Frontline Plus Flea & Tick Treatment for Dogs (89-132 pounds)

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Frontline Plus doesn’t just kill adult fleas and ticks but also slays the next generation of flea eggs and larvae. Plus, it works non-stop for 30 days on dogs. Frontline Plus has 2 tough killing ingredients. The 1st, fipronil, kills adult fleas and ticks. The 2nd, (S)-methoprene, attacks flea eggs and larvae. They work together to kill all month long. Plus, it breaks the flea life cycle. By also destroying the next generation of flea eggs and larvae, Frontline Plus gives you the power to help prevent a flea infestation on your pet. Frontline products are highly recommended by veterinarians for flea and tick control for dogs.

Key Benefits

  • Provides fast-acting, long-lasting treatment and control and is safe for use on dogs and puppies 8 weeks or older
  • Kills adult fleas, ticks, chewing lice, mites, and flea eggs and larvae that may transmit Lyme disease
  • Highly recommended by veterinarians for flea and tick control for dogs
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for 30 days
  • Provides waterproof effectiveness so that it won't wash off from swimming or baths

Additional Details

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately. Observe your pet following treatment. Sensitivities may occur after using ANY pesticide product on pets. Please read entire manufacturer’s insert prior to using product. Approved for use in breeding, pregnant, or nursing animals. Consult with veterinarian before using on sick, medicated or aged animals.

Active Ingredients

  • Fipronil 9.8%
  • (S)-methoprene 8.8%

See all items by Frontline

  • Item Number
  • Brand
  • Breed Size
    Large Breeds, Giant Breeds
  • Lifestage
    Adult, All Stages


  • Snap open the tip of the Frontline applicator away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
  • Squeeze applicator to apply entire contents in a single spot on the skin monthly.
  • Allow 24 hours before bathing or swimming.

Additional Tips

  • Remove dog's collar
  • Apply as a spot between your dog's shoulder blades in 1 area that can't be licked.
  • Avoid touching the wet application spot.
  • Wait 24 hours to allow solution to dry before bathing or letting your dog swim.
  • Give each of your dogs its own complete dose.

Frequency of Application

  • When used monthly, FRONTLINE Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply FRONTLINE Plus for 30 days.
  • FRONTLINE Plus kills adult fleas, flea eggs, and flea larvae for up to three months. FRONTLINE Plus also prevents development of all flea stages for up to three months. FRONTLINE Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed.
  • FRONTLINE Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. FRONTLINE Plus kills all life stages of ticks (larva, nymph and adult).
  • FRONTLINE Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases.
  • FRONTLINE Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
  • FRONTLINE Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
  1. Frontline Plus Use & Care Instructions


Frequently Asked Questions

How does FRONTLINE Plus kill fleas and ticks?

FRONTLINE Plus has 2 secret weapons: fipronil and (S)-methoprene. Once FRONTLINE Plus is applied, this combo stores itself in the oil glands in your pet's skin. It then self-distributes continuously for 1 month to your pet's hair and skin through the hair follicles. Fleas or ticks that come in contact with your pet are dead meat.

How long does it take for FRONTLINE Plus to kill fleas?

In a study, FRONTLINE Plus began killing fleas 4 hours after application.1 Another study showed that within 12 hours, Frontline Plus killed 100% of fleas.2

Do fleas and ticks have to bite my pet for FRONTLINE Plus to work?

No. FRONTLINE Plus kills fleas and ticks through contact with your pet's haircoat. No biting necessary.

Why am I seeing more fleas on my pet after applying FRONTLINE Plus?

Fleas rise to the top of your pet's haircoat as they die. So if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

After using FRONTLINE Plus, I still see fleas in my home. Why?

The fleas you see most likely started as flea eggs that were deposited in the environment before you began using FRONTLINE Plus. Consecutive monthly applications of FRONTLINE Plus will assist with the elimination of an indoor flea life cycle. In some geographical regions in the United States, it may be required to use the product year-round.

Does FRONTLINE Plus have an expiration date?

No. As long as you keep it at room temperature and sealed in its original packaging, FRONTLINE Plus will remain ready for battle.

How long after application can my pet be bathed or go swimming?

