Heartgard Plus Chew for Dogs, 26-50 lbs, (Green Box)

By Heartgard
Rated 4.902 out of 5 stars
Prescription Item

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$104.49Chewy Price
$116.79Chewy Price
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$12.30 (11%)
$99.27Autoship Price
(Save an extra 5%)

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  • Save 5% on all future Autoship orders
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Usually arrives in 3-5 days
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Medications ship separately. Delivery times may vary.

About This Item


For use in animals only. Heartgard Plus Chew for Dogs, 26-50 lbs. is a heartworm preventative that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older. Head back to the dog park, reassured that your dog is protected from nasty parasites with this heartworm preventative that's trusted over 2 billion times! Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Heartgard From Our Team of Experts
Learn More About Heartgard From Our Team of Experts

Frequently Bought Together

NexGard Chew for Dogs, 24.1-60 lbs, (Purple Box), 6 Chews (6-mos. supply)
Rated 4.483 out of 5 stars
$138.99Chewy Price
Total Price: $302.24

About HEARTGARD Plus for Dogs

#1 with Dog and Vets*

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Why Choose HEARTGARD Plus?

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Heartworm Prevention

The invisible threat of heartworm disease can be caused by one bite from an infected mosquito.

Veterinarian #1 Choice*

With over 2 billion doses prescribed, HEARTGARD Plus is the #1 choice of vets for their patients and their own dogs.*

#1 Dog-Preferred Chew*

The real-beef chew makes monthly dosing easy and enjoyable.*

Monthly Protection

When given every 30 days, HEARTGARD Plus can help keep your dog protected year-round.

Hookworms and Roundworms

Also treats and controls 3 species of hookworms and 2 species of roundworms.

Safe for Puppies

Safe for puppies as young as 6 weeks old with no minimum weight requirement.

For Dogs of All Sizes

Comes in three sizes: Up to 25 lbs., 26-50 lbs. and 51-100 lbs.

Heartworm Disease is an Invisible Threat

A Year-Round Risk for All Dogs

1 million dogs are estimated to be heartworm positive in the USA with cases reported in all 50 states.* The American Heartworm Society (AHS) recommends protecting dogs year-round and testing for heartworm disease every 12 months.*

1.  A mosquito ingests heartworm microfilariae after feeding on an infected animal.

2. Microfilariae become larvae and the mosquito can infect the next dog.

3. Larvae left on the skin develop in dogs.

4. Heartworm larvae migrate from the skin into the bloodstream of their new host, maturing as they go

5. Juvenile and adult heartworms primarily live in the pulmonary blood vessels of an infected dog.

6. Within 6 months of infection, adult heartworms are present in the pulmonary arteries.

7. When a mosquito bites an infected dog, the cycle can begin again.

Product Guide

HEARTGARD Plus is available in a variety of sizes by dog weight. Choose the option that best fits your dog.


Up to 25 lbs

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26 - 50 lbs

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51 - 100 lbs

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Just one bite from an infected mosquito could put your dog at risk for heartworm disease, but HEARTGARD Plus offers the protection your dog needs. This heartworm preventive is made with real beef and has a savory taste, making it the #1 dog-preferred chew. HEARTGARD Plus makes protecting your dog year-round easy and enjoyable month after month.*



  1. Data on file at Boehringer Ingelheim.
  2. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.
  3. Heartworm prevalent in South, expanding in other hot spots. American Veterinary Medical Association. https://www.avma.org/javma-news/2020-08-01/heartwormprevalent-south-expanding-other-hot-spots. Accessed December 23, 2021.
  4. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2020/all/heartworm-canine/dog/united-states. Accessed November 18, 2021.
  5. Heartworm Guidelines. American Heartworm Society. https://www.heartwormsociety.org/veterinary-resources/ american-heartworm-society-guidelines. Accessed December 23, 2021.

ReviewsWrite a Review

Rated 4.902 out of 5 stars
939 Ratings
Would recommend to a friend

850 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 4 out of 5 stars
By Sharon on Nov 5, 2023


The only reason I'm giving this 4 stars is because of the confusion when ordering a prescription item where the prescription is already on file. The system only offers 2 options: 1) I will mail the prescription; 2) Chewy will contact the vet. In this instance, the prescription was a refill for a script already on file as confirmed right on the web site. It would be more logical to offer a 3rd option for the customer: 3) Prescription already on file. The two options offered do not make sense for the circumstances in these cases.

Rated 5 out of 5 stars
By Suzanne on Nov 27, 2023

So Easy

Sent in an order for a prescription item for my dog for the first time. It was so easy to do and I had the item in less than a week (and now on an auto-fill for every 6 months). Plus it was the best price that I could find when I was researching the med. Would highly recommend doing your pet meds through Chewy.

Rated 5 out of 5 stars
By Patricia on Nov 14, 2023

Heartgard + Chew for Dogs

Hi everyone! I recently ordered the Heartgard Plus Chew (26-50 lb.) for for my dog Frankie Vegas. I found that when I ordered placed the prescription on a 1-time Auto-Ship, I saved between $4-$5 on the cost of the medication by ordering it from Chewy, rather than buying it directly from my veterinarian. . .plus Chewy ships free! Thank you Chewy!

Rated 5 out of 5 stars
By Jennifer on Nov 7, 2023


I started getting heartguard and nexguard for my pups pest control needs when my vet recommended these types of meds be taken separately a few years ago. I feel more comfortable giving them their flea n tick meds a week or two apart from their heartworm meds as to not overmedicate them. They also enjoy the flavors of these much better. And they took each without the need of pill pouches.

Rated 5 out of 5 stars
By Susan on Nov 15, 2023

Great product that I have used for many years and on multiple dogs.

The speed in which Chewy got a response from my vet, who is notorious for taking forever to get back to anyone, was amazing! I have loved Chewy since the first time I ordered from them. Thank you Chewy for your stellar customer service!

Rated 4 out of 5 stars
By sally on Nov 2, 2023

Great service but

There is no excuse for these products to be so ridiculously expensive- many dog owners can’t afford this and so unable to treat their pet then the dog gets sick , vet bills are outrageous and the dog goes to a “ rescue” or dropped off in the streets. Please make this affordable!!!

Rated 5 out of 5 stars
By Lauren on Nov 4, 2023


My boy, Murray, has no problem eating this like it's a delicious treat. This one passes the taste test! My vet here in northern michigan recommended heartgaurd and since Murr has already reacted well in the past to it we will stick to it!

Rated 5 out of 5 stars
By Cjet03 on Sep 30, 2023

This is an absolute most!

I have used this heart guard for many, many years over the span of the life of four dogs. It is an absolute must to prevent heart worm. Heartworm is a deadly disease. Treatment for the animal is ungodly. The prevention is so much less expensive and so easy. My dogs think it's a treat.

Rated 5 out of 5 stars
By Sharon on Nov 27, 2023

Peace of mind!

I give my two whippets a chewable Heartgard every month all year round. I have total peace of mind that they are covered and we don't have to worry at all.

Rated 5 out of 5 stars
By Jenna on Oct 1, 2023

Great Product

I rescued a dog from our local shelter that was heart worm positive. It was a horrible ordeal to get her to test negative nearly a year and I have used Heartguard Plus for her ever since and she has always tested negative. I live in the south where heartworm is very prevalent. Susie loves the taste