Heartgard Plus Chew for Dogs, up to 25 lbs, (Blue Box)

By Heartgard
Rated 4.8937 out of 5 stars
Prescription Item

Pet Weight:

Selected: Pet Weight:

Pet Weight:

Selected: Pet Weight:


Selected: Count:


Selected: Count:

$48.59Chewy Price
$55.99Chewy Price
You save:
$7.40 (13%)
$46.16Autoship Price
(Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
  • Set your schedule based on your pet's needs
  • No fees, no commitments - skip, change or cancel anytime.

In Stock
FREE delivery
Usually arrives in 3-5 days
We'll collect your pet's prescription information at Checkout.
This item requires prescription approval.

Medications ship separately. Delivery times may vary.

Frequently Bought Together

NexGard Chew for Dogs, 10.1-24 lbs, (Blue Box), 6 Chews (6-mos. supply)
Rated 4.6521 out of 5 stars
$136.49Chewy Price
Total Price: $249.99

About This Item


For use in animals only. Heartgard Plus Chew for Dogs, up to 25 lbs. is a heartworm preventative that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older. Head back to the dog park, reassured that your dog is protected from nasty parasites with this heartworm preventative that's trusted over 2 billion times! Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

See More




Play Video: Learn More About Heartgard From Our Team of Experts
Learn More About Heartgard From Our Team of Experts

About HEARTGARD Plus for Dogs

#1 with Dog and Vets*

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Why Choose HEARTGARD Plus?

When it comes to preventing the invisible threat of heartworm disease, pet parents and veterinarians can agree that HEARTGARD Plus (ivermectin/pyrantel) is the #1 choice.* Not only does it prevent heartworm disease, but it also treats and controls 3 species of hookworms and 2 species of roundworms all with the real-beef taste dogs love.*

Heartworm Prevention

The invisible threat of heartworm disease can be caused by one bite from an infected mosquito.

Veterinarian #1 Choice*

With over 2 billion doses prescribed, HEARTGARD Plus is the #1 choice of vets for their patients and their own dogs.*

#1 Dog-Preferred Chew*

The real-beef chew makes monthly dosing easy and enjoyable.*

Monthly Protection

When given every 30 days, HEARTGARD Plus can help keep your dog protected year-round.

Hookworms and Roundworms

Also treats and controls 3 species of hookworms and 2 species of roundworms.

Safe for Puppies

Safe for puppies as young as 6 weeks old with no minimum weight requirement.

For Dogs of All Sizes

Comes in three sizes: Up to 25 lbs., 26-50 lbs. and 51-100 lbs.

Heartworm Disease is an Invisible Threat

A Year-Round Risk for All Dogs

1 million dogs are estimated to be heartworm positive in the USA with cases reported in all 50 states.* The American Heartworm Society (AHS) recommends protecting dogs year-round and testing for heartworm disease every 12 months.*

1.  A mosquito ingests heartworm microfilariae after feeding on an infected animal.

2. Microfilariae become larvae and the mosquito can infect the next dog.

3. Larvae left on the skin develop in dogs.

4. Heartworm larvae migrate from the skin into the bloodstream of their new host, maturing as they go

5. Juvenile and adult heartworms primarily live in the pulmonary blood vessels of an infected dog.

6. Within 6 months of infection, adult heartworms are present in the pulmonary arteries.

7. When a mosquito bites an infected dog, the cycle can begin again.

Product Guide

HEARTGARD Plus is available in a variety of sizes by dog weight. Choose the option that best fits your dog.


