KBroVet-CA1 Chewable Tablets for Dogs, slide 1 of 1

KBroVet-CA1 Chewable Tablets for Dogs

Prescription Item

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Strength: 500-mg
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Count: 60 tablets

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Description

KBroVet-CA1 is a prescription chicken-liver-flavored chewable tablet containing potassium bromide to treat seizure disorders. In addition to therapy, it can be used in combination with other anti-seizure medications or as the sole anticonvulsant. KBroVet-CA1 differs from KBroVet in two ways: 1) KBroVet-CA1 does not contain the inactive ingredient cyanocobalamin (vitamin B12) and 2) tablets are no longer scored. Patients may transition directly to the new formulation, with no need for any dosing adjustments.

Uses

KBroVet-CA1 (potassium bromide chewable tablets) are indicated for the control of seizures associated with idiopathic epilepsy in dogs.

Possible Side Effects

In a retrospective field study of 51 dogs diagnosed with idiopathic epilepsy and receiving only KBr to control seizures associated with idiopathic epilepsy, adverse reactions were documented for the initial 60 days of treatment. Increased appetite, weight gain, vomiting/regurgitation and sedation were the most common clinical abnormalities documented in the 60 day period after start of KBr therapy. Adverse reactions were also documented during the 30 days prior to KBr sample submission. Weight gain, weakness, ataxia, and increased appetite were the most common adverse reactions documented during this time period. Adverse events associated with concurrent use of KBr with other antiepileptic drugs such as phenobarbital have been reported. Neurologic signs were the most common adverse event and included sedation, irritability, restlessness, depression, behavioral changes, ataxia, hind limb paresis, mydriasis, stupor, and coma. The neurologic signs were reported to be reversible.

Drug & Food Interactions

KBroVet-CA1 should not be used in animals with a history of hypersensitivity to bromide.

Precautions

Dogs receiving KBr should be carefully monitored when changing diets, administering chloride-containing IV fluids, and administering concurrent medications. Careful monitoring is important in dogs that have a condition that may cause difficulty maintaining electrolyte balance. Animals with decreased renal function may be predisposed to bromide toxicosis. Some dogs may experience epileptic episodes that are unresponsive or refractory to KBr monotherapy and KBr alone may not be adequate treatment for every dog with idiopathic epilepsy. The safe use of KBroVet-CA1 has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating. The safe use of KBr in neonates and young animals has not been established. Reproductive effects of KBr have been reported in other species. In dogs, ataxia, diarrhea, hematochezia, excessive salivation, shivering, skin lesions, stupor progressing to coma and death have been reported with a dose of 200 to 500 mg/kg a day for 4 to 26 weeks.

Also available in an oral solution.

  1. Prescribing Information

See all items by KBroVet-CA1

  • Item Number
    146864
  • Common Brand Name(s)
    K-BroVet-CA1, PRN
  • Generic Name
    Potassium Bromide
  • For Use With
    Dogs
  • Administration Form
    Oral
  • Product Form
    Chewable Tablet
  • Health Condition
    Seizures
  • Drug Type
    Anticonvulsant
Ingredients
Ingredients

Potassium Bromide.

Instructions
Recommended Dosage

The total recommended daily dosage range for oral administration is 25–68 mg/kg (11–31 mg/lb) of body weight. The dosage of KBroVet-CA1 should be adjusted based on monitoring of clinical response of the individual patient. KBroVet-CA1 may be dosed with or without food. Use of an initial loading dosage regimen may be considered on an individual patient basis, balancing the time required to achieve a therapeutic response while minimizing side effects.

Storage Instructions

Store at controlled room temperature 20–25°C (68–77°F).

FAQ

What are the differences between KBroVet-CA1 (potassium bromide chewable tablets) and the former KBroVet tablets?

The two products are labeled differently due the FDA’s conditional approval of KBroVet-CA1. Please see the full product label and package insert for details. Additionally, the tablets are no longer scored, nor contain cyanocobalamin (vitamin B-12). All other ingredients remain the same.

What does conditionally approved mean?

