Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs

By Frontline
Rated 4.1009 out of 5 stars
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply), bundle of 2 (12-mos. supply) slide 1 of 13
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Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply), bundle of 2 (12-mos. supply) slide 1 of 13

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$122.38Chewy Price
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This Item - Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply), bundle of 2 (12-mos. supply)
Rated 4.1009 out of 5 stars
$122.38Chewy Price

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About This Item

  • Promotes a fast-acting and long-lasting protection from fleas and ticks.
  • Formulated with two active ingredients to help disrupt the flea life cycle.
  • Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks.
  • Simply apply once a month.
  • Designed for a waterproof protection after 24 hours.
Play Video: Learn More About Frontline From Our Team of Experts
Learn More About Frontline From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

About FRONTLINE Plus for Dogs

#1 Name in Flea and Tick Protection*

FRONTLINE Plus is proven flea and tick protection that has been trusted by pet parents for over 20 years.** Just one dose of FRONTLINE Plus provides fast-acting protection that lasts for a full 30 days.

Break the Flea Life Cycle

FRONTLINE Plus contains fipronil, which kills adult fleas, as well as (S)-methoprene, which kills flea eggs and larvae. Together, these active ingredients break the flea life cycle, prevent future infestations, and provide continuous protection for a full month.

Protect Your Dog Here, There and Everywhere

Fleas and ticks can be found at the park, the lake and in your own backyard. That’s why it’s important to keep your dog protected month after month.

The #1 Name

FRONTLINE is the #1 name in flea and tick protection.*

Long-Lasting Protection

One dose of FRONTLINE Plus for Cats lasts a full 30 days.

Fast-Acting Formula

Once applied to your cat, this powerful formula kills fleas, ticks and chewing lice on contact.


FRONTLINE Plus is waterproof 24 hours after application.

Trusted Protection

FRONTLINE Plus has been trusted by pet parents for over 20 years.**

Effective for Puppies

FRONTLINE Plus for Dogs can be used on puppies as young as 8 weeks and weighing at least 5 lbs.

For Dogs Big and Small

Choose from four formulas—Small 5-22 lbs., Medium 23-44 lbs., Large 45-88 lbs., and Extra-Large 89-132 lbs.

Formulation Available for Cats

Protect your cats with FRONTLINE Plus for Cats!

Pests Can Be a Year-Round Threat

Flea infestations usually begin 6-8 weeks before you ever notice a flea on your dog, and once your home is infested, it can take up to 90 days to eliminate all stages of the flea life cycle. Protecting your dog with FRONTLINE Plus monthly, year-round can help prevent reinfestations.

Protect Year-Round with Autoship

Sign up for Autoship today and save on FRONTLINE Plus. You’ll get a discount on every order of FRONTLINE Plus, and you can rest easy knowing that you’ll never run out of proven flea and tick protection.

The Mission

Boehringer Ingelheim, the maker of FRONTLINE Plus, is committed to enhancing the well-being of pets and supporting the animal health community through science and innovation. No animal should have to suffer a preventable disease, which is why Boehringer Ingelheim develops products like FRONTLINE Plus.


FRONTLINE Plus is the #1 name in flea and tick protection.* It’s formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. FRONTLINE Plus is waterproof 24 hours after application, lasts for a full 30 days and has formulations available for dogs and cats. With FRONTLINE Plus, you can take your pet everywhere.

Shop Frontline

* Data on file at Boehringer Ingelheim

** Data on file at Boehringer Ingelheim

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Top IngredientsActive Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.Active Ingredients: Fipronil 9.80%, (S)-methoprene 8.80%.
LifestageAdult, Puppy, SeniorAdultAdult, Senior, PuppyPuppy, Adult, SeniorAdult, Puppy, Senior
Breed SizeMedium Breeds, Large BreedsLarge BreedsSmall Breeds, Medium BreedsExtra Small & Toy Breeds, Small BreedsMedium Breeds, Large Breeds

Questions & Answers

31 Customer Questions

What would happen if I give my dog who is slightly under the weight limit the same amount as my dog who is slightly over the weight limit? I don't want anything to happen to her but I'd much rather just split the 6 month pack between them as I've never used this brand before.
Answer by ChewyDec 05, 2017
You may be slightly under or over as long as your dog is within 5 pounds of the limit. If not, we recommend going with the next size.

