Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box)

By Heartgard
Rated 4.8833 out of 5 stars
Prescription Item

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About This Item


For use in animals only. Heartgard Plus Chew for Dogs, up to 25 lbs. is a heartworm preventative that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older. Head back to the dog park, reassured that your dog is protected from nasty parasites with this heartworm preventative that's trusted over 2 billion times! Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Heartgard From Our Team of Experts
Learn More About Heartgard From Our Team of Experts

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Rated 4.6618 out of 5 stars
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Total Price: $75.54

About HEARTGARD Plus for Dogs

#1 with Dog and Vets*

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Why Choose HEARTGARD Plus?

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Heartworm Prevention

The invisible threat of heartworm disease can be caused by one bite from an infected mosquito.

Veterinarian #1 Choice*

With over 2 billion doses prescribed, HEARTGARD Plus is the #1 choice of vets for their patients and their own dogs.*

#1 Dog-Preferred Chew*

The real-beef chew makes monthly dosing easy and enjoyable.*

Monthly Protection

When given every 30 days, HEARTGARD Plus can help keep your dog protected year-round.

Hookworms and Roundworms

Also treats and controls 3 species of hookworms and 2 species of roundworms.

Safe for Puppies

Safe for puppies as young as 6 weeks old with no minimum weight requirement.

For Dogs of All Sizes

Comes in three sizes: Up to 25 lbs., 26-50 lbs. and 51-100 lbs.

Heartworm Disease is an Invisible Threat

A Year-Round Risk for All Dogs

1 million dogs are estimated to be heartworm positive in the USA with cases reported in all 50 states.* The American Heartworm Society (AHS) recommends protecting dogs year-round and testing for heartworm disease every 12 months.*

1.  A mosquito ingests heartworm microfilariae after feeding on an infected animal.

2. Microfilariae become larvae and the mosquito can infect the next dog.

3. Larvae left on the skin develop in dogs.

4. Heartworm larvae migrate from the skin into the bloodstream of their new host, maturing as they go

5. Juvenile and adult heartworms primarily live in the pulmonary blood vessels of an infected dog.

6. Within 6 months of infection, adult heartworms are present in the pulmonary arteries.

7. When a mosquito bites an infected dog, the cycle can begin again.

Product Guide

HEARTGARD Plus is available in a variety of sizes by dog weight. Choose the option that best fits your dog.


Up to 25 lbs

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26 - 50 lbs

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51 - 100 lbs

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Just one bite from an infected mosquito could put your dog at risk for heartworm disease, but HEARTGARD Plus offers the protection your dog needs. This heartworm preventive is made with real beef and has a savory taste, making it the #1 dog-preferred chew. HEARTGARD Plus makes protecting your dog year-round easy and enjoyable month after month.*



  1. Data on file at Boehringer Ingelheim.
  2. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.
  3. Heartworm prevalent in South, expanding in other hot spots. American Veterinary Medical Association. https://www.avma.org/javma-news/2020-08-01/heartwormprevalent-south-expanding-other-hot-spots. Accessed December 23, 2021.
  4. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2020/all/heartworm-canine/dog/united-states. Accessed November 18, 2021.
  5. Heartworm Guidelines. American Heartworm Society. https://www.heartwormsociety.org/veterinary-resources/ american-heartworm-society-guidelines. Accessed December 23, 2021.

ReviewsWrite a Review

Rated 4.8833 out of 5 stars
1636 Ratings
Would recommend to a friend

1488 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Ashley on Nov 3, 2023

Thanks, Chewy!

I needed Heartgard for my dogs and my vet dithered about approving the Rx delaying the order. Chewy stayed in communication with me and tried their best to get the order moving. The vet finally managed to get their records right (after I had a minor meltdown) and approved the order. The NEXT DAY my Heartgard arrived. My newly adopted dog was treated for heart worm 6 months ago and has advanced heart disease and needs to get his preventative on time. Thanks to Chewy’s efficient, professional pharmacy staff he was only a day late. love Chewy! PS: I’m sticking with Chewy and getting a new vet.

Rated 1 out of 5 stars
By Karen on Nov 20, 2023

Didn't Recieve

We left October 30th for Yuma, AZ. Usually we get our order in 3 days, it was 5 days and we left for our winter home. It may still be on our porch, however our son checks once a week and never said anything. It would have been stored too cold if outside now. I figured the vet didn't OK it and didn't see the sent message on October 30th. Guess I'm out over $100, not really your fault though.

Rated 5 out of 5 stars
By Thomasina on Nov 22, 2023


We live in Florida where heartworms can be passed around frequently. The treatment for heartworms is very, very debilitating to dogs. Dogs are lucky to survive the treatment itself. Heartgard is a time-proven preventative. We've been using it for many years. Easy to use. Dogs think it's a treat.

Rated 5 out of 5 stars
By Mary on Dec 6, 2023


He ate this up like it was a treat. I will be buying this every single month for my Maltese child. Tried a more expensive one from my vet and he hated it!!! THIS IS IT, ITS THE MOMENT, ITS THE GOOD GOOD!!!

Rated 5 out of 5 stars
By Aimee on Nov 20, 2023

Love the ability to purchase one pill at a time

My dog eats these Heartgard chews with no problems. I appreciate being able to purchase one chew at a time. Since the tick season here is shorter I often need only 7 chews in a year, not 12 (two 6-pack boxes).

Rated 5 out of 5 stars
By Mary on Nov 13, 2023

My girls look love their once a month Heartgard Plus!

I've been giving my dogs HeartGard Plus for over 35 years. They love the real-beef flavor & I love knowing they are being protected against heartworms, hookworms & roundworms. I will continue to use this product as long as it's available & I own dogs.

Rated 5 out of 5 stars
By NJR on Nov 11, 2023


Chewy always does a great job with everything that they ship - it doesn’t matter if it’s an auto-ship of food, it’s toys, or if it’s medication from the pharmacy !!! You can always trust your fur babies to Chewy !!!

Rated 3 out of 5 stars
By Roger on Nov 14, 2023


When I ordered my pet medicine, Chewy offered a discount. When they finally got the Ok from the Vets and shipped the meds, they they resided the offer saying it expired. It was expired when I ordered the medication

Rated 5 out of 5 stars
By Sandy on Nov 10, 2023

Snuggles has her medicine

Chewy made ordering Snuggles medicine so easy, working with Snuggles veterinarian I made an error and Stephanie at Chewy so graciously corrected it, right away Outstanding service! Snuggles sends kisses Sandy

Rated 5 out of 5 stars
By Paul on Oct 16, 2023

Good service

We use this product for 10 plus years. Tried the Chewy pharmacy as our current vet does not carry this product. Pharmacy took 4 days to approve then another 2 business days of shipping. Not bad as long as it is not medication you need asap. Saved 1.75 hr trip to another vet to fill it.