FRONTLINE Plus remains effective for 30 days, even if your pet swims or is bathed. After application, keep your pet from getting wet for 24 hours. If FRONTLINE Plus is to be applied after a bath, make sure your pet is completely dry before application.

Can I use it if my pet is on medication?

Before using FRONTLINE Plus, ask your vet about possible interactions with any medications your dog is taking.

Can I use FRONTLINE Plus if I have already applied another flea and tick control product?

Before using, consult your veterinarian.

Does FRONTLINE Plus kill anything else besides fleas and ticks?

You bet. FRONTLINE Plus also kills chewing lice.

Can FRONTLINE Plus be used on pets other than dogs and cats?

No. FRONTLINE Plus should be used on dogs and cats only. There are specific products based on what kind of pet you have and how much it weighs. Be sure to use the right product for your pet.

Can I apply it more than once a month?

Don't reapply FRONTLINE Plus before the month is through. It keeps working for a full 30 days.

How old does my pet need to be in order to have FRONTLINE Plus applied?

At 8 weeks your pet can start benefiting from the power of FRONTLINE Plus.

Customer Reviews

224 reviews 224 Reviews 4.6 out of 5 Stars

94% Recommend

94% of reviewersrecommend this product

4.6 / 5

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  • Chewy.com order

    By on

    Oh my goodness I was impressed wirh the speed and accuracy of my order . This is a vary efficient company . They kept me in the loop my order was delivered before the promise date . I will order from Chewy .com again , I have been telling people how I am withe your company. Thank you Brenda

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  • Great price!

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    We have always used Frontline for our dogs. It keeps them completely free of fleas, without the worrisome side effects that other flea products have. We are so pleased to get this product at this amazing price!

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  • Doesn't work for us

    By on

    My dogs actually seem to have a worse flea problem since using this product. I've washed all of their beds & blankets and they got their frontline 2 weeks ago. :(

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  • Better Items and Prices

    By on

    I recently bought a 6-dose Frontline treatment for my 90+ German Shepherd and am so pleased with the service, ease, and price of the item. (Way less money than what it costs at my vet's office.) I also buy my "poop bags" from Chewy.Com as they have recently stocked a cheaper item in Petsmart, but the bags are so flimsy - well I don't have to tell you what happened! I will continue to buy all supplies for my Shepherd and my Scottish Terrier from Chewy.Com.

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  • Excellent- as expected

    By on

    I've been using this product for my rescues (cats & dogs) for years. I tried chewy.com for the first time. As you can see the price for this product is not cheap. I purchased this for my latest adoptee a gorgeous black GSD who weighs in at 120 and is not quite full grown! However, it is the same price or lower than many other online pet supply stores that I've used. On top of that, free shipping and I received my package the next day. Brilliant !

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  • Good product

    By on

    Very good prices,cheapest I found,I have been using this product for 15 years for my three different dogs.work very good.

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  • A Favorite Standby....

    By on

    I've used Frontline for years, "converted" to Bravecto (chewables) for the last 2 years, but with a dog that has such a sentitive digestive system (IBS, IBD) it just isn't worth the misery the chewables gives him. And with 5 dogs, it's a challenge keeping everybody on the same approach. The product will be the same, but the clincher for me (the difference in using other businesses)....the packages arrived in pristine condition.....WELL packaged, and because I added it to another item, in 2 days!

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  • Frontline Plus

    By on

    We have ALWAYS used Frontline Plus for our dogs over the years and have never had a problem with it. Our dogs don't have fleas and it hasn't had any side effects on our dogs like the newer flea remedies out on the market that cause sickness and disease in dogs. We LOVE Frontline Plus and so do our two dogs:) We give it a 5 wags in GOLD stars! Wolf!

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  • Excellent protection for us since 2007

    By on Top 250 Contributor

    I've used Frontline / Frontline Plus since 2007 on nine dogs with excellent results. All my pups and guardian dogs have arrived uninfested, and stayed that way with this product. We are in Minnesota, (which isn't as cold as it used to be) and have a very strong tick season. Not one tick in over ten years! No fleas, ever. Although I use as few chemicals as possible on my dogs, the protection and safety that Frontline provides is absolutely worth it, and Chewy's price is a terrific savings.

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  • Necessary product

    By on

    This product is necessary for flea and tick prevention. Excellent price f I really it. Thanks, Chewy!

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