Up to 25 lbs

Shop Now


26 - 50 lbs

Shop Now


51 - 100 lbs

Shop Now


Just one bite from an infected mosquito could put your dog at risk for heartworm disease, but HEARTGARD Plus offers the protection your dog needs. This heartworm preventive is made with real beef and has a savory taste, making it the #1 dog-preferred chew. HEARTGARD Plus makes protecting your dog year-round easy and enjoyable month after month.*



  1. Data on file at Boehringer Ingelheim.
  2. HEARTGARD® Plus (ivermectin/pyrantel) Chewables [Freedom of Information Summary; NADA 140-971]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.
  3. Heartworm prevalent in South, expanding in other hot spots. American Veterinary Medical Association. https://www.avma.org/javma-news/2020-08-01/heartwormprevalent-south-expanding-other-hot-spots. Accessed December 23, 2021.
  4. Heartworm Parasite Prevalence Maps. Companion Animal Parasite Council. https://capcvet.org/maps/#/2020/all/heartworm-canine/dog/united-states. Accessed November 18, 2021.
  5. Heartworm Guidelines. American Heartworm Society. https://www.heartwormsociety.org/veterinary-resources/ american-heartworm-society-guidelines. Accessed December 23, 2021.

ReviewsWrite a Review

Rated 4.8937 out of 5 stars
1383 Ratings
Would recommend to a friend

1363 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Ginny on Sep 6, 2023

Why this is a great product.

I have been using this particular product for my dogs since 1995. I used it for my first dog, squeaker. In all of his 18 1/2 years that he lived, he never had problems with Heartworms while he took this product once a month. Now, I give it to my two dogs every month on the first. They have never had problems with Heartworms, and I highly recommend this product if you do not want any trouble with heart worms. It is Totally tried and true.

Rated 5 out of 5 stars
By Samanjesse3 on Sep 5, 2023

Best heartworm treatment for my dogs

I will never switch again. My vet doesn’t sell this and convinced me to use Interceptor +. It’s supposed to be chewable but it’s hard as a rock, and my small dogs hated it. After many unsuccessful attempts to hide it in food, even pulverizing into granules, I threw up my hands. Heartgard is actually soft and they love it! Problem solved!

Rated 5 out of 5 stars
By Melody on Aug 27, 2023

Used it for several years now!

I have 2 little dogs and they have been on Heartgard for several years now. I have them tested every year because we are in bad area for heart worm infection. As long as they are taking it regularly if they should contract heartworms my vet says the Heartgard company covers he cost of their treatment.

Rated 3 out of 5 stars
By Pen21au on Jul 25, 2023

Not totally satisfied

I buy these expensive pills faithfully for my 2 fur babies. Very expensive for me seeing am on fixed income. Every once in a while one pill is hard as a rock and I lose money. Be careful of these pills for that reason. I lost money on the last package for 2 were very hard cannot be given to one of my fur babies.

Rated 5 out of 5 stars
By Sheila on Aug 16, 2023

Trusted Product

This is what our Veterinary recommends. We've been using this for many years. Now they are soft chews which is great since our little dog has very few teeth left. Makes it easier for her to chew.

Rated 5 out of 5 stars
By Janet on Sep 15, 2023

Convenient ordering

Never knew it was so easy to get our dogs’ meds without any delay or red tape like the company I had been dealing with for YEARS!

Rated 5 out of 5 stars
By Lyle on Jul 18, 2023

Dog loves it

My dog had been first given a hard tablet that he would lick and spit out and I would have to crush it into his food to eat it. With Heartgard, I have not had that problem. He looks forward to it when I take it out the box each month. He thinks it’s a treat.

Rated 5 out of 5 stars
By Donna on Aug 2, 2023

Heartgard Plus Chew for dogs up to 25lbs.

First time buying this product for a newly acquired rescue dog, who has been on it previously, so we decided to keep him on it. Our Doberman has been on it her whole life, so we feel it is a good product.

Rated 5 out of 5 stars
By Sandy on Aug 2, 2023

Chewy is the best!

Chewy has the best customer service,always willing to help you with anything you need. Customer service is above any other I had dealt with. We will continue to buy from Chewy for our little Happy!

Rated 2 out of 5 stars
By sensitivedog on Jun 25, 2023


My dog likes the taste, but I’ve given it to him three times and each time it has caused him to have diarrhea for a couple of days. He does have a very sensitive stomach. I talked to his vet and I decided to continue giving it to him, just knowing he’ll have diarrhea a few days a month, and try something else after this pack is gone.