KBroVet-CA1 is conditionally approved by the FDA. This means that the product has been proven safe and has a reasonable expectation of effectiveness. The sponsor will continue to collect the evidence of effectiveness needed for the product to receive full approval. Conditionally approved animal drugs are limited to a specific use, which can be found on the package insert. Additional information on conditional approval can be found by searching http://fda.gov for “conditional approval.”

How does conditional approval differ from traditional/formal approval?

The FDA, following successful demonstration of efficacy, safety and manufacturing protocols, grants drug approvals. A conditional approval is granted for only certain types of treatments for serious or life-threatening conditions where demonstrating effectiveness requires complex or difficult studies. Once safety and manufacturing protocols have been proven, the FDA will consider an approval when there is a reasonable expectation of effectiveness for use. The conditional approval is for one year, must be renewed annually after showing progress toward full approval for up to four additional years.

As a veterinarian, can I transition a patient from the previous bottle of KBroVet tablets directly to the new KBroVet-CA1 tablets without a washout or transition period?

Yes.

I’ve been using KBroVet for years and I thought it was already approved. Was it not? Is this a step backward for the product?

By way of a close partnership with the FDA due to a recognized marketplace need, PRN Pharmacal has manufactured KBroVet for nearly a decade as an unapproved drug, while working toward completion of a formal approval. At this juncture, the FDA granted conditional approval based on reasonable expectation of efficacy, demonstrated safety and approval of manufacturing controls. This is a step forward for the product in the eyes of the FDA.

What size is a KBroVet-CA1 tablet?

It is approximately the size of a dime.

Can you feed KBroVet-CA1 with peanut butter?

There have been no tests dosing dogs with Bromides and feeding peanut butter or any other food combinations, as there are too many variables. The key is to monitor the serum bromide levels to keep them in the 1-3 mg/mL range. The dosing and diet need to be balanced to achieve this range.

What is the flavoring?

Tablets are artificial chicken liver and drops are artificial butterscotch. There is no sucrose in the drops.

Should the oral solution be refrigerated after opening?

No. The product should be kept at room temperature.

Rating: 4.7 of 5 stars 7 Reviews 7 Reviews 4.7 out of 5 Stars

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Rating: 4.7 of 5 stars 4.7 / 5

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7 Reviews

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  • 5 out of 5 stars

    Saved my boy!

    By Avalanche on Apr 21, 2021

    This combined with Keppra has been a lifesaver. He was having 3 seizures in one day every 30 days, but this has helped stop that and give him a normal life again.

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  • 4 out of 5 stars

    Not scored

    By Danny on Jun 15, 2021

    This shipment og K-brovet wasn't scored. It is a royal pain, even with a pill splitter

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  • 5 out of 5 stars

    Seizures in dogs

    By Thompson328 on Jul 25, 2020

    Very effective in controlling my dog's seizures. She takes 250 mg 2x daily along with Phenobarbital. She was having several cluster seizures once or twice per week and they stopped once she began taking 2 Potassium Bromide tablets per day. She was still having seizures when only taking one tablet daily so it is important to determine the correct dosage.

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  • 5 out of 5 stars

    5 seizures to seizure free!!!!!!

    By Melanie on Aug 2, 2020

    My shepherd, Lady had 5 seizures in 24 hr period. 2nd hospital prescribed her this. We have been to seizure free with this medicine !!!!

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  • 5 out of 5 stars

    Great Addition

    By Jenny on May 2, 2020

    Added this life saver with Pheno and Keppra, our boy has been seizure free since July 2019. It was a weekly occurrence, and the seizures were getting worse. So pleased with the results of this medicine!

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  • 5 out of 5 stars

    Good add on

    By Breanna on Sep 17, 2019

    We added this medicine with pheno. And my boy has gone the longest he's ever went between seizures. November will be 1 year!

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  • 4 out of 5 stars

    much better epilepsy control

    By Kmull on Oct 22, 2018

    My poodle cross is elderly and he does better on this medication. However if he gets any extra salt it, does conflict. but he is doing so much better on this medication. And his liver damage test results have improved, now that he is off the other meds.

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