How does it protect your dog when you only apply by the back of the neck
Answer by ChewyNov 21, 2017
Once FRONTLINE Plus is applied, it stores itself in the oil glands in your pet's skin. It then self-distributes continuously for one month to your pet's hair and skin through the hair follicles, killing fleas and ticks.

Can this be taken by a dog that also takes a heart worm pill with flea prevention in it?
Answer by ChewyJun 09, 2021
We encourage speaking with your Veterinarian before combining flea and tick preventatives, for the safest opinion.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.
Answer by ChewyJun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

ReviewsWrite a Review

Rated 4.1009 out of 5 stars
1269 Reviews
Would recommend to a friend

1269 Customer Reviews

Rated 2 out of 5 stars
By Nicole on Jul 1, 2022

Doesn't work after several months

My dog hasn't ever had fleas before. We switched from K-9 Advantix to Frontline, and I understand it takes a few months to fully adjust but I have been applying Frontline as directed for months now and I don't see that it is working. For the first time, my dog got fleas and it doesn't seem like this topical medication helps at all. It may work for others, but it definitely didn't work for us which is a disappointment after spending a lot due to other's great reviews.

Rated 1 out of 5 stars
By Nope on Jun 13, 2022

Don’t buy. Not worth your time and money.

You’re better off going outside, lighting your money on fire and watching it burn. That will be more pleasurable than buying and waiting for a FLEA TREATMENT that absolutely does not kill or repel fleas. If you decide to purchase you will be left with time wasted calling these companies, all while the fleas do the boogie on your pets. And the money is spent to the companies and out of your pocket. Duped. Purchase something better, probably from the veterinarian, I’m going to have to. Good luck.

Rated 5 out of 5 stars
By Kaya on Jun 22, 2022

Love this product!

I feel comfortable using frontline plus for dogs on our family golden retriever. There has never been any issues whatsoever with ticks, fleas, etc. This stuff seems to have always worked. Our family definitely has seen ticks in our backyard but this stuff has always protected out dog against the insect. Works for us! I also use the frontline plus for cats on our kitty with no issue.

Rated 3 out of 5 stars
By Kathy on Apr 23, 2022

Seems to work, but dog hates it.

I've used Frontlline for many years on different dogs, and it works, as I've never noticed any fleas, ticks or other nasty critters on my dogs after using it regularly. That being said, all my dogs hated having it applied. And I mean HATE. They would hide when I brought it out of the closet, and attempt to rub it off afterwards by rubbing along the side of the couch, the carpet, or rolling in the grass outside in an effort to get it off. I don't know why. With my current dog, because of my experience with previous dogs disliking the product, I started using an oral product instead, but it was so expensive, and required a prescription, so I went back to Frontline again. It works, but like my other dogs, she hates it being applied to her skin. Maybe it's the smell, maybe the feeling of cold liquid on her back? I don't know what's the big deal, it's only a few drops. Anyway, this is the fourth dog I've had that has hated it.

Rated 1 out of 5 stars
By 239bodie on Jun 20, 2022

doesn't work

My poor dog has never had fleas prior to using frontline plus, I called the hotline and they said it takes 3 months to totally work. It's now been 4 months and I'm still finding random fleas on my dog. I'm changing to a different brand

Rated 5 out of 5 stars
By Dogs on Jun 18, 2022

Works Great!

I've used this product for years on and off. Pets showed signs of fleas for 1st time in long while and I was happy to see frontline was available! Found dead fleas w/in 24 hours & scratching stopped w/in 2 days.

Rated 5 out of 5 stars
By Nilla on Jun 19, 2022

Great flea and tick prevention

Seems to work really well, and the oily spot at the application spot went away after a day. My dog didn't even know what happened and it did not seem to cause her any discomfort.

Rated 5 out of 5 stars
By Alana on May 31, 2022

Absolute Gem

Works incredibly well. Noticed a tick on my dog two days after applying, and it was DEAD. Used this product for a considerable amount of time. Never going to switch as long as the formula stays the same!

Rated 5 out of 5 stars
By honey on Jun 15, 2022

Frontline plus

Great treatment for my Blue. All I have to say is .. It works, been using for a while. No side effects , no greasy build up on his fur.

Rated 5 out of 5 stars
By BaileytheBasset on Jun 26, 2022

Tick Free Summer

Travel every weekend to an area noted for ticks. Although other dogs that visit frequently have ticks Bailey has never had one