ingredients. Even with the small seizure risk, oral preventives seem like the best route nowadays if you want protection from ticks.

Rated 1 out of 5 stars
By Didntwork on Jan 19, 2023

Did not work

We have 2 dogs both using Frontline. It discolored 1 dog’s fur in a few spots (per the vet) and the worst, they had live fleas on them after months of being shampooed regularly and Frontline applied as directed.

Rated 1 out of 5 stars
By nightstork on Mar 9, 2023

severe reaction

our dog had a bad reaction ,welts, vomiting. had to take her to the vet for treatment, it was really scary

Rated 5 out of 5 stars
By Shmoo on Feb 24, 2023

Convenient and Priced Right

As a first time customer, I am pleased to say all went well. Product came as ordered and on time. Loved my first time discount!

Rated 5 out of 5 stars
By Nichole on Mar 14, 2023

Flea medication

My go to flea and tick treatment. I have used this for years without any issues or side effects.

Rated 1 out of 5 stars
By roxy on Nov 22, 2022

Didn't work

My dog has been on Frontline monthly preventative for years. Recently I found live fleas on her just 4 days after her Frontline dose. Continued to find live fleas on her for 3-4 days until her vet prescribed Capstar to kill the adult fleas. That worked quickly. She was flea free for about 4 days and now finding fleas on her again so clearly the Frontline is not working. All carpet has been vacuumed daily and treated with flea spray, all bedding washed daily etc.

Rated 4 out of 5 stars
By Emjay on Nov 4, 2022

Good Product, But Price Increased $5 after 5 days

This is a good product that has been effective for us for many, many years. However, I am dropping one star because the fluctuation in prices is insane. About 5 days ago, I checked and wrote down the price of a 3-month dose supply on my notes. It was $33.23 with autoship. Now, 5 days later on November 4, 2022, it is $38.94! That is ridiculous. I have seen similar price changes in other products I use for my pets, and have seen $10-$20 (additional) change in prices in a span of a few days. Terrible.

Rated 2 out of 5 stars
By Sherry on Nov 1, 2022

Not Working

I use to buy this product for my dogs all the time and we never had an issue with fleas. But a pet store told me to try the flea collar they had that they were great and would last for months. Well for the first time ever my dogs got infested with fleas, So I did everything I could to kill the existing fleas with flea shampoo and Dawn. Then i went back to Frontline. Don't know if they changed the ingredients or if we have super fleas but there are atill active fleas. I do the second dose in 2 weeks. Hopefully it will kick in and start working. I will try the second dose before I say buy